Invasive Candidiasis in Hospitalized Patients with Major Burns

Lin, Yi-Ling; Chen, I-Chen; Yen, Jung-Hsing; Lai, Chih-Sheng; Tsai, Yueh-Chi; Lu, Chun-Te; Wu, Cheng-Yeu; Lin, Wei-Szu; Lin, Ching-Heng; Huang, Yung-Chieh

doi:10.3390/jpm12010047

Cited by 3 publications

(2 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…. These infections are one of the most common nosocomial infections associated with high mortality in hospitalized patients due to their difficult diagnosis and treatment [1,2,[5][6][7]19] . If patients develop candidaemia, some of their clinical and laboratory symptoms may change [20,21] .…”

Section: Resultsmentioning

confidence: 99%

Automated Blood Cell Counting in Candidaemia: A Comparative Study of Sysmex-X Series 500 and KX-21 Counters

Tarkhan,

Aaliehpour,

Sepahvand

2023

IEM

View full text Add to dashboard Cite

Background: Hidden fungal infections may lead to errors in blood cell counts and inappropriate treatment selection with serious consequences in many patients. This study aimed to evaluate the results of two automated blood cell counters Sysmex-X 500 and KX-21 in samples containing Candida albicans and Candida glabrata. Materials & Methods:In this study, 144 blood samples of O-blood type were examined in the presence and absence of C. glabrata and C. albicans fungi at different concentrations by two automated blood cell counters Sysmex-X 500 and KX-21 in Lorestan University of Medical Sciences in 2017. Fungal samples were prepared at a concentration of 0.5 McFarland, equally added to the blood samples, and read by Sysmex-X 500 and KX-21. Findings:The average number of erythrocytes, leukocytes, and platelets read by Sysmex-X 500 and KX-21 devices increased in the presence of both fungal samples compared to the primary samples. In addition, the number of lymphocytes, neutrophils, and monocytes read by Sysmex-X 500 and KX-21 devices in the presence of fungal samples was significantly higher compared to the primary samples (p< .05). The increase in mean blood cell counts in the presence of both fungal samples was significantly higher in X 500 than in . Conclusion:This study results showed that among these two devices, the Sysmex-X Series 500 device showed less variation compared to the actual values of blood cells. The use of this device seems to reduce measurement error in blood cell counting.

show abstract

Section: Resultsmentioning

confidence: 99%

Automated Blood Cell Counting in Candidaemia: A Comparative Study of Sysmex-X Series 500 and KX-21 Counters

Tarkhan,

Aaliehpour,

Sepahvand

2023

IEM

View full text Add to dashboard Cite

show abstract

“…Risk factors for invasive Candida infections relate to a wide variety of conditions (hematologic and solid organ malignancies, burns, major surgery) and treatment methods (stem cell and organ transplantation, use of immunosuppressive agents, antibiotics, chemotherapy, hemodialysis, intravenous nutrition) [ 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ]. Prolonged hospital stay and admission to intensive care units are also recognized as major risk factors for invasive candidiasis [ 23 , 24 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

Diagnosis and Treatment of Invasive Candidiasis

Barantsevich

2022

Antibiotics

View full text Add to dashboard Cite

Candida species, belonging to commensal microbial communities in humans, cause opportunistic infections in individuals with impaired immunity. Pathogens encountered in more than 90% cases of invasive candidiasis include C. albicans, C. glabrata, C. krusei, C. tropicalis, and C. parapsilosis. The most frequently diagnosed invasive infection is candidemia. About 50% of candidemia cases result in deep-seated infection due to hematogenous spread. The sensitivity of blood cultures in autopsy-proven invasive candidiasis ranges from 21% to 71%. Non-cultural methods (beta-D-glucan, T2Candida assays), especially beta-D-glucan in combination with procalcitonin, appear promising in the exclusion of invasive candidiasis with high sensitivity (98%) and negative predictive value (95%). There is currently a clear deficiency in approved sensitive and precise diagnostic techniques. Omics technologies seem promising, though require further development and study. Therapeutic options for invasive candidiasis are generally limited to four classes of systemic antifungals (polyenes, antimetabolite 5-fluorocytosine, azoles, echinocandins) with the two latter being highly effective and well-tolerated and hence the most widely used. Principles and methods of treatment are discussed in this review. The emergence of pan-drug-resistant C. auris strains indicates an insufficient choice of available medications. Further surveillance, alongside the development of diagnostic and therapeutic methods, is essential.

show abstract

Multi‐state evaluation of Candida infections in burn patients

Salimi,

Javidnia,

Abastabar

et al. 2024

Mycoses

View full text Add to dashboard Cite

BackgroundBurn patients are at high risk of developing secondary invasive fungal infections due to their compromised skin barrier, extensive use of antibiotics, and immunosuppression.ObjectivesWe investigated demographic characteristics and clinical factors associated with Candida infections in intensive care unit (ICU) burn patients, and the in vitro antifungal susceptibility of species of isolates.MethodsA total of 353 burn patients admitted to three major ICUs of burn centers in Iran were evaluated between 2021 and 2023. Patients were considered as colonisation and candidemia. Demographic characteristics, burn‐related factors, and clinical conditions were compared among the groups. Furthermore, we identified fungi at the species level and performed antifungal susceptibility testing according to CLSI guidelines.ResultsOverall, 46.2% of patients were colonised with a Candida species, leading to candidemia in 15.3%. The most frequently isolated species from candidemia and burn wound colonisation were Candida parapsilosis (37.0%) and Candida albicans (31.9%), respectively. Risk factors linked to candidemia included larger total body surface area (TBSA) (>50%), older patients, indwelling catheters, diabetes, and an extended ICU stay. Mortality rate was higher among candidemia patients (82.5%) compared to colonised patients (7.3%). The resistance rate of the strains isolated from candidemia to fluconazole and voriconazole was 28% and 18.2%, respectively.ConclusionWe found that a higher percentage of TBSA burn injuries, longer hospital stays, and catheterization are important predictors of candidemia. The mortality rate was significantly higher in people infected with non‐albicans Candida species. Prevention and treatment strategies for candidemia should be based on updated, regional epidemiological data.

show abstract

Invasive Candidiasis in Hospitalized Patients with Major Burns

Cited by 3 publications

References 24 publications

Automated Blood Cell Counting in Candidaemia: A Comparative Study of Sysmex-X Series 500 and KX-21 Counters

Automated Blood Cell Counting in Candidaemia: A Comparative Study of Sysmex-X Series 500 and KX-21 Counters

Diagnosis and Treatment of Invasive Candidiasis

Multi‐state evaluation of Candida infections in burn patients

Contact Info

Product

Resources

About