1992
DOI: 10.1093/clinids/14.1.66
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Invasive Aspergillosis in Patients with AIDS

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Cited by 143 publications
(68 citation statements)
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“…Risk factors for invasive aspergillosis are prolonged neutropenia and\or long-term administration of high dose corticosteroids (Denning, 1998). The frequency of invasive aspergillosis has increased 14-fold in the past decade (Groll et al, 1996), mainly due to the greater numbers of bone marrow and organ transplant recipients (Wald et al, 1997), more aggressive cytotoxic chemotherapy used to treat cancer patients (Bodey et al, 1992) and the emergence of the human immunodeficiency syndrome (HIV-AIDS) (Minamoto et al, 1992). There are currently only two antifungal agents used to treat the disease, amphotericin B and itraconazole, and their success rate is only 34 %, even when used prophylactically (Denning, 1998).…”
mentioning
confidence: 99%
“…Risk factors for invasive aspergillosis are prolonged neutropenia and\or long-term administration of high dose corticosteroids (Denning, 1998). The frequency of invasive aspergillosis has increased 14-fold in the past decade (Groll et al, 1996), mainly due to the greater numbers of bone marrow and organ transplant recipients (Wald et al, 1997), more aggressive cytotoxic chemotherapy used to treat cancer patients (Bodey et al, 1992) and the emergence of the human immunodeficiency syndrome (HIV-AIDS) (Minamoto et al, 1992). There are currently only two antifungal agents used to treat the disease, amphotericin B and itraconazole, and their success rate is only 34 %, even when used prophylactically (Denning, 1998).…”
mentioning
confidence: 99%
“…Minamotoet al discussed invasive aspergillosis in patients with AIDS, describing the possible risk factors associated with aspergillosis such as leukopenia, use of corticosteroids, and antineoplastic agents (19). In the present case the use of dexamethasone may have aggravated the condition of Aspergillus infection.…”
Section: Discussionmentioning
confidence: 66%
“…1,5 Other possible explanations for infection in patients with HIV disease include the increasing use of corticosteroid treatment, as is used in the treatment of Pneumocystis carinii pneumonia 1,6,7 ; neutropenia-inducing antiretroviral drugs such as zidovudine 1,6 ; and a prolonged life of patients with late-stage HIV disease. 1,6,7 We find 3 interesting features of this case. First, direct spinal invasion by pulmonary aspergillosis, though rare, is not unheard of, as several cases of chest wall invasion with epidural aspergillosis have been documented in the past.…”
Section: Discussionmentioning
confidence: 99%