Invasive Candida auris infections in Kuwait hospitals: epidemiology, antifungal treatment and outcome

Khan, Ziauddin; Ahmad, Suhail; Benwan, Khalifa Al; Purohit, Prashant; Al‐Obaid, Inaam; Bafna, Ritu; Emara, Maha; Mokaddas, Eiman; Abdullah, Aneesa; Alobaid, Khaled; Joseph, Leena

doi:10.1007/s15010-018-1164-y

Cited by 53 publications

(44 citation statements)

References 41 publications

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“…Present results concur with a study in Kuwait reported multidrug resistance and high mortality rate among cases of C. auris infections (29). Also, two studies in Oman reported of C.…”

Section: Resultssupporting

confidence: 92%

Emergence of multi-drug resistance Candida auris in Saudi Arabia

Aljindan¹,

AlEraky²,

Mahmoud³

et al. 2020

Preprint

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Background: Candida auris is an emerging multi-drug resistant pathogen with high mortality rate, several cases and nosocomial infections have been reported worldwide causing a major challenge for clinicians and microbiological laboratories. Objectives: The study aim to, describe new cases of C. auris from different sites of infection confirmed by MALDI TOF MS and ribosomal sequencing, develop the phylogenetic analysis of these isolates, detect resistant strains of C. auris to both azole and echinocandin by amplification of ERG11 and FKS1 genes. Methods: A total of six specimens were collected from blood, urine, ear swab and groin screening sample during the period from November 2018 to March 2019. Isolates were incubated for 48 hours on Sabroud agar at 42℃, then confirmed by Matrix-Assisted Laser Desorption/Ionization-Time of Flight mass spectrometry (MALDI-TOF MS). Sequences of 18S rRNA gene from isolates and phylogenetic analysis were performed. Finally, molecular analysis of resistance genes was performed to detect the efficacy of treatment. Results: Clinical isolates were identified by the growth on Sabroud agar at 42℃ and confirmed by MALDI-TOF MS analysis. Evolutionary analyses were conducted in MEGA7 and sequences of 18S rRNA gene were submitted to GenBank. All samples were positive for both ERG11 and FKS1 which confer azole- and echinocandin-resistant strains. Conclusions: This study shed light on a public health threat of an emerging pathogen. Therefore, the hospital implemented strict contact screening and infection control precautions to prevent C. auris infection. Finally, there is a critical need to monitor the antifungal resistance in different geographical areas and implementation of efficient guidelines for treatment.

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“…Present results concur with a study in Kuwait reported multidrug resistance and high mortality rate among cases of C. auris infections (29). Also, two studies in Oman reported of C.…”

Section: Resultssupporting

confidence: 92%

Emergence of multi-drug resistance Candida auris in Saudi Arabia

Aljindan¹,

AlEraky²,

Mahmoud³

et al. 2020

Preprint

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“…The number of patients affected is probably underestimated due to difficulties with identification of C. auris because of the lack of proper laboratory support. We report the first case of C. auris in Iran which adds up now to a total of five countries around the Persian Gulf, that is Kuwait, Oman, United Arab Emirates and Saudi Arabia . Choi et al reviewed reported cases of C. auris from otitis externa from 2009 to the end of 2016.…”

Section: Discussionmentioning

confidence: 94%

“…Candida auris is an emerging serious public health threat with high mortality and morbidity that can range from mild superficial infections to fungemia . Since the first case of C. auris in 2009, numerous cases and several outbreaks have been reported from all continents . The global increase in reports of C. auris , transmission in healthcare facilities, frequent relapse and treatment failures qualifies C. auris as one of the top‐ten most serious fungal pathogens .…”

Section: Introductionmentioning

confidence: 99%

Candida auris otomycosis in Iran and review of recent literature

Abastabar

Haghani

Ahangarkani

et al. 2019

Mycoses

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Summary Candida auris is a multidrug‐resistant yeast emerging in immunocompromised and in otherwise healthy individuals. Due to difficulties in microbiological identification of C. auris because of the lack of available laboratory technology in developing countries, the number of patients affected is most likely underestimated. We report the first case of C. auris otitis which now adds Iran as the fifth country around the Persian Gulf, in addition to Kuwait, Oman, United Arab Emirates and Saudi Arabia. Candida auris is an unknown pathogen in routine laboratories in Iran because most Candida isolates are probably misdiagnosed. Otomycosis seems to be a different clinical presentation of C. auris mainly involving isolates from the East‐Asian clade. We compared the mycological and clinical details of the Iranian patient with other cases of otitis reported since the last review of C. auris otomycosis in 2017.

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“…127 Epidemiology and transmission C auris has been associated with multiple nosocomial outbreaks, especially in the intensive care setting. [139][140][141][142][143][144] An evaluation of C auris in New York City health care facilities demonstrated epidemiologic links between cases in multiple hospitals and long-term care facilities. 138 Importantly, colonization with C auris has been detected at multiple body sites including nares, groin, axilla, and rectum.…”

Section: Aurismentioning

confidence: 99%