Intubation Conditions and Time-Course of Action of Org 9426

Rocuronium combined with i.v. lidocaine for rapid tracheal intubation

“…We have observed that groups in which rocuronium was used had also clinically acceptable intubating conditions. These results are similar to reports of other studies (10)(11)(12)(13)(14)(15). However, as seen in Table 5, 48% of patients in group R 60 had good intubating conditions with slight bucking or coughing.…”

“…Suppression of pharyngeal and laryngeal reflexes permits the maintenance of airways in light planes of anesthesia. Lidocaine has been shown to reduce coughing and bucking when propofol and alfentanil are used for tracheal intubation without neuromuscular blockade (7,(9)(10)(11)(12)(13)(16)(17)(18)(19). The degree of suppression of the cough reflex correlates with the plasma concentration (20).…”