Invasive breast cancer with Paget’s disease: A rare case report from a tertiary facility in Northern Tanzania

Lodhia, Jay; Urassa, Ellyagape; Mremi, Alex

doi:10.1177/2050313x231151753

Cited by 2 publications

(1 citation statement)

References 13 publications

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“…It was initially described by John of Arderne in 1307 [3] and by Velpeau later in 1856 as erythematous-eczematous changes in the NAC [4,5], but it was James Paget, two decades later, who reported a relationship between a nipple rash and mammary gland tumor that gave the name to the disease [6]. Although patients with a palpable mass and/or suspicious digital mammography (DM) and ultrasound (US) findings have a high probability of invasive cancer and worse outcomes [7], even in patients without radiological abnormalities but with clinical symptoms, there is the possibility of a pathology that may need treatment.…”

Section: Introduction and Historical Pillsmentioning

confidence: 99%

A Pictorial Exploration of Mammary Paget Disease: Insights and Perspectives

Mariano,

Nicosia,

Pupo

et al. 2023

Cancers

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Mammary Paget disease (MPD) is a rare condition primarily affecting adult women, characterized by unilateral skin changes in the nipple–areolar complex (NAC) and frequently associated with underlying breast carcinoma. Histologically, MPD is identified by large intraepidermal epithelial cells (Paget cells) with distinct characteristics. Immunohistochemical profiles aid in distinguishing MPD from other skin conditions. Clinical evaluation and imaging techniques, including magnetic resonance imaging (MRI), are recommended if MPD is suspected, although definitive diagnosis always requires histological examination. This review delves into the historical context, epidemiology, pathogenesis, clinical manifestations, and diagnosis of MPD, emphasizing the need for early detection. The classification of MPD based on pathogenesis is explored, shedding light on its varied presentations. Treatment options, including mastectomy and breast-conserving surgery, are discussed with clear guidelines for different scenarios. Adjuvant therapies are considered, particularly in cases with underlying breast cancer. Prognostic factors are outlined, underlining the importance of early intervention. Looking to the future, emerging techniques, like liquid biopsy, new immunohistochemical and molecular markers, and artificial intelligence-based image analysis, hold the potential to transform MPD diagnosis and treatment. These innovations offer hope for early detection and improved patient care, though validation through large-scale clinical trials is needed.

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Section: Introduction and Historical Pillsmentioning

confidence: 99%

A Pictorial Exploration of Mammary Paget Disease: Insights and Perspectives

Mariano,

Nicosia,

Pupo

et al. 2023

Cancers

View full text Add to dashboard Cite

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Paget’s disease of nipple with synchronous contralateral invasive ductal carcinoma in a 36-year-old female: An isolated or genetic coexistence !

Raj,

Halder,

Mallik

et al. 2024

Preprint

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Mammary Paget’s disease (MPD) is a rare eczematoid lesion of nipple and adjacent areola. It was first described by Sir James Paget, a pathologist and surgeon, in 1874. Similar disease process may also involve external genitals, perineum, perianal region of both sexes and termed as extra mammary Paget’s disease. Early clinical recognition is difficult as it mimics other inflammatory breast lesions. Definitive diagnosis by histopathological examination is necessary to rule out any underlying invasive breast cancer at the same time. Management varies from wide local excision, lumpectomy, mastectomy or modified radical mastectomy followed by reconstruction depending on the extent of lesion and invasiveness. Evidence of invasive breast carcinoma in ipsilateral breast is rare and in contralateral breast is rarest in literatures worldwide. Here, we are presenting one such rare case of a 36year old lady with a history of eczematous lesion in right nipple with invasive ductal carcinoma in left breast along with its management and literature review.

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Invasive breast cancer with Paget’s disease: A rare case report from a tertiary facility in Northern Tanzania

Cited by 2 publications

References 13 publications

A Pictorial Exploration of Mammary Paget Disease: Insights and Perspectives

A Pictorial Exploration of Mammary Paget Disease: Insights and Perspectives

Paget’s disease of nipple with synchronous contralateral invasive ductal carcinoma in a 36-year-old female: An isolated or genetic coexistence !

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