Invasive breast carcinoma: Analysis of dynamic magnetic resonance imaging enhancement features and cell proliferative activity determined by DNA S‐phase percentage

Stomper, Paul C.; Herman, Steven D.; Klippenstein, Donald; Winston, Janet S.; Budnick, Rose Marie; Stewart, Carleton C.

doi:10.1002/(sici)1097-0142(19960501)77:9<1844::aid-cncr13>3.0.co;2-#

Cited by 20 publications

(3 citation statements)

References 21 publications

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“…Even so, our data suggest a value for the dynamic MRI in assessing the metastatic potential of breast carcinomas. In contrast, there was a significant and positive association between the rate of mitotic index and the peak of maximum intensity before two minutes, which is in accordance with previous studies reporting a positive association between MRI parameters and other proliferative parameters, such as high DNA S-phase percentage [28] or proliferative cellular activity as shown by proliferative nuclear antigen (PCNA) immunoreactivity [22]. Therefore our data appears to indicate that the proliferative activity and the invasive potential of cancerous cells could be, at least partially, unrelated processes.…”

Section: Discussionsupporting

confidence: 91%

Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico-pathological and biological factors in invasive breast cancer

et al. 2010

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BackgroundTo investigate the relationship between the magnetic resonance imaging (MRI) features of breast cancer and its clinicopathological and biological factors.MethodsDynamic MRI parameters of 68 invasive breast carcinomas were investigated. We also analyzed microvessel density (MVD), estrogen and progesterone receptor status, and expression of p53, HER2, ki67, VEGFR-1 and 2.ResultsHomogeneous enhancement was significantly associated with smaller tumor size (T1: < 2 cm) (p = 0.015). Tumors with irregular or spiculated margins had a significantly higher MVD than tumors with smooth margins (p = 0.038). Tumors showing a maximum enhancement peak at two minutes, or longer, after injecting the contrast, had a significantly higher MVD count than those which reached this point sooner (p = 0.012). The percentage of tumors with vascular invasion or high mitotic index was significantly higher among those showing a low percentage (≤ 150%) of maximum enhancement before two minutes than among those ones showing a high percentage (>150%) of enhancement rate (p = 0.016 and p = 0.03, respectively). However, there was a significant and positive association between the mitotic index and the peak of maximum intensity (p = 0.036). Peritumor inflammation was significantly associated with washout curve type III (p = 0.042).ConclusionsVariations in the early phase of dynamic MRI seem to be associated with parameters indicatives of tumor aggressiveness in breast cancer.

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Section: Discussionsupporting

confidence: 91%

Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico-pathological and biological factors in invasive breast cancer

et al. 2010

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“…It was also reported to be associated with high angiogenesis in the tumor periphery [23,24], but central tumor necrosis also accounted for this feature and may even be more important than MVD [45]. One study [46] showed a correlation between rim enhancement and high DNA S-phase percentage and suggested that rim enhancement is more often seen among rapidly growing cancers. Our results confirm that peripheral rim-like enhancement is not only a useful criterion for obtaining correct diagnosis, but is associated with the proliferative activity of the tumors.…”

Section: Mr Enhancement Morphologymentioning

confidence: 99%

Invasive breast cancer: correlation of dynamic MR features with prognostic factors

et al. 2003

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The purpose of this exploratory study was to correlate kinetic and morphologic MR features with histologic prognostic factors in invasive breast cancer. Sixty-one women with invasive breast cancer underwent dynamic contrast-enhanced MR imaging at 1.5 T, using T1-weighted 3D fast low-angle shot technique. The MR characteristics were correlated with classical pathologic prognostic factors (tumor size, histologic type, grade and lymph node status) and immunohistochemically detected biomarkers [c-erbB-2, p53, Ki-67, and estrogen receptor (ER)]. Univariate and multivariate statistical analyses were performed. Presence of rim enhancement pattern, early maximal enhancement and washout phenomenon were independently associated with established predictors of poor prognosis (higher histologic grade, positive Ki-67, and negative ER status). Our results suggest that these MR signs are not only important in differentiating benign from malignant lesions, but may also be useful to noninvasively identify highly aggressive breast carcinomas.

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“…New radiological modalities such as MRI and 99m Tc-sestamibi scintigraphy are under evaluation for the assessment and analysis of prognostic factors [11,19,20].…”

Section: Discussionmentioning

confidence: 99%

99mTc-sestamibi uptake and histological malignancy grade in invasive breast carcinoma

Danielsson

Sánchez-Crespo

Pegerfalk

et al. 2003

Eur J Nucl Med Mol Imaging

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The aim of this study was to investigate whether there is a correlation between (99m)Tc-sestamibi uptake and histological malignancy grade in breast carcinoma. Such a correlation could, prior to surgery and histopathological analysis, facilitate selection of patients who need adjuvant therapy. Ninety-six patients with mammographically determined lesions and/or a palpable tumour suspected for malignancy underwent (99m)Tc-sestamibi scintimammography prior to surgery. The final diagnosis was determined by histopathological examination. Benign lesions, cancer in situ and tumours located medially in the breast were excluded. Fifty-three invasive cancer lesions in 53 patients were finally included in the study. Planar scintigraphic breast imaging included two prone lateral projections and one anterior supine projection taken 10 min after injection of 700 MBq (99m)Tc-sestamibi. Focal (99m)Tc-sestamibi uptake in breast lesions was used as the scintigraphic criterion of abnormality. Tumour to background ratios were calculated with partial volume compensation, and histological malignancy grading was performed according to the Elston classification. A correlation was found between (99m)Tc-sestamibi uptake and histological malignancy grade in invasive breast carcinomas ( P

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Invasive breast carcinoma: Analysis of dynamic magnetic resonance imaging enhancement features and cell proliferative activity determined by DNA S‐phase percentage

Abstract: Increased cell proliferation in invasive breast carcinoma, as determined by high DNA S-phase percentage, is significantly associated with a peripheral MRI enhancement pattern but unrelated to greater MRI enhancement amplitude, rate, or washout.

Cited by 20 publications

References 21 publications

Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico-pathological and biological factors in invasive breast cancer

Relationship between morphological features and kinetic patterns of enhancement of the dynamic breast magnetic resonance imaging and clinico-pathological and biological factors in invasive breast cancer

Invasive breast cancer: correlation of dynamic MR features with prognostic factors

99mTc-sestamibi uptake and histological malignancy grade in invasive breast carcinoma

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