Introduction:Adult intussusception is an infrequent cause of intestinal obstruction and differs from childhood intussusception in its presentation, etiology, and treatment. Almost 90% of adult intussusceptions are secondary to a pathological condition that serves as a lead point and most of them require surgical intervention. Method: Computed tomography (CT) is the most sensitive diagnostic modality which distinguishes intussusceptions with and without a lead point. This paper presents the clinical presentation and etiopathogenesis of adult intussusception as demonstrated by CT. Observation and results: Five cases of adult intussusception were evaluated and the various etiologies included an intestinal polyp, bowel wall leiomyoma, jejunal lipoma, calcified lymph and idiopathic causes. Conclusion: Adult intussusception is a rare but challenging condition for the surgeon. Diagnosis is usually missed because of nonspecific and subacute symptoms. With the advent of MDCT in imaging of acute abdominal emergency, the detection of intussusception has increased. Figs 1A and B: CT (A-plain) and (B-contrast) shows a long-segment intussusception in the distal ileum (short arrow), ileocecal junction, cecum, and proximal part of transverse colon secondary to an enhancing intraluminal polypoidal lesion (long arrow). Case 1: A 58-year-old female presented with acute pain abdomen A B dIscussIon Adult intussusception is unusual, and its causes are varied. Almost 90% of adult intussusceptions are secondary to a pathological 24 Figs 2A and B: CT (A-plain) and (B-contrast) shows a well-defined lesion giving target appearance (short arrow) involving the distal ileum and colon. A well-defined lesion of soft tissue attenuation (long arrow) later proven to be leiomyoma was found to be the cause of intussusception. Case 2: A 37-year-old female presented with acute pain abdomen A B Figs 3A and B: CT (A-plain) and (B-contrast) shows evidence of a concentric doughnut-shaped lesion (long arrow) involving the distal ileum and ascending colon with a dense intra luminal focus as the contributory cause, which was later found to be a calcified lymph node (short arrow). Case 3: A 50-year-old male patient presented with acute abdomen A B A B Figs 4A and B: CT (A-plain) and (B-contrast) shows a telescoping of the fourth part of the duodenum and mesentery into the proximal jejunum (short arrow). A lesion of fatty attenuation (long arrow) which formed the leading point attributed to the cause. Case 4: A 50-year-old female presented with pain abdomen