Invasion of laryngeal cartilage by cancer: comparison of CT and MR imaging.

Castelijns, Jonas A.; Gerritsen, G. J.; Kaiser, M. C.; Valk, Jacob; Zanten, T E van; Golding, Remy; Meyer, C; Hattum, L H van; Sprenger, M.; Bezemer, P.D.

doi:10.1148/radiology.167.1.3347723

Cited by 108 publications

(76 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In eleven case, on the other hand, there were false positives on the CT. At our study, to accept the positive involvement of cartilage, we use the criterias of extralaryngeal spread, erosion, lysis and sclerosis. In our study based on 28 cases, we found a sensitivity of 89 % and a specificity of 80 %, positive predictive value, 57%; and negative predictive value, 96%.When compared to the studies in the literature our sensitivity values for cartilage invasion are high, while our specificity values were lower (3,15,16,19).…”

Section: Discussionsupporting

confidence: 45%

“…Several studies in the literature descrıbe that especially in the presence of extralaryngeal spread of tumor, CT can also visualize gross cartilage invasion, and that it not successful in imaging minor cartilage invasion (13,14,15). In the literature sensitivity values of 46-67% and specificity values 87-91% were reported for CT visualization of cartilage retention (3,15,16). Generally the presence of tumor on both sides of the tyhroid cartilage in CT is the only criterion accepted for the verification of neoplastic cartilage invasion (14,17,18).…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Laryngeal Cancer: Radiological Staging by Multislice Computed Tomography and Pathological Correlation

Atlanoğlu

Gürbüz

Açıkalın

et al. 2016

Osmangazi̇ Journal of Medicine

View full text Add to dashboard Cite

To evaluate the accuracy of multislice computed tomography (MSCT) in staging of laryngeal cancer and comparison with histopathological findings. Twenty-eight patients diagnosed with laryngeal cancer and underwent surgical treatment were staged according to radiological and histopathological examination. The diagnostic accuracy of computed tomography (CT) for detecting cartilage involvement was as follows: sensitivity, 89 %; specificity, 80%. For detection of preepiglottic and paraglottic space invasion, MSCT has a sensitivity; 100% and 100 %, respectively, and a specificity; 55 % and 63%, respectively. Sensitivities and specifities of CT assessment for supraglottic mucosa, glottic mucosa and subglottic mucosa were 100 %, 100 % and 100 % respectively, 83 %, 85 % and 86 %, respectively. The high sensitivity value (100%) for the evaluation of the vocal cords may due to the images obtained during phonation. MSCT is a good, non-invasive imaging modality in staging of laryngeal cancer. The present study showed that CT was highly sensitive, but with relatively low specificity due to an increase in false positive values. The images obtained during phonation should be added to the neck CT protocol of the larynx cancer patients for improved evaluation of the glottic region, in particular. KEYWORDS: laryngeal cancer, staging, multislice computed tomography LARINGEAL KANSER: MULTIDEDEKTÖR BILGISAYARLI TOMOGRAFI ILE RADYOLOJIK EVRELEME VE PATOLOJIK KORELASYON ÖZET: Multidedektörlü bilgisayarlı tomografinin (MDBT) laringeal kanser evrelemesinde doğruluğunu değerlendirmek ve histopatolojik bulgularla kıyaslamak. Laringeal kanser tanısı alan ve cerrahi tedavi uygulanan 28 hasta radyolojik ve histopatolojik inceleme sonuçlarına göre evrelendi. Bilgisayarlı tomografinin (BT) kartilaj tutulumunu saptamada tanısal doğruluğunun sensitivitesi 89%; spesifitesi, 80%'dir. Preepiglottik ve paraglottik boşluk invazyonunun saptanmasında, MDBT'nin sırayla sensitivitesi 100%, 100%; spesitivitesi sırayla 55% ve 63% bulunmuştur. Supraglottik mukoza, glottik mukoza ve subglottik mukoza tutulumunun değerlendirilmesinde BT'nin sensitivite ve spesifite değerleri sırayla 100%,100% ve 100%, 83%,85% ve %86 idi. Vokal kordların değerlendirilmesindeki yüksek sensitivite değerleri 100%) fonasyon sırasında elde edilen imajlardan kaynaklanabilir. MDBT laringeal kanser evrelemesinde güvenilir ve non-invaziv bir görüntüleme metodudur. Çalışmamız gösterdi ki BT yüksek sensitivite değerlerine sahiptir. Ancak yalancı pozitif sonuçlardan dolayı nispeten düşük spesifite değerleri mevcuttur. Fonasyon sırasında elde olunan görüntüler, larinks kanserli hastalarda glottik bölgenin daha iyi değerlendirilmesi için boyun BT protokollerine eklenmelidir. ANAHTAR KELIMELER: laringeal kanser, evreleme, multiddektörlü bilgisayarlı tomografi 26 Laryngeal Cancer

show abstract

Section: Discussionsupporting

confidence: 45%

Section: Discussionmentioning

confidence: 99%

Laryngeal Cancer: Radiological Staging by Multislice Computed Tomography and Pathological Correlation

Atlanoğlu

Gürbüz

Açıkalın

et al. 2016

Osmangazi̇ Journal of Medicine

View full text Add to dashboard Cite

show abstract

“…Despite these differences in Se and Sp, there is no statistical significance between CAT and MRI in cartilage invasion assessment (175). In literature, the pretherapeutic staging accuracy of laryngeal carcinoma has been reported to be 86 and 87.5% with CAT and MRI, respectively (246); moreover, MRI is more sensitive than CAT and presents h a high negative predictive value for detection of neoplastic cartilage invasion (177,215).…”

mentioning

confidence: 99%

Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis.

