Intubation Studies of the Human Small Intestine. Xxi. A Method for Measuring Intra-Luminal Pressures and Its Application to the Digestive Tract 1

Abbott, W. Osler; Hartline, H. K.; Hervey, J. P.; Ingelfinger, Franz J.; Rawson, Annette; Zetzel, Louis

doi:10.1172/jci101387

Cited by 23 publications

(5 citation statements)

References 5 publications

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“…Additionally, the BP and BWT for segments with an anastomosis were similar to normal intestine. The intraluminal pressures reached in this study far exceed those reported to cause ischaemic damage to the equine mucosa experimentally (18 cmH2O [13.2 mmHg] for 120 min) (Dabareiner et al 2001), those noted in nonsurviving clinical cases with small intestinal obstruction (average 15 cmH2O [11 mmHg]) (Allen et al 1986), and those noted in human subjects with experimentally obstructed small intestine (50 cmH2O [36.78 mmHg]) (Abbott et al 1943). Therefore, anastomoses constructed using these suture patterns are unlikely to fail in clinical cases due to excessive intraluminal pressures.…”

Section: Discussioncontrasting

confidence: 62%

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Ex vivo comparison of three hand sewn end‐to‐end anastomoses in normal equine jejunum

Sherlock¹,

Lee

Mueller

et al. 2011

Equine Veterinary Journal

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) for end-to-end equine jejunojejunostomies. Methods: End-to-end jejunojejunostomies were constructed using 2C (n = 7), 1L (n = 7) and 1C (n = 7) in harvested equine jejunum and construction times were recorded. Anastomosed and control segments were distended with gas until failure. Intraluminal pressure at failure and mode of failure were recorded. Lumen size reduction was calculated as a percentage decrease from control jejunum. Results were compared using an ANOVA and P<0.05 was considered significant. Results: The 1C anastomoses were faster to construct than the 1L anastomoses, which were faster to construct than the 2C anastomoses. There were no differences in bursting pressures between the different anastomoses and control jejunum. All anastomoses decreased lumen size from control values but there were no differences in lumen reduction between types of anastomoses. Conclusions: Single layer anastomoses are faster to construct than double layer anastomoses, with the 1C being fastest. Single layer anastomoses are as strong and result in comparable lumen size reduction as traditional 2C anastomoses. Potential relevance: As the 1C anastomosis results in less exposed potentially adhesiogenic suture material than the 1L while providing adequate strength and similar luminal size reduction, the 1C may be better for equine small intestine anastomosis and further in vivo studies are warranted.

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Section: Discussioncontrasting

confidence: 62%

“…2001), those noted in nonsurviving clinical cases with small intestinal obstruction (average 15 cmH 2 O [11 mmHg]) (Allen et al . 1986), and those noted in human subjects with experimentally obstructed small intestine (50 cmH 2 O [36.78 mmHg]) (Abbott et al . 1943).…”

Section: Discussionmentioning

confidence: 90%

Ex vivo comparison of three hand sewn end‐to‐end anastomoses in normal equine jejunum

Sherlock¹,

Lee

Mueller

et al. 2011

Equine Veterinary Journal

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“…12 When pressure was increased above these values, the frequency of propagating contractions increased and their amplitudes decreased, as previously reported. 12 When pressure was increased above these values, the frequency of propagating contractions increased and their amplitudes decreased, as previously reported.…”

Section: Types Of Activitysupporting

confidence: 72%

“…The normal resting baseline intraluminal pressure in the rat jejunum is 2-4 mmHg, 10 which is similar to values in dog 11 and human. 12 When pressure was increased above these values, the frequency of propagating contractions increased and their amplitudes decreased, as previously reported. 10 However, the speeds of contraction showed little variation between 2 and 8 mmHg baseline pressure (Table 1).…”

Section: Types Of Activitysupporting

confidence: 72%

Motor patterns and propulsion in the rat intestine in vivo recorded by spatio‐temporal maps

