Invasive Candidiasis in Patients with Implants

Shoham, Shmuel

doi:10.1007/s12281-010-0040-8

Cited by 3 publications

(2 citation statements)

References 53 publications

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“…Other cases of asymptomatic candidemia and cases of candidemia related to prostheses have been described before. How an otherwise healthy woman suffered such a severe infection usually related to polymorbid or immunosuppressed people remains a mystery [ 12 , 13 ].…”

Section: Discussionmentioning

confidence: 99%

Rare Pseudotumor in Ceramic-On-Ceramic Total Hip Replacement with Concomitant Fungal Periprosthetic Joint Infection: A Case Report

Marcomini,

Iqbal,

Bennett

2023

Am J Case Rep

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Patient: Female, 67-year-old Final Diagnosis: Infection Symptoms: Swelling • unprovoked DVT Clinical Procedure: — Specialty: Orthopedics and Traumatology Objective: Rare disease Background: Total hip replacement (THR) is a commonly performed treatment for severe osteoarthritis. In this report, we present the case of a woman who unfortunately suffered 2 severe but rare complications of THRs: a pseudo-tumor formation on a Delta ceramic-on-ceramic bearing and a fungal periprosthetic joint infection (PJI). Case Report: In early 2016, a 63-year-old woman underwent an elective left total hip replacement with ceramic-on-ceramic bearing due to severe osteoarthritis. In 2021, she suffered 2 unprovoked DVTs. Therefore, ultrasound (US) Doppler imaging of the left lower limb was performed, which showed a mass close to the iliac vein. After magnetic resonance imaging (MRI) to further examine the mass, a pseudotumor was confirmed. Revision surgery was performed, after which positive swabs for fungal infection were identified, but were not clinically correlated. A few years before, a deep buccal fungal infection was suspected and treated, but never confirmed. The pseudotumor was confirmed by histology samples. A few weeks later, the patient presented again with symptoms of infection, and 2 debridement, antibiotics, and implant retention (DAIR) procedures were performed, in which further positive swabs of Candida parapsilosis were obtained. Currently, the patient is on conservative therapy with long-term antifungal medication since she refused a staged procedure due to personal circumstances. Conclusions: In conclusion, this case report documents the first ever reported pseudotumor associated with a ceramic-on-ceramic bearing THR with concomitant fungal PJI. Although it is unlikely for a person to develop 2 rare complications without them being connected, no causal link could be established.

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Section: Discussionmentioning

confidence: 99%

Rare Pseudotumor in Ceramic-On-Ceramic Total Hip Replacement with Concomitant Fungal Periprosthetic Joint Infection: A Case Report

Marcomini,

Iqbal,

Bennett

2023

Am J Case Rep

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“…Candida infection on implantable medical devices is associated with very high mortality rates ( 73 – 75 ). Unfortunately, it is only rarely cured on site and in most cases require surgical removal ( 74 ).…”

Section: Discussionmentioning

confidence: 99%

Thrombin-Derived C-Terminal Peptide Reduces Candida -Induced Inflammation and Infection In Vitro and In Vivo

Dahlman

Puthia

Petrlová

et al. 2021

Antimicrob Agents Chemother

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Infections due to the opportunistic fungus Candida have been on the rise in the last decades, especially in immunocompromised individuals and hospital settings. Unfortunately, the treatments available today are limited. Thrombin-derived C-terminal peptide (TCP-25) is an antimicrobial peptide (AMP) with antibacterial and immunomodulatory effects. In this work, we, for the first time, demonstrate TCP-25’s ability to counteract Candida in vitro and in vivo . Using a combination of viable count assay, radial diffusion assay, fluorescence and transmission electron microscopy analyses, TCP-25 was found to exert a direct fungicidal activity. An inhibitory activity of TCP-25 on NF-κB activation induced by both zymosan alone and heat-killed C. albicans was demonstrated in vitro using THP-1 cells, and in vivo using NF-κB reporter mice. Moreover, the immunomodulatory property of TCP-25 was further substantiated in vitro by analyzing cytokine responses in human blood stimulated with zymosan, and in vivo employing a zymosan-induced peritonitis model in C57BL/6 mice. The therapeutic potential of TCP-25 was demonstrated in mice infected with luminescent C. albicans . Finally, the binding between TCP-25 and zymosan was investigated using circular dichroism spectroscopy and intrinsic fluorescence analysis. Taken together, our results show that TCP-25 has a dual function by inhibiting Candida as well as the associated zymosan-induced inflammation. The latter function is accompanied by a change in secondary structure upon binding to zymosan. TCP-25, therefore, shows promise as a novel drug candidate against Candida infections.

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Fungal Attachment-Resistant Polymers for the Additive Manufacture of Medical Devices

Yong,

Sefton,

Vallières

et al. 2024

ACS Appl. Mater. Interfaces

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This study reports the development of the first copolymer material that (i) is resistant to fungal attachment and hence biofilm formation, (ii) operates via a nonkilling mechanism, i.e., avoids the use of antifungal actives and the emergence of fungal resistance, (iii) exhibits sufficient elasticity for use in flexible medical devices, and (iv) is suitable for 3D printing (3DP), enabling the production of safer, personalized medical devices. Candida albicans (C. albicans) can form biofilms on in-dwelling medical devices, leading to potentially fatal fungal infections in the human host. Poly(dimethylsiloxane) (PDMS) is a common material used for the manufacture of medical devices, such as voice prostheses, but it is prone to microbial attachment. Therefore, to deliver a fungal-resistant polymer with key physical properties similar to PDMS (e.g., flexibility), eight homopolymers and 30 subsequent copolymers with varying glass transition temperatures (T g) and fungal antiattachment properties were synthesized and their materials/processing properties studied. Of the copolymers produced, triethylene glycol methyl ether methacrylate (TEGMA) copolymerized with (r)-α-acryloyloxy-β,β-dimethyl-γ-butyrolactone (AODMBA) at a 40:60 copolymer ratio was found to be the most promising candidate by meeting all of the above criteria. This included demonstrating the capability to successfully undergo 3DP by material jetting, via the printing of a voice prosthesis valve-flap using the selected copolymer.

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Invasive Candidiasis in Patients with Implants

Cited by 3 publications

References 53 publications

Rare Pseudotumor in Ceramic-On-Ceramic Total Hip Replacement with Concomitant Fungal Periprosthetic Joint Infection: A Case Report

Rare Pseudotumor in Ceramic-On-Ceramic Total Hip Replacement with Concomitant Fungal Periprosthetic Joint Infection: A Case Report

Thrombin-Derived C-Terminal Peptide Reduces Candida -Induced Inflammation and Infection In Vitro and In Vivo

Fungal Attachment-Resistant Polymers for the Additive Manufacture of Medical Devices

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