Inulin-type fructans change the gut microbiota and prevent the development of diabetic nephropathy

Luo, Lina; Luo, Jing; Cai, Yueting; Fu, Menglu; Li, Wenhua; Shi, Lili; Liu, Jingrui; Dong, Ruolan; Xu, Xizhen; Tu, Lei; Yang, Yan

doi:10.1016/j.phrs.2022.106367

Cited by 47 publications

(28 citation statements)

References 60 publications

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“…To the best of our knowledge, we did not find any direct or indirect correlation among these bacteria ( Candidatus_Saccharimonas, Candidatus_Actinomarina, Mucispirillum , and Helicobacter ) and OGA/OGT and O-GlcNAc. But we found a couple of flora that were associated with SCFAs ( Wang et al, 2020 ; Gu et al, 2021 ; Liu Q. et al, 2021 ; Luo L. et al, 2022 ), glucose metabolism ( Gao et al, 2020 ; Li L. et al, 2022 ; Luo L. et al, 2022 ; Ma Q. et al, 2022 ), glycolysis ( Feichtinger et al, 2017 ; Zhou et al, 2021 ; Li L. et al, 2022 ), bile acids ( Alizadeh and Raufman, 2022 ; Jian et al, 2022 ; Yin et al, 2022 ; Yuan et al, 2022 ) and other aspects. The intracerebral glucose metabolism and glycolysis, which produced the major donor substrate for O-GlcNAcylation ( Liu X. et al, 2021 ), were regulated directly by intestinal microbiota and their metabolites.…”

Section: Discussionmentioning

confidence: 87%

Liuwei Dihuang formula ameliorates chronic stress-induced emotional and cognitive impairments in mice by elevating hippocampal O-GlcNAc modification

Huang

Wang²,

Liu³

et al. 2023

Front. Neurosci.

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A substantial body of evidence has indicated that intracerebral O-linked N-acetyl-β-D-glucosamine (O-GlcNAc), a generalized post-translational modification, was emerging as an effective regulator of stress-induced emotional and cognitive impairments. Our previous studies showed that the Liuwei Dihuang formula (LW) significantly improved the emotional and cognitive dysfunctions in various types of stress mouse models. In the current study, we sought to determine the effects of LW on intracerebral O-GlcNAc levels in chronic unpredictable mild stress (CUMS) mice. The dynamic behavioral tests showed that anxiety- and depression-like behaviors and object recognition memory of CUMS mice were improved in a dose-dependent manner after LW treatment. Moreover, linear discriminate analysis (LEfSe) of genera abundance revealed a significant difference in microbiome among the study groups. LW showed a great impact on the relative abundance of these gut microbiota in CUMS mice and reinstated them to control mouse levels. We found that LW potentially altered the Uridine diphosphate-N-acetylglucosamine (UDP-GlcNAc) biosynthesis process, and the abundance of O-GlcNAcase (OGA) and O-GlcNAc transferase (OGT) in CUMS mice, which was inferred using PICRUSt analysis. We further verified advantageous changes in hippocampal O-GlcNAc modification of CUMS mice following LW administration, as well as changes in the levels of OGA and OGT. In summary, LW intervention increased the levels of hippocampal O-GlcNAc modification and ameliorated the emotional and cognitive impairments induced by chronic stress in CUMS mice. LW therefore could be considered a potential prophylactic and therapeutic agent for chronic stress.

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Section: Discussionmentioning

confidence: 87%

Liuwei Dihuang formula ameliorates chronic stress-induced emotional and cognitive impairments in mice by elevating hippocampal O-GlcNAc modification

Huang

Wang²,

Liu³

et al. 2023

Front. Neurosci.

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“…Furthermore, research (Li et al, 2020) has shown that a mixture of Lactobacilli species can modulate the gut microbiota in mice fed a high‐fat diet, resulting in the increased production of SCFAs (such as acetic acid and butyric acid), thereby regulating lipid metabolism in adipose tissue and mitigating hepatic lipid accumulation to prevent obesity. Candidatus Saccharimonas , an acid‐producing bacterium, has been reported to possess significant potential in ameliorating host metabolic disorders, inflammation, and immune response (Luo et al, 2022; Ma et al, 2023). The Prevotella genus primarily participates in carbohydrate and monosaccharide metabolism, leading to the production of SCFAs that confer beneficial effects on intestinal health (Atzeni et al, 2021; Zhao et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Investigation of the therapeutic effect of Hedan tablets on high‐fat diet‐induced obesity in rats by GC–MS technology and 16S ribosomal RNA gene sequencing