Ferens

Bogeski

et al. 2005

Neurogastroenterology Motil

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We have used spatio-temporal maps derived from video images to investigate propagated contractions of the rat small intestine in vivo. The abdomen, including an exteriorized segment of jejunum, was housed in a humid chamber with a viewing window. Video records were converted to spatio-temporal maps of jejunal diameter changes. Intraluminal pressure and fluid outflow were measured. Contractions occupied 3.8 +/- 0.2 cm of intestine and propagated anally at 3.1 +/- 0.2 mm s(-1) when baseline pressure was 4 mmHg. Contractions at any one point lasted 8.7 +/- 0.6 s. Contractions often occurred in clusters; within cluster frequencies were 2.28 +/- 0.04 min(-1). Pressure waves, with amplitudes greater than about 9 mmHg, expelled fluid when the baseline pressure was 4 mmHg. In the presence of L-NAME, circular muscle contractions occurred at a high frequency, but they were not propagated. We conclude that video recording methods give good spatio-temporal resolution of intestinal movement when applied in vivo. They reveal neurally-mediated propulsive contractions, similar to those previously recorded from intestinal segments in vitro. The propagated contractions had speeds of propagation that were slower and frequencies of occurrence that were less than speeds and frequencies of slow waves in the rat small intestine.

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“…In these experiments, talnetant failed to alter peristalsis induced by the lower intraluminal pressures of 1–3 cmH 2 O; both average volume ejected with each peristaltic contraction and the number of peristaltic contractions were unaffected. These intraluminal pressures appear optimal, as the highest volumes of intraluminal fluid ejection and numbers of contractions during peristalsis occurred at pressures in the range that normally occur in humans and animals, in vivo (e.g., Abbott et al. , 1943; Fink, 1959; Bogeski et al.…”

Section: Discussionmentioning

confidence: 99%

Modulation of peristalsis by NK₃ receptor antagonism in guinea‐pig isolated ileum is revealed as intraluminal pressure is raised

Sanger

Tuladhar

Brown

et al. 2007

Auton Autocoid Pharmacol

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1. NK(3) tachykinin receptors mediate slow excitatory transmission in the enteric nervous system and play a role in reflexes induced by the intestinal stretch or mucosal compression. However, there is little evidence to suggest that these receptors are important in peristalsis. We have examined the effects of the NK(3) receptor antagonist, talnetant, on peristalsis in guinea-pig isolated ileum induced by optimal and by supra-maximal distension pressures. 2. At the guinea-pig NK(3) receptor, talnetant was shown to have high affinity (pK(B) 8.8) and selectivity over the guinea-pig NK(1) and NK(2) receptors. 3. Peristaltic waves in the ileum elicited by optimal distension pressures (1-3 cmH(2)O) were unaffected by talnetant at a supra-maximal concentration (250 nm). 4. Distension at a higher pressure (4 cmH(2)O) induced peristalsis in which there was incomplete closure of the lumen during each peristaltic wave and an increase in the periods of inactivity observed between bursts of peristaltic activity. The addition of talnetant (250 nm) increased the number of peristaltic events by reducing these periods of inactivity and thus, increased the productivity of the peristaltic reflex. 5. The data suggest that NK(3) receptors are not involved in the modulation of peristaltic movements by physiological stimuli, but they may have a role in modulation of reflexes in extreme or pathological conditions.

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Intubation Studies of the Human Small Intestine. Xxi. A Method for Measuring Intra-Luminal Pressures and Its Application to the Digestive Tract 1

Cited by 23 publications

References 5 publications

Ex vivo comparison of three hand sewn end‐to‐end anastomoses in normal equine jejunum

Ex vivo comparison of three hand sewn end‐to‐end anastomoses in normal equine jejunum

Motor patterns and propulsion in the rat intestine in vivo recorded by spatio‐temporal maps

Modulation of peristalsis by NK₃ receptor antagonism in guinea‐pig isolated ileum is revealed as intraluminal pressure is raised

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Intubation Studies of the Human Small Intestine. Xxi. A Method for Measuring Intra-Luminal Pressures and Its Application to the Digestive Tract 1

Cited by 23 publications

References 5 publications

Ex vivo comparison of three hand sewn end‐to‐end anastomoses in normal equine jejunum

Ex vivo comparison of three hand sewn end‐to‐end anastomoses in normal equine jejunum

Motor patterns and propulsion in the rat intestine in vivo recorded by spatio‐temporal maps

Modulation of peristalsis by NK3 receptor antagonism in guinea‐pig isolated ileum is revealed as intraluminal pressure is raised

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Modulation of peristalsis by NK₃ receptor antagonism in guinea‐pig isolated ileum is revealed as intraluminal pressure is raised