Introductory Chapter: Reduce the Gap from Bench to Bedside for Nanomedicines Increasing the Stability to Long-Term Storage

Musumeci, Teresa; Pignatello, Rosario

doi:10.5772/intechopen.76541

Cited by 2 publications

(2 citation statements)

References 13 publications

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“…Thus, the amount of cryoprotectant should be selected as a function of total superficial area correlated to the size of the particles. A critical concentration for each cryoprotector seems to exist, above which an additional amount is prejudicial in many cases [61]. Accordingly, we suppose that 5% w/v mannitol is sufficient to cover a NC surface exerting a cryoprotective effect.…”

Section: Freeze-drying Process For Ncs Long Term Storagementioning

confidence: 99%

Optimization of Curcumin Nanocrystals as Promising Strategy for Nose-to-Brain Delivery Application

et al. 2020

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Intranasal (IN) drug delivery is recognized to be an innovative strategy to deliver drugs to the Central Nervous System. One of the main limitations of IN dosing is the low volume of drug that can be administered. Accordingly, two requirements are necessary: the drug should be active at a low dosage, and the drug solubility in water must be high enough to accommodate the required dose. Drug nanocrystals may overcome these limitations; thus, curcumin was selected as a model drug to prepare nanocrystals for potential IN administration. With this aim, we designed curcumin nanocrystals (NCs) by using Box Behnken design. A total of 51 formulations were prepared by the sonoprecipitation method. Once we assessed the influence of the independent variables on nanocrystals’ mean diameter, the formulation was optimized based on the desirability function. The optimized formulation was characterized from a physico-chemical point of view to evaluate the mean size, zeta potential, polidispersity index, pH, osmolarity, morphology, thermotropic behavior and the degree of crystallinity. Finally, the cellular uptake of curcumin and curcumin NCs was evaluated on Olfactory Ensheathing Cells (OECs). Our results showed that the OECs efficiently took up the NCs compared to the free curcumin, showing that NCs can ameliorate drug permeability.

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