Invadopodia: At the cutting edge of tumour invasion

Invadosomes at a glance

“…Finally, the influence of aspects of the ECM, such as substrate rigidity or release of growth factors, is just beginning to be explored. Moreover, the regulation [and eventual possibility of therapeutic modulation (Stylli et al, 2008)] of invadosome-dependent matrix degradation also needs to be studied in more detail. All of these points clearly illustrate the fact that, nearly 30 years after their initial description (David-Pfeuty and Singer, 1980), invadosomes still hold many challenges and surprises in store.…”

Extracellular Matrix Microenvironment in Glioma Progression

“…Invadopodia are actin-rich protrusions of tumor cells with proteolytic activity. The gelatinases and the MT1-MMP localize to or become activated at the invadopodia (Stylli et al 2008). Within the realm of glioma angiogenesis, the gelatinases remain crucial.…”

Syndecan-2 Regulates the Migratory Potential of Melanoma Cells

“…Interestingly, previous studies have shown that melanoma cells acquire the ability to recognize components of the extracellular matrix (ECM) 2 via the ectopic expression of different ECM receptors during invasion of the basement membrane (20). Indeed, invadopodia, the dynamic organelle-like structures that form actinrich protrusions with ECM proteolytic activity, adhere to and digest collagens, laminins, and fibronectin (21). The adhesive * This study was supported by a grant of the Korea Healthcare Technology properties of invadopodia are primarily attributed to integrins, a large family of heterodimeric transmembrane receptors composed of ␣ and ␤ subunits (22).…”