Invasive Acremonium Strictum Infection in a Bone Marrow Transplant Recipient

Miyakis, Spiros; Velegraki, Aristea; Delikou, Sophia; Parcharidou, Agapi; Papadakis, Vassilios; Kitra, Vasiliki; Papadatos, Ioannis; Polychronopoulou, Sophia

doi:10.1097/01.inf.0000202107.73095.ad

Cited by 40 publications

(22 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Normalized ratios for LA-screen and LA-confirm coagulation times (ratios a/c ) were calculated and samples were deemed positive for lupus anticoagulant when the ratios a/c was 1Á15 or higher, on the basis of the 99th percentile of the value recorded for 40 healthy volunteers. This measurement is in accordance with current recommendations for testing lupus anticoagulant (Miyakis et al, 2006). IgG anti-b2-glycoprotein 1 antibodies were measured as described previously and reported as percentage of a positive control (Urbanus et al, 2009).…”

Section: Data Collectionmentioning

confidence: 99%

Pregnancy loss and risk of ischaemic stroke and myocardial infarction

et al. 2016

View full text Add to dashboard Cite

We investigated whether pregnancy loss increases the risk of arterial thrombosis in young women. Women (age 18-50 years) with ischaemic stroke (IS) or myocardial infarction (MI) and at least one pregnancy were compared for pregnancy loss in a control group. Odds ratios (OR) with 95% confidence intervals (CI), adjusted for matching variables, cardiovascular risk factors, cardiovascular family history and the presence of antiphospholipid antibodies, were calculated for the number of pregnancy losses as well as the type of unsuccessful pregnancy (early miscarriage, late miscarriage and stillbirth). 165 IS cases, 218 MI cases and 743 controls were included. Women with multiple (≥3) pregnancy loss had a doubled risk of arterial thrombosis (OR 2·37, 95%CI 0·99-5·70) compared with women without pregnancy loss, similarly to women who experienced stillbirth (OR 1·68, 95%CI 0·79-3·55). Both relative risks were higher for IS (OR 3·51, 95%CI 1·08-11·35 and 2·06, 95%CI 0·81-5·23, respectively) than for MI (OR 2·04, 95%CI 0·71-5·86 and 1·04, 95%CI 0·39-2·79). Adjustment for antiphospholipid antibodies did not affect the estimates. Multiple pregnancy loss and stillbirth increases the risk of IS and, to a lesser extent, of MI, even when other cardiovascular risk factors and antiphospholipid antibodies are accounted for.

show abstract

Section: Data Collectionmentioning

confidence: 99%

Pregnancy loss and risk of ischaemic stroke and myocardial infarction

et al. 2016

View full text Add to dashboard Cite

show abstract

“…Acremonium falciforme is nowadays Fusarium falciforme, a member of the Fusarium solani species complex. Members of this genus are recognized as aetiological agents of nail and corneal infections, mycetoma, peritonitis and dialysis fistula infection, osteomyelitis, meningitis following spinal anaesthesia in a healthy person, cerebritis in an intravenous drug abuser, endocarditis in a prosthetic valve operation, and a pulmonary infection in a child [147,[149][150][151][152][153][154]. Occasionally, deep Acremonium infections have been reported in patients with serious underlying diseases [8].…”

Section: Acremonium Infectionsmentioning

confidence: 99%

ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp., Scedosporium spp. and others

Tortorano

Richardson

Roilides³

et al. 2014

Clinical Microbiology and Infection

426

401

View full text Add to dashboard Cite

Mycoses summarized in the hyalohyphomycosis group are heterogeneous, defined by the presence of hyaline (non-dematiaceous) hyphae. The number of organisms implicated in hyalohyphomycosis is increasing and the most clinically important species belong to the genera Fusarium, Scedosporium, Acremonium, Scopulariopsis, Purpureocillium and Paecilomyces. Severely immunocompromised patients are particularly vulnerable to infection, and clinical manifestations range from colonization to chronic localized lesions to acute invasive and/or disseminated diseases. Diagnosis usually requires isolation and identification of the infecting pathogen. A poor prognosis is associated with fusariosis and early therapy of localized disease is important to prevent progression to a more aggressive or disseminated infection. Therapy should include voriconazole and surgical debridement where possible or posaconazole as salvage treatment. Voriconazole represents the first-line treatment of infections due to members of the genus Scedosporium. For Acremonium spp., Scopulariopsis spp., Purpureocillium spp. and Paecilomyces spp. the optimal antifungal treatment has not been established. Management usually consists of surgery and antifungal treatment, depending on the clinical presentation.

show abstract

“…At least 35 Acremonium infections in adults have been described in the literature [87]. Fifteen cases of documented Acremonium infection (excluding mycetoma and keratitis) in children have been reported [93]. In the recent reports, in both children and adults, Acremonium strictum is the most commonly identified species.…”

mentioning

confidence: 99%

Changing epidemiology of systemic fungal infections

Richardson

Lass‐Flörl

2008

Clinical Microbiology and Infection

443

258

View full text Add to dashboard Cite

Species of Candida and Aspergillus remain the most common causes of invasive fungal infections, but other yeasts and filamentous fungi are emerging as significant pathogens. Opportunistic yeast-like fungi and moulds such as Zygomycetes, Fusarium spp. and Scedosporium spp. are increasingly being recognised in patient groups such as those with leukaemia and in bone marrow transplant recipients. Recognition of these epidemiological changes is critical to patient care. The key elements in selecting an appropriate antifungal agent are the type of patient (solid-organ or stem-cell transplant), severity of immunosuppression, history of prolonged exposure to antifungal drugs, and knowledge of the genera and species of the infecting pathogen and its typical susceptibility pattern.

show abstract

Invasive Acremonium Strictum Infection in a Bone Marrow Transplant Recipient

Cited by 40 publications

References 18 publications

Pregnancy loss and risk of ischaemic stroke and myocardial infarction

Pregnancy loss and risk of ischaemic stroke and myocardial infarction

ESCMID and ECMM joint guidelines on diagnosis and management of hyalohyphomycosis: Fusarium spp., Scedosporium spp. and others

Changing epidemiology of systemic fungal infections

Contact Info

Product

Resources

About