Introduction to the Special Issue “Skeletal Muscle Atrophy: Mechanisms at a Cellular Level”

Zuccaro, Emanuela; Marchioretti, Caterina; Pirazzini, Marco; Pennuto, Maria

doi:10.3390/cells12030502

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Weight loss occurs because the body experiences a loss of muscle mass (Schneider, 2022). Skeletal muscle is one of the most abundant tissues in the body and requires a lot of energy during activities (Zuccaro et al, 2023). The nutritional status of toddlers with PED was assessed by anthropometric, biochemical, physical-clinical, and food consumption methods.…”

Section: Introductionmentioning

confidence: 99%

The Comparative Effect Between Pellets and Porridge Made from Local Ingredients on Body Weight of Rats with Protein-Energy Deficiency

Sanjaya,

Indarto,

Nurwati

2023

PICNHS

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Protein-energy deficiency (PED) is a major infant health problem in developing countries with high mortality rate. Inadequate food intake and infectious diseases are the main factors for PED. In clinical setting, branded foods are commonly used to treat the PED but these foods are expensive. Canna (Canna edulis Ker.), catfish (Pangasius sp.), and red beans (Phaseolus vulgaris) are easily found in Indonesia and rich carbohydrates and protein. Therefore, this study aimed to compare the effect between pellets and porridge from canna, catfish, and red beans (GANIME) on the body weight (BW) of rats with PED.Ten male wistar rats, which aged 3 weeks and weighed 50-100 g, were used in this in vivo study. The rats model with PED was made by using the existing method through 40-60% gradual feed restriction for 14 days. Selected rats were randomly divided into 2 groups: G1 was given GANIME pellets and G2 was given GANIME porridge for 14 days. The rat BW each group routinely weighed every 7 days.The average BW of G1 rats was 78,00 ± 15,52 g, which was not significant different from the average BW of G2 rats was 70,50 ± 2,12 g (p= 0,64). In group G1 there was a greater increase than in group G2, namely 12.67 grams.Administration of GANIME pellets increases more body weight in rats with PED, compared to administration of GANIME porridge.

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Section: Introductionmentioning

confidence: 99%

The Comparative Effect Between Pellets and Porridge Made from Local Ingredients on Body Weight of Rats with Protein-Energy Deficiency

Sanjaya,

Indarto,

Nurwati

2023

PICNHS

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C60 fullerene helps restore muscle soleus contraction dynamics after achillotomy-induced atrophy

Nozdrenko,

Bogutska,

Pampuha

et al. 2024

Biol. Stud.

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Background. The search for new means that would effectively influence the pathological consequences of muscle immobilization is an urgent priority request of modern biomedicine. Previously, the positive effect of water-soluble C60 fullerenes, as strong antioxidants, was established on the background of muscle ischemia, mechanical muscle injury, and other muscle dysfunctions. These carbon nanoparticles have been shown to reliably protect muscle tissue from damage caused by oxidative stress. Materials and Methods. The biomechanical parameters of muscle soleus contraction of rats were studied by simulating non-functioning hind limbs using a clinical model – a rupture of the Achilles tendon (achillotomy). Muscle contraction parameters, namely the maximum contraction force and muscle force impulse, were determined on the 15th, 30th, and 45th days after initiation of atrophy using tensometry. As a therapeutic nanoagent, daily oral administration of C60 fullerene aqueous solution at a dose of 1 mg/kg was used throughout the experiment. Results. Previous registration of muscle soleus contraction force when applying 1 Hz stimulation lasting 1800 s with three pools revealed a decrease in maximal force responses after 15, 30, and 45 days of atrophy. The 45th day after atrophy is considered to be the limit for the fastest recovery of the muscle after immobilization, the further process takes place over several months. In all the tests performed, the therapeutic administration of water-soluble C60 fullerenes (dose 1 mg/kg) an increase in biomechanical parameters was recorded (maximum force of contraction – the change in the form of the “stimulation – force contraction” dependence is a consequence of the development of the pathological process in muscle and the muscle force impulse, which allows assessing the performance of the muscular system after a long-term immobilization), by approximately 29–49±2 % for the maximum contraction force and by 21–37±2 % for the muscle force impulse compared to the atrophy group for 15, 30 and 45 days. Conclusions. The obtained results indicate the prospects of using water-soluble C60 fullerenes, which can alleviate pathological conditions in the muscular system that arise from skeletal muscle atrophy due to immobilization.

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Introduction to the Special Issue “Skeletal Muscle Atrophy: Mechanisms at a Cellular Level”

Cited by 2 publications

References 31 publications

The Comparative Effect Between Pellets and Porridge Made from Local Ingredients on Body Weight of Rats with Protein-Energy Deficiency

The Comparative Effect Between Pellets and Porridge Made from Local Ingredients on Body Weight of Rats with Protein-Energy Deficiency

C60 fullerene helps restore muscle soleus contraction dynamics after achillotomy-induced atrophy

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