Mental health care providers have been charged with the task of generating more evidence to support the quality and efficiency of their treatment practices. Health care policies are beginning to enforce the implementation of prescriptive treatment protocols with demonstrated efficacy for specific conditions. Psychotherapy treatment models designed for and evaluated in rigorously controlled experimental settings are frequently considered the hallmark of evidence-based practice. Experimental trials of psychotherapy brands have identified efficacious treatments for a number of specific conditions. However, the current experimental procedures for evaluating a specific treatment model may not be enough to account for the range of patients and challenges found in community practice settings. Clinicians express reservations that many research investigations do not address their most important concerns. Thus, clinical researchers are charged with the task of implementing research protocols of greater clinical utility. Public health practice settings offer numerous opportunities for joining clinical research and practice. However, implementing programmatic psychotherapy research in clinical practice settings presents a number of obstacles. In this article, a case example of implementing a research protocol in a public health safety-net hospital is the lens through which these obstacles are identified and possible solutions investigated. Experience gaps, financial constraints, design flaws, organizational culture, and clinician resistance are barriers to the implementation of practice-based psychotherapy research. With motivated efforts and creative problem solving, these barriers can be removed, opening an avenue for the advancement of practice-informed research and researchinformed practice.