Introductory Chapter: Autoimmune Epithelitis - Discussion about Sjögren’s Syndrome and Primary Biliary Cholangitis

Maślińska, Maria

doi:10.5772/intechopen.86258

Cited by 2 publications

(4 citation statements)

References 35 publications

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“…SS starts with the epithelial inflammation termed as autoimmune epithelitis and impaired function of the exocrine glands manifesting in the reduction of saliva or tear secretion. The secretory function is impaired through the reduction of secretion of the aqueous phase and changes in density of the secretion [11]. The lack of symptoms of dryness confirmed by objective tests in patients with MD is the main differentiative factor between SS and MD.…”

Section: Xerostomia and Xerophthalmia In Differentiative Diagnosis Ofmentioning

confidence: 99%

“…Glucocorticosteroids are combined with other immunosuppressive drugs. Steroids are implemented in the case of intensification of organ changes, vasculitis, and nervous sys-tem involvement [11]. Serologic and histopathological examinations play a crucial role in the diagnosis.…”

Section: Epidemiological Pattern and Clinical Presentationmentioning

confidence: 99%

“…The main consequences of ocular dryness include conjunctival hyperaemia and corneal epithelial damage leading to functional vision Diagnosis ≥ 4 points A total score of 4 for the above items meeting the criteria for primary SS impairment. Squamous metaplasia of the ocular surface epithelium, follicular conjunctivitis, corneal epitheliopathy, recurrent erosion, and corneal ulceration were also described in SS [11]. The rate of dry mouth in SS ranged from 41% at initial diagnosis to 84% 10 years after diagnosis [12].…”

Section: Xerostomia and Xerophthalmia In Differentiative Diagnosis Ofmentioning

confidence: 99%

“…Main epidemiological, clinical, serologic, and histopathological differences between MD and SS International Collaborative Clinical Alliance (SICCA), positive rheumatoid factor (RF) and ANA ≥ 1 : 320 are an equivalent to anti-SSA/SSB positivity, but they are not approved criteria by EULAR[11] …”

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confidence: 99%

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Mikulicz’s disease and Sjögren’s syndrome as the main autoimmune disorders involving salivary glands

Kamiński¹

2020

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Mikulicz's disease and Sjögren's syndrome involve salivary glands. They are characterised by lymphocytic infiltrations in affected exocrine glands leading to their swelling and dysfunction. Although they present similar clinical symptoms, currently they belong to different classifications and require different multidisciplinary treatments. This study presents and compares Sjögren's syndrome and Mikulicz's disease and reviews their main clinical, histopathological, and serologic criteria and the methods used in the diagnostic process. The most reliable diagnostic method is histopathologic examination of glandular tissue obtained by either minor or major salivary gland biopsies. Serologic criteria play an additional diagnostic role. The different radiological modalities allow the exclusion of other inflammatory and neoplastic processes that can mimic the initial stages of Mikulicz's disease and Sjögren's syndrome. Streszczenie Choroba Mikulicza i zespół Sjögrena zajmują gruczoły ślinowe. Charakteryzują się naciekami limfocytarnymi w zajętych gruczołach zewnątrzwydzielniczych, co prowadzi do ich obrzęku i dysfunkcji. Chociaż oba te schorzenia cechuje podobny obraz kliniczny, obecnie są odmiennie klasyfikowane i wymagają innego leczenia wielospecjalistycznego. W artykule przedstawiono chorobę Mikulicza oraz zespół Sjögrena i porównano je ze sobą. Omówiono ich główne kryteria kliniczne, histopatologiczne i serologiczne, a także metody stosowane w diagnostyce. Badanie histopatologiczne tkanki gruczołowej pobranej z małych lub dużych gruczołów ślinowych jest najpewniejszą metodą diagnostyczną. Badania serologiczne odgrywają dodatkową rolę. Różne metody radiologiczne pozwalają na wykluczenie procesów nowotworowych i zapalnych, które w początkowych fazach choroby mogą naśladować zespół Sjögrena i chorobę Mikulicza.

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Section: Xerostomia and Xerophthalmia In Differentiative Diagnosis Ofmentioning

confidence: 99%

Section: Epidemiological Pattern and Clinical Presentationmentioning

confidence: 99%

Section: Xerostomia and Xerophthalmia In Differentiative Diagnosis Ofmentioning

confidence: 99%

mentioning

confidence: 99%

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Mikulicz’s disease and Sjögren’s syndrome as the main autoimmune disorders involving salivary glands

Kamiński¹

2020

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Expression profile of genes regulating cellular response to cytokine stimulus in Sjögren’s syndrome

Błochowiak¹,

Nawrocki²,

Celichowski³

et al. 2022

Medical Journal of Cell Biology

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The existence of abnormal cytokine profile in Sjögren’s syndrome (SS) may contribute to find potential SS biomarkers and accompanying comorbidities. We aimed to investigate and compare gene expressions in the labial salivary glands of SS and of healthy subjects (HS) by means of microarray analysis. The study group comprised 8 SS patients and 8 HS in microarray analysis. The relative gene expression changes were validated with real time quantitative polymerase chain reaction in 25 SS and 20 HS. Among the differently expressed genes belonging to the “cellular response to cytokine stimulus”, “cytokine-mediated signaling pathway” and “innate immune response” ontology groups with a fold change >1.5 and with a p value < 0.05, the adiponectin, C1Q and collagen domain containing (ADIPOQ), S100 calcium binding protein A9 (S100A9), leptin receptor (LEPR), and fatty acid binding protein 4 (FABP4) gene expressions in SS group were higher than in HS. Increased expression of the assessed genes are determined by the presence of SS and the accompanying inflammation and may be a valuable diagnostic biomarker of SS. Their selected systemic effects may suggest their role as potential prognostic biomarkers of the risk of accelerated atherosclerosis and cardiovascular complications in SS.

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Introductory Chapter: Autoimmune Epithelitis - Discussion about Sjögren’s Syndrome and Primary Biliary Cholangitis

Cited by 2 publications

References 35 publications

Mikulicz’s disease and Sjögren’s syndrome as the main autoimmune disorders involving salivary glands

Mikulicz’s disease and Sjögren’s syndrome as the main autoimmune disorders involving salivary glands

Expression profile of genes regulating cellular response to cytokine stimulus in Sjögren’s syndrome

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