Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelin

Jyonouchi, Soma; Abraham, Valsamma; Orange, Jordan S.; Spergel, Jonathan M.; Gober, Laura; Dudek, Emily; Saltzman, Rushani; Nichols, Kim E.; Cianferoni, Antonella

doi:10.1016/j.jaci.2011.02.026

Cited by 81 publications

(119 citation statements)

References 42 publications

Supporting

Mentioning

108

Contrasting

Unclassified

Order By: Relevance

“…Our studies demonstrate reactivity of human iNKT cells to a component of the GlcCer-enriched lipid fraction from human milk, cow's milk, and soy milk. In addition, milk sphingomylein has been reported as antigenic for iNKT cells from some human donors (39). Humans are the only mammal that continues to drink milk past early life, and consumption of milk or other dietary lipid antigens may play an important role in the regulation of immune responses.…”

Section: Discussionmentioning

confidence: 99%

Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction

Brennan

Tatituri

Heiß

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Significance Invariant natural killer T (iNKT) cells are a specialized subset of T cells that recognizes lipids, rather than peptides, as antigens. Recognition of both endogenous and exogenous lipids by iNKT cells contributes to immune responses during infection, cancer, autoimmune disease, and allergic disease. The endogenous lipids recognized by iNKT cells in most contexts, however, remain unclear. In this report, we characterize the lipid antigen activity found in mammalian milk and tissues. Our data suggest that activity is related to a minor component of the glucosylceramide fraction. Whether contributed from endogenous sources or from the diet, this rare, yet potent lipid activity may play an important role in driving immune responses.

show abstract

Section: Discussionmentioning

confidence: 99%

Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction

Brennan

Tatituri

Heiß

et al. 2014

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

show abstract

“…INKTs specifically recognize self and foreign lipids, including food-derived ones, via their semi-invariant T cell receptor (TCR) [72,73]. Jyonouchi et al showed that iNKTs produce IL-4 and IL-13 upon stimulation with milk-derived lipids and are recruited at the esophagus via RANTES [38].…”

Section: Pathogenesismentioning

confidence: 99%

Eosinophilic Esophagitis and Gastroenteritis

Cianferoni

Spergel

2015

Curr Allergy Asthma Rep

Self Cite

View full text Add to dashboard Cite

Eosinophilic gastrointestinal disease (EGID) can be classified as eosinophilic esophagitis (EoE) when the eosinophilia is limited to the esophagus or as eosinophilic gastritis (EG) if it is limited to the gastric tract, eosinophilic colitis (EC) if it is limited to the colon, and eosinophilic gastroenteritis (EGE) if the eosinophilia involves one or more parts of the gastrointestinal tract. EoE is by far the most common EGID. It is a well-defined chronic atopic disease due to a T helper type 2 (Th2) inflammation triggered often by food allergens. EoE diagnosis is done if an esophageal biopsy shows at least 15 eosinophils per high power field (eos/hpf). Globally accepted long-term therapies for EoE are the use of swallowed inhaled steroids or food antigen avoidance. The treatment of EoE is done not only to control symptoms but also to prevent complications such as esophageal stricture and food impaction. EGE cause non-specific gastrointestinal (GI) symptoms and are diagnosed if esophagogastroduodenoscopy (EGD)/colonoscopy show eosinophilia in one or more parts of the GI tract. They are rare diseases with an unclear pathogenesis, and they are poorly defined in terms of diagnostic criteria and treatment. Before initiating treatment of any EGE, it is imperative to conduct a differential diagnosis to exclude other causes of hypereosinophilia with GI localization. EGE are often poorly responsive to therapy and there is no commonly accepted long-term treatment. EG has many characteristics similar to EoE, including the fact that it is often due to a food allergen-driven Th2 inflammation; transcriptome analysis however shows that it is more a systemic disease and has a different gene signature than EoE. EC is a benign form of delayed food allergy in infant and is instead a difficult-to-treat severe inflammatory condition in older children and adults. EC in the latter groups can be a manifestation of drug allergy or autoimmune disease. Overall EGE, EC, and EG are rare and are a diagnosis of exclusion until more common causes of eosinophilia have been excluded.

show abstract

“…These include bacteria, fungi, protozoa and metazoa that either colonize the mucosa (true or facultative commensals, opportunistic pathogens), or temporarily present themselves at the mucosa following ingestion or inhalation (commensals, pathogens, environmental antigens) ( Table 1). Besides microbes, environmental antigens 64 could be derived from food components too, like milk lipids, 95,96 and from airborne pollen, 83 either directly or after processing by the commensals. Furthermore, microbe-induced changes in the presentation of hostderived self-lipids or the expression levels of CD1d itself could conceivably modulate mucosal iNKT cell responses as well.…”

Section: Discussionmentioning

confidence: 99%

The interaction between invariant Natural Killer T cells and the mucosal microbiota

Hapil¹,

Wingender

2018

Immunology

View full text Add to dashboard Cite

SummaryThe surface of mammalian bodies is colonized by a multitude of microbial organisms, which under normal conditions support the host and are considered beneficial commensals. This requires, however, that the composition of the commensal microbiota is tightly controlled and regulated. The host immune system plays an important role in the maintenance of this microbiota composition. Here we focus on the contribution of one particular immune cell type, invariant Natural Killer T (iNKT) cells, in this process. The iNKT cells are a unique subset of T cells characterized by two main features. First, they express an invariant T-cell receptor that recognizes glycolipid antigens presented by CD1d, a non-polymorphic major histocompatibility complex class I-like molecule. Second, iNKT cells develop as effector/memory cells and swiftly exert effector functions, like cytokine production and cytotoxicity, after activation. We outline the influence that the mucosal microbiota can have on iNKT cells, and how iNKT cells contribute to the maintenance of the microbiota composition.

show abstract

Invariant natural killer T cells from children with versus without food allergy exhibit differential responsiveness to milk-derived sphingomyelin

Cited by 81 publications

References 42 publications

Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction

Activation of iNKT cells by a distinct constituent of the endogenous glucosylceramide fraction

Eosinophilic Esophagitis and Gastroenteritis

The interaction between invariant Natural Killer T cells and the mucosal microbiota

Contact Info

Product

Resources

About