Intussusception in infancy and childhood a review of 400 cases

Evaluation of Anatomic Changes in Young Children with Natural Rotavirus Infection: Is Intussusception Biologically Plausible?

“…By chance, we observed by ultrasound, during the present study, a transient intussusception in a child with rotavirus infection 6). Published data [14,21] and anecdotal reports from pediatric surgeons support the notion that the bowel tissue in young children transiently telescopes without leading to clinical intussusception. Our results suggest that this may occur in rotavirus infection.…”

“…Our results establish that rotavirus infection in young children affects the bowel wall, most notably by increasing wall thickness in the distal ileum and by enlarging mesenteric lymph node size. The effect of rotavirus on the bowel wall is a possible mechanism for virally induced intussusception, as has been postulated in studies of adenovirus and of intussusception [14][15][16][17][18][19][20]. These prior studies documented the presence of adenovirus in the mesenteric lymph nodes of patients with intussusception, and 1 documented the presence of adenovirus in the appendiceal tissue within the bowel wall [24].…”

“…Our results suggest that this may occur in rotavirus infection. Enlarged mesenteric nodes and nodal aggregates are often observed during the surgical correction of intussusception [14,17,19]. Konno et al [22], using autopsy material, reported that hyperplasia of the intestinal lymphoid tissue occurs in acute gastroenteritis caused by rotavirus infection.…”

Rotavirus infection and intussusception in Tunisian children: implications for use of attenuated rotavirus vaccines

“…Predisposing conditions, such as Meckel's diverticulum, Henoch-Schoenlein purpura, intestinal tumors, parasitic infestations, and ingestion of foreign bodies, account for less than 5% of cases [6,33]. Enlarged lymph nodes, often observed on laparotomy [34], have been hypothesized to play a role in at least some cases of intussusception [35][36][37]. The observation of mesenteric lymphadenopathy or inflamed Peyer's patches in a significant proportion of cases pointed to an inflammatory process [1].…”

Intussusception: factors related to treatment.

“…1 3The risk of perforating the bowel during barium enema reduction is less than 1%,5 6 and bowel resection because of irreducibility or non-viability is necessary in about 12%. [7][8][9][10][11] Signs of peritonitis or bowel perforation are absolute contraindications to hydrostatic reduction, but there is no consensus about the duration of symptoms (over 24 or 48 hours) and evidence of small bowel obstruction. Several other factors have been correlated with the outcome of treatment, including age, the presence of vomiting or rectal Table I Distribution offactors in four treatment groups bleeding, the absence of abdominal pain, a high white cell count, the type of intussusception, localisation of the apex, and the presence of a leading point.…”