Intuitive eating is associated with elevated levels of circulating omega-3-polyunsaturated fatty acid-derived endocannabinoidome mediators

Rochefort, Gabrielle; Provencher, Véronique; Castonguay-Paradis, Sophie; Perron, Julie; Lacroix, Sébastien; Martin, Cyril; Flamand, Nicolas; Marzo, Vincenzo Di; Veilleux, Alain

doi:10.1016/j.appet.2020.104973

Cited by 8 publications

(9 citation statements)

References 55 publications

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“…Our investigation of the associations between plasma eCBome mediator levels and appetite and satiety measures were motivated by previously reported roles of some eCBome mediators and receptors on regulating food intake [ 51 ] ( Figure 4 ). The amount of food that could be eaten (DQuaN) was inversely related to levels of LEA, while pre-meal desire to eat (BEnvM) and feeling of hunger (BSenF) were inversely related to DPA and both DPA and DHA, respectively.…”

Section: Resultsmentioning

confidence: 99%

Oral Capsaicinoid Administration Alters the Plasma Endocannabinoidome and Fecal Microbiota of Reproductive-Aged Women Living with Overweight and Obesity

et al. 2021

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Capsaicinoids, the pungent principles of chili peppers and prototypical activators of the transient receptor potential of the vanilloid type-1 (TRPV1) channel, which is a member of the expanded endocannabinoid system known as the endocannabinoidome (eCBome), counteract food intake and obesity. In this exploratory study, we examined the blood and stools from a subset of the participants in a cohort of reproductive-aged women with overweight/obesity who underwent a 12-week caloric restriction of 500 kcal/day with the administration of capsaicinoids (two capsules containing 100 mg of a capsicum annuum extract (CAE) each for a daily dose of 4 mg of capsaicinoids) or a placebo. Samples were collected immediately before and after the intervention, and plasma eCBome mediator levels (from 23 participants in total, 13 placebo and 10 CAE) and fecal microbiota taxa (from 15 participants in total, 9 placebo and 6 CAE) were profiled using LC–MS/MS and 16S metagenomic sequencing, respectively. CAE prevented the reduced caloric-intake-induced decrease in beneficial eCBome mediators, i.e., the TRPV1, GPR119 and/or PPARα agonists, N-oleoyl-ethanolamine, N-linoleoyl-ethanolamine and 2-oleoyl-glycerol, as well as the anti-inflammatory N-acyl-ethanolamines N-docosapentaenyl-ethanolamine and N-docosahexaenoyl-ethanolamine. CAE produced few but important alterations in the fecal microbiota, such as an increased relative abundance of the genus Flavonifractor, which is known to be inversely associated with obesity. Correlations between eCBome mediators and other potentially beneficial taxa were also observed, thus reinforcing the hypothesis of the existence of a link between the eCBome and the gut microbiome in obesity.

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Section: Resultsmentioning

confidence: 99%

Oral Capsaicinoid Administration Alters the Plasma Endocannabinoidome and Fecal Microbiota of Reproductive-Aged Women Living with Overweight and Obesity

et al. 2021

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“…Centrally, it is related in the control of hedonic eating, or eating based on pleasure and reward network, 11 which can influence dietary intake. A prior study found a positive correlation between intuitive eating, defined as eating behaviors based on physical or physiological signaling, and other ω‐3 PUFA compounds independent of body mass index, age, or oral fatty acid intake 38 . However, there were no significant changes in AEA, 2‐AG, OEA, and PEA in a healthy population 38 .…”

Section: Cannabis and Nutritionmentioning

confidence: 97%

Nutrition, endocannabinoids, and the use of cannabis: An overview for the nutrition clinician

Russell,

Condo,

DeFlorville

2024

Nut in Clin Prac

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The endocannabinoid system (ECs) is composed of multiple signaling compounds and receptors within the central and peripheral nervous system along with various organs, including the gut, liver, and skeletal muscle. The ECs has been implicated in metabolism, gut motility, and eating behaviors. The ECs is altered in disease states such as obesity. Recent studies have clarified the role of the gut microbiome and nutrition on the ECs. Exogenous cannabinoid (CB) use, either organic or synthetic, stimulates the ECs through CB1 and CB2 receptors. However, the role of CBs is unclear in regard to nutrition optimization or to treat disease states. This review briefly summarizes the effect of the ECs and exogenous CBs on metabolism and nutrition. With the increased legalization of cannabis, there is a corresponding increased use in the United States. Therefore, nutrition clinicians need to be aware of both the benefits and harm of cannabis use on overall nutrition status, as well as the gaps in knowledge for future research and guideline development.

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“…The regulation of food intake is usually divided into homeostatic feeding, that aims to maintain the body weight and metabolic function, and hedonic feeding, which is primarily driven by sensory perception or pleasure (Rochefort et al, 2021). Hedonic regulation is given by sensory and rewarding stimuli, which can prevail over the homeostatic control, leading to excessive consumption of high-palatability food, even when energy requirements have been met, contributing to weight gain and obesity (Díaz-Rúa et al, 2020).…”

Section: Regulation Of Appetite and Satietymentioning

confidence: 99%

Endocannabinoid system and eating behavior / Sistema endocannabinoide y conducta alimentaria

Ramírez-Emiliano,

Ortega-Barrón,

Caudillo-Ortega

et al. 2024

Rev. Mex. Trast. Alim.

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The objective of this systematic review was to investigate previously published literature that examined the effect of hypercaloric diet on the endocannabinoid system, eating behavior, and the development of obesity. In the present review, we analyzed and described the evidence that suggests that the regulation of the endocannabinoid system through the activation of the receptors for cannabinoid type 1 (CB1R) and type 2 (CB2R) by modulating the production of anandamide, 2-arachidonoylglycerol (2-AG) and oleamide, influence the appetite and satiety centers, inducing or inhibiting the consumption of hypercaloric foods such as Western diet; thereby altering the production of hormones like the ghrelin, insulin, peptide YY and leptin. However, the adequate doses of pure cannabinoids and/or the cannabinoid-enriched Cannabis herbal extracts for the treatment of eating disorders like anorexia and/or obesity, neither for disorders of the mood, have not determined.

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Intuitive eating is associated with elevated levels of circulating omega-3-polyunsaturated fatty acid-derived endocannabinoidome mediators

Cited by 8 publications

References 55 publications

Oral Capsaicinoid Administration Alters the Plasma Endocannabinoidome and Fecal Microbiota of Reproductive-Aged Women Living with Overweight and Obesity

Oral Capsaicinoid Administration Alters the Plasma Endocannabinoidome and Fecal Microbiota of Reproductive-Aged Women Living with Overweight and Obesity

Nutrition, endocannabinoids, and the use of cannabis: An overview for the nutrition clinician

Endocannabinoid system and eating behavior / Sistema endocannabinoide y conducta alimentaria

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