Memorable events of the 21st century that will be rightly or wrongly be remembered includes the global financial crisis of 2007/08, the election of Mr Donald Trump as President of the United States of America, and Brexit (the United Kingdom (UK) voting to leave the European Union) in 2016. Others include the emergence of the Coronavirus (COVID-19) pandemic, and the war between Russia and Ukraine. Since 2016, Brexit has continued to dominate global politics. Conceptually, this article explores the Brexit dilemma, the formalization of Brexit agreements, and the post-Brexit impact on the economy and society. How did Brexit happen? What are the underlying causes of Brexit? Is Brexit connected to Euroscepticism and populism? By evaluating these contexts, important issues and debates can be reconciled to advance knowledge on Brexit, UK politics, the regional political system, and the rise of populism. This article is currently relevant since it coincides with an obvious upsurge in interest in the post-Brexit Global Britain.