Pan,

Zhang,

Qiao

et al. 2024

Biomedical Chromatography

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Obesity is a persistent metabolic condition resulting from the excessive accumulation or abnormal distribution of body fat. This study aimed to establish an experimental rat model of obesity. The efficacy of treating obesity with Hedan tablets (HDT) was assessed by monitoring changes in weight, blood lipid levels, analyzing inflammatory factors, evaluating organ indices, and observing liver tissue pathology. Furthermore, we utilized 16S ribosomal RNA gene sequencing technology to explore changes in intestinal flora. In addition, GC–MS was used to measure fecal short‐chain fatty acid (SCFA) content. The onset of obesity led to a significant decrease in the relative abundance of beneficial bacteria. Conversely, the administration of HDT demonstrated a substantial ability to increase the relative abundance of beneficial bacteria. Obesity resulted in a noteworthy reduction in total SCFAs, a trend significantly reversed in the HDT group. Through correlation analysis, it was determined that HDT mitigated the inflammatory response and improved blood lipid levels by augmenting the abundance of Lactobacillus, Limosilactobacillus, Ruminococcus, and Enterococcus. These particular intestinal flora were identified as regulators of SCFA metabolism, thereby ameliorating metabolic abnormalities associated with obesity. Moreover, HDT intervention elevated the overall fecal concentration of SCFAs, thereby improving metabolic disorders induced by obesity. The anti‐obesity effects of HDT are likely attributable to their capacity to influence the composition of intestinal flora and boost SCFA levels in the intestine.

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“…Te research found dietary fber could prevent DN by changing the microbes in the intestines, thereby changing the content of short-chain fatty acids [41]. Recent studies have shown that inulin-type fructans (a dietary fber) played a kidney-protective role by regulating the gut microbiome and increasing acetic acid production [42]. Our results found that T-fber could effectively alleviate the related pathology of DN, but it has not been tested whether T-fber can cause changes in the intestinal fora in Db/db mice.…”

Section: Discussionmentioning

confidence: 99%

T-Fiber, A Highland Barley Fiber-Rich Powder, Alleviates Hyperglycemia and Improves Kidney Pathology in Db/db Mice

Yang

Ma²,

Han³

et al. 2023

Journal of Food Biochemistry

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The role of dietary fiber in highland barley in lowering blood lipids has been continuously studied in recent years. However, its effects on diabetes and diabetic nephropathy are rarely studied. Considering that highland barley bran is rich in dietary fiber, the effective use of dietary fiber in highland barley bran can not only alleviate the symptoms of diabetes but also improve the local economy. This article aimed to study the effects of highland barley fiber-rich powder (T-fiber) with a high-quality natural dietary fiber ratio (insoluble fiber/soluble fiber = 3 : 1) on the symptoms of hyperglycemia in a diabetic mouse model. Compared with the model group’s blood glucose level (30.80 mmol/L), glucose tolerance (28.57 mmol/L), and glycosylated serum protein (2.43 mmol/L), T-fiber presented significant reductions in blood glucose (23.69 mmol/L), better glucose tolerance (21.32 mmol/L), and glycosylated serum protein (1.78 mmol/L) in the diabetic mouse model. Meanwhile, T-fiber effectively alleviated hepatocellular lesions. In addition, T-fiber not only improved kidney function by reducing the 24-hour urine output (8.25 ml), urine protein levels (11.51 mg), and serum creatinine (13.80 μmol/L) but also alleviated renal pathology, including glomerular hypertrophy, mesangial expansion, and fibrosis. The above results proved the ability of T-fiber to reduce blood glucose and alleviate liver and renal function in diabetic mice. Altogether, T-fiber is a capable formula for utilizing highland barley bran dietary fiber, which alleviates diabetes symptoms and endows highland barley with promising value.

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Inulin-type fructans change the gut microbiota and prevent the development of diabetic nephropathy

Cited by 47 publications

References 60 publications

Liuwei Dihuang formula ameliorates chronic stress-induced emotional and cognitive impairments in mice by elevating hippocampal O-GlcNAc modification

Liuwei Dihuang formula ameliorates chronic stress-induced emotional and cognitive impairments in mice by elevating hippocampal O-GlcNAc modification

Investigation of the therapeutic effect of Hedan tablets on high‐fat diet‐induced obesity in rats by GC–MS technology and 16S ribosomal RNA gene sequencing

T-Fiber, A Highland Barley Fiber-Rich Powder, Alleviates Hyperglycemia and Improves Kidney Pathology in Db/db Mice

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