Introduction to the Analysis of Bioactive Compounds in Marine Samples

Rocha-Santos, Teresa; Duarte, Armando C.

doi:10.1016/b978-0-444-63359-0.00001-x

Cited by 12 publications

(10 citation statements)

References 52 publications

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“…There are various classifications of alkaloids in terms of their chemical structure, biological activity, biosynthetic pathway, and composition as heterocyclic or nonheterocyclic compounds [ 51 ]. Kumar et al [ 52 ] classified alkaloids into seven subclasses: pyridoacrine alkaloids, indole alkaloid, pyrrole alkaloids, isoquinoline alkaloids, guadinine alkaloids, aminoimidazole alkaloids, and sterol alkaloids [ 53 ]. Alkaloids have been isolated from marine organisms such as sponges, tunicates, anemones, and mollusks, all of which are characterized bright colors and patterns, which are often related to alkaloids [ 54 ].…”

Section: Chemical Classification Of Marine Bioactive Compoundsmentioning

confidence: 99%

“…Compounds in this class include macrolides, polyethers, polyols and aromatic compounds. This class is often highly oxygenated [ 53 ] and contains multiple β-hydroxyketone or β-hydroxyaldehyde functional groups. Polyketides are complex organic compounds similar to fatty acids: first, because both are synthesized by the decarboxylative condensation of malonyl-CoA and other acyl-CoAs; however, in polyketides, more than one monomer type may be used to construct different sized aromatic groups or reduced chains.…”

Section: Chemical Classification Of Marine Bioactive Compoundsmentioning

confidence: 99%

“…These metabolites are isolated from sponges, ascidians, soft corals and bryozoans [ 33 ] and can be produced by commensal or symbiotic bacteria [ 61 ]. Polyketides possess wide-ranging biological activities, including antibiotic, anticancer, antifungal, antiparasitic and neurotoxic effects [ 53 ].…”

Section: Chemical Classification Of Marine Bioactive Compoundsmentioning

confidence: 99%

“…Terpenes are the final products from biosyntheses involving a five-carbon isoprene structure. Depending on the number of units, they can be classified as monoterpenes, sesquiterpenes, diterpenes, sesterterpenes, triterpenes (steroids), and tetraterpenes (carotenoids) [ 53 , 62 ]. Several groups of marine organisms produce terpenes, which exhibit biological activities such as cytotoxic, antiproliferative, antifouling, antifungal, and antimicrobial activities [ 63 ].…”

Section: Chemical Classification Of Marine Bioactive Compoundsmentioning

confidence: 99%

“…The major class of carbohydrates that can be isolated from marine organisms are polysaccharides [ 53 ], but it is also possible to obtain low molecular weight glycosylated oligosaccharides, usually from sponges and tunicates [ 68 ]. Polysaccharides are a diverse class of macromolecules comprising polymers of monosaccharides bonded with glycosidic residues and exhibiting a wide structural diversity [ 69 ].…”

Section: Chemical Classification Of Marine Bioactive Compoundsmentioning

confidence: 99%

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An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs

et al. 2017

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Marine secondary metabolites are a promising source of unexploited drugs that have a wide structural diversity and have shown a variety of biological activities. These compounds are produced in response to the harsh and competitive conditions that occur in the marine environment. Invertebrates are considered to be among the groups with the richest biodiversity. To date, a significant number of marine natural products (MNPs) have been established as antineoplastic drugs. This review gives an overview of MNPs, both in research or clinical stages, from diverse organisms that were reported as being active or potentially active in cancer treatment in the past seventeen years (from January 2000 until April 2017) and describes their putative mechanisms of action. The structural diversity of MNPs is also highlighted and compared with the small-molecule anticancer drugs in clinical use. In addition, this review examines the use of virtual screening for MNP-based drug discovery and reveals that classical approaches for the selection of drug candidates based on ADMET (absorption, distribution, metabolism, excretion, and toxicity) filtering may miss potential anticancer lead compounds. Finally, we introduce a novel and publically accessible chemical library of MNPs for virtual screening purposes.

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Section: Chemical Classification Of Marine Bioactive Compoundsmentioning

confidence: 99%

Section: Chemical Classification Of Marine Bioactive Compoundsmentioning

confidence: 99%

Section: Chemical Classification Of Marine Bioactive Compoundsmentioning

confidence: 99%

Section: Chemical Classification Of Marine Bioactive Compoundsmentioning

confidence: 99%

Section: Chemical Classification Of Marine Bioactive Compoundsmentioning

confidence: 99%

See 3 more Smart Citations

An Updated Review on Marine Anticancer Compounds: The Use of Virtual Screening for the Discovery of Small-Molecule Cancer Drugs

et al. 2017

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Oxygenated heterocyclic metabolites with dual cyclooxygenase-2 and 5-lipoxygenase inhibitory potentials from Rhizophora annamalayana

Chakraborty

Raola

2018

Med Chem Res

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Previously undescribed oxygenated heterocyclic metabolites were purified from the ethyl acetate fraction of natural mangrove hybrid Rhizophora annamalayana. The purified metabolites were characterized as 11-(tetrahydro-14α-hydroxy-13β-methylfuran-12-yl)-10β-methylbutyl benzoate (1), 13-(tetrahydro-15β,16α-dimethyl-18-oxo-2H-pyran-14-yl)-10β-methylhept-12(E)-enyl benzoate (2), and dihydro-11-((7E)-2-hydroxy-8β-methyl-2H-chromen-9-yl)-13-methylpent-12(E)-enyl)-17β-methylfuran-19(3H)-one (3) by the combined spectroscopic experiments. These metabolites were assessed for their antioxidant and anti-inflammatory activities, and compared with the commercially available standards. The purified compound 3 exhibited greater antioxidant activities as deduced by 2, 2'-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid and 2, 2-diphenyl-1-picrylhydrazyl quenching properties (IC 50 2.10 and 2.22 mM, respectively) compared to the positive control (α-tocopherol, IC 50 1.46 and 1.69 mM, respectively). Consequently, the anti-inflammatory activity of compound 3 with regard to the inhibitory property towards pro-inflammatory 5-lipoxygenase was greater (IC 50 2.16 mM) than that exhibited by the synthetic anti-inflammatory drug ibuprofen (IC 50 4.51 mM). Electronic and hydrophobic parameters were deduced to find the target bioactivities of the studied compounds. These oxygenated heterocyclic metabolites could be used as potential therapeutic lead compounds in the pharmaceutical applications.

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