Introductory Chapter: Having a Brain is Not Necessary to Get Cancer… but Indispensable to Fight It

Preventing Cancer by Inhibiting Ornithine Decarboxylase: A Comparative Perspective on Synthetic vs. Natural Drugs

“…The World Health Organization (WHO) states that cancer is the leading cause of premature death globally, resulting in an estimated 7.6 million deaths. By 2030, this number may rise to 13.1 million deaths worldwide [2–3] . It is a condition caused by abnormal cellular reproduction, in which cells multiply and expand uncontrollably without any restrictions and have the ability to infect many body parts [4] .…”

“…By 2030, this number may rise to 13.1 million deaths worldwide. [2][3] It is a condition caused by abnormal cellular reproduction, in which cells multiply and expand uncontrollably without any restrictions and have the ability to infect many body parts. [4] Typically, cancer is characterized by uncontrolled and abnormal cell growth and division of malignant cells.…”

“…[5][6] Carcinogens, can be found in chemical compounds, natural products, latex, cosmetic products, and food substances, directly or indirectly, through the environment and industrial waste. [2] About 5-10 % of cancer deaths worldwide are caused by inherited genetic abnormalities or germline mutations. [6] These mutations are linked to the Myc-oncogene, a transcription factor important in the development of various cancers by increasing Myc expression and promoting the growth and proliferation of cells through the division of polyamines.…”

“…Most cancer cases, about 90–95 %, are caused by genetic variations resulting from environmental and habitual factors [5–6] . Carcinogens, can be found in chemical compounds, natural products, latex, cosmetic products, and food substances, directly or indirectly, through the environment and industrial waste [2] . About 5–10 % of cancer deaths worldwide are caused by inherited genetic abnormalities or germline mutations [6] .…”

Informatics Approaches for Predicting, Understanding, and Testing Cancer Drug Combinations

“…Similar to single drugs, the identification of drug combinations is largely driven by serendipity or a trial-and-error process using high-throughput screening [18]. However, such a brute-force search strategy becomes quickly infeasible, as the number of possible drug combinations may go up exponentially beyond what any automated experimentation can handle.…”