Mannelli

Cecconi

Gallo

2016

Critical Reviews in Oncology/Hematology

View full text Add to dashboard Cite

Abstract.Background: Multi-step cancerogenesis guides laryngeal cancer onset and it includes a wide variety of pre-cancerous lesions that are macroscopically challenging to identify and distinguish from initial cancerous foci. Since the treatment of laryngeal cancer and its precursor lesions has a great impact on important laryngeal basic functions, early detection and preoperative assessment are important for a curative and function-preserving therapy. Nowadays, despite the high number of more advanced diagnostic techniques and methods, unfortunately, it is not uncommon for different clinicians to use different nomenclature or to identify different stage for the same laryngeal lesion. From these observations, it is obvious that an instrument offering the possibility to detect precancerous lesions, early cancerous lesions, and satellite foci or second primaries would be the key to improving management and outcome in laryngeal patients. Object. Different modalities of diagnostic techniques of laryngeal lesions exist. Rather than difference between benign and obvious malignant diseases, more difficult is to detect the presence of precancerous epithelial alterations. Not all tests achieve the same diagnostic accuracy, hence this meta-analysis of literature aimed to synthesize the validity of each single diagnostic technique in identifying and staging laryngeal disease. Methods: A systematic review of literature was led searching for articles mentioning the following terms including their various combinations to maximize the yield: larynx, laryngeal precancerous lesions, laryngeal cancer, white light (WL) endoscopy, stroboscopy, contact endoscopy (CE), autofluorescence (AF), ultrasound (US), narrow band imaging (NBI), computed axial tomography (CAT), magnetic resonance imaging (MRI), positron emission tomography (PET), CAT/PET. Then, a quantitative analysis was carried on for paper published after 2005 onward, reporting a minumun series of 10 patients each study, declaring sensitivity and specificity of each diagnostic system. Results: The search identified 7215 publications, of which 3616 published after 2005, with a final results of a total of 214 articles stratified and included by our selection criteria. 42 out of 214 articles were selected for quantitative synthesis. 25 out of 41 studies had a quality score of ≥ 6 (good), 16 presented a score between 4 and 5 (fair). While objections can be raised about the pooling of different diagnostic procedures under the same group and the high level of heterogeneity in the meta-analyses, the inclusion of over 4400 laryngeal lesions makes the results fairly robust. Conclusions: A comprehensive overview of the most recent advances in laryngeal imaging technology combined with all of the information needed to interpret findings and successfully manage patients with voice disorders can be found herein. With these data, clinicians can riskstratify patients and select proper examination modalities in order to provide appropriate care. Moreover, study limitations, together with p...

show abstract

“…These are the areas in which cross-sectional imaging plays a major role in identifying the tumor spread, which may not be readily accessed by laryngoscope or mirror examinations. [13][14][15] Coronal and sagittal reformatted images provide an accurate and reliable assessment of craniocaudal extension of disease, which is often limited by the axial image acquisition only, even with additional maneuvers. In the era of isovoxel multidetector CT technology, the staging of laryngeal cancer should be performed with contrastenhanced neck CT with thin-section coronal and sagittal reformation.…”

Section: Discussionmentioning

confidence: 99%

Staging of Laryngeal Cancer Using 64-Channel Multidetector Row CT: Comparison of Standard Neck CT with Dedicated Breath-Maneuver Laryngeal CT

Gilbert¹,

Dalley²,

Maronian³

et al. 2009

AJNR Am J Neuroradiol

View full text Add to dashboard Cite

BACKGROUND AND PURPOSE:With a 64-channel multidetector row CT, imaging acquisition during speech, swallowing, or phonation has become feasible. However, the actual benefit of these additional focused images should be critically evaluated with respect to radiation dose. The purpose of this study was to determine if dedicated laryngeal CT using breath-holding and straw-blowing improved the accuracy of TNM-staging for patients with biopsy-proved laryngeal carcinomas in comparison with a standard neck CT.

show abstract

Invasion of laryngeal cartilage by cancer: comparison of CT and MR imaging.

Cited by 108 publications

References 0 publications

Laryngeal Cancer: Radiological Staging by Multislice Computed Tomography and Pathological Correlation

Laryngeal Cancer: Radiological Staging by Multislice Computed Tomography and Pathological Correlation

Laryngeal preneoplastic lesions and cancer: challenging diagnosis. Qualitative literature review and meta-analysis.

Staging of Laryngeal Cancer Using 64-Channel Multidetector Row CT: Comparison of Standard Neck CT with Dedicated Breath-Maneuver Laryngeal CT

Contact Info

Product

Resources

About