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Rd, Altman

doi:10.1016/0049-0172(90)90077-s

Seminars in Arthritis and Rheumatism

1990

DOI: 10.1016/0049-0172(90)90077-s

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Introductory remarks

Altman Rd

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Effect of Some Anti-Inflammatory Drugs on Human Neutrophil Chemotaxis

1994

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The effects of piroxicam, tenoxicam, diclofenac sodium, acetylsalicylic acid and tiaprofenic acid on the chemotaxis and random migration of human polymorphonuclear leukocytes were investigated, using zymosan-activated serum as chemo-attractant, with a modified Boyden chamber technique. All five compounds significantly reduced chemotaxis. The random migration of polymorphonuclear leukocytes was inhibited by piroxicam, diclofenac sodium and tiaprofenic acid but not by tenoxicam or acetylsalicylic acid. The inhibitory effect of these non-steroidal anti-inflammatory drugs on polymorphonuclear leukocyte chemotaxis and on random migration was generally dose-dependent. The results suggest that the drugs studied may have a direct effect on polymorphonuclear leukocyte chemotaxis and that this activity may contribute to their anti-inflammatory properties.

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Effect of Some Anti-Inflammatory Drugs on Human Neutrophil Chemotaxis

1994

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Nonunion of the femoral diaphysis

Giannoudis¹,

MacDonald²,

Matthews³

et al. 2000

The Journal of Bone and Joint Surgery

263

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We assessed factors which may affect union in 32 patients with nonunion of a fracture of the diaphysis of the femur and 67 comparable patients whose fracture had united. These included gender, age, smoking habit, the use of non-steroidal anti-inflammatory drugs (NSAIDs) the type of fracture (AO classification), soft-tissue injury (open or closed), the type of nail, the mode of locking, reaming nu non-reaming, infection, failure of the implant, distraction at the fracture site, and the time to full weight-bearing. Patients with severe head injuries were excluded. Both groups were comparable with regard to gender, Injury Severity Score and soft-tissue injury. There was no relationship between the rate of union and the type of implant, mode of locking, reaming, distraction or smoking. There were fewer cases of nonunion in more comminuted fractures (type C) and in patients who were able to bear weight early. There was a marked association between nonunion and the use of NSAIDs after injury (p = 0.000001) and delayed healing was noted in patients who took NSAIDs and whose fractures had united.

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Introductory remarks

Cited by 2 publications

References 0 publications

Effect of Some Anti-Inflammatory Drugs on Human Neutrophil Chemotaxis

Effect of Some Anti-Inflammatory Drugs on Human Neutrophil Chemotaxis

Nonunion of the femoral diaphysis

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