Invasive Candidiasis in Patients with Solid Tumors: A Single-Center Retrospective Study

Bai, Xueying; Luo, Jianjun

doi:10.2147/ijgm.s411006

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…8 Chemotherapy-induced neutropenia in cancer patients may result in the emergence of IFI. 9 , 10 Moreover, M. tuberculosis could be a major predisposing factor for IFI particularly in case of invasive aspergillosis. 11 , 12 Based on Hungarian data reported by the European Center for Disease Prevention and Control (ECDC), Candida spp.…”

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confidence: 99%

Unveiling the Hungarian landscape of laboratory and clinical management capacities for invasive fungal infections: navigating the frontlines against fungal menaces

Kovács,

Majoros,

Stemler

et al. 2023

Therapeutic Advances in Infection

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Background: Antifungal diagnostic capacity has been documented in various countries, there is a lack of comprehensive research on clinical mycology diagnostics and treatment in Hungary. Methods: We conducted an online survey encompassing questions that explored various aspects of the mycology diagnostic and antifungal therapy-related information. The survey aimed to gather details about institutional profiles, perceptions of invasive fungal infections (IFIs), and access to microscopy, culture, serology, antigen detection, molecular testing, and therapeutic drug monitoring. Results: As of May 2023, a total of 17 institutions responded to the questionnaire. Seven participants categorized the institutional incidence of IFI as ‘very low’, four as ‘low’, and six as ‘mild’. The majority of centers identified Candida spp. (94%) and Aspergillus spp. (82%) as the most prevalent fungal pathogens. Nearly half of the laboratories (47%) reported using matrix-assisted laser desorption/ionization-time of flight mass spectrometry for identification. All institutions had access to microscopy and culture-based diagnostic approaches. A significant number of centers had access to antigen detection (71%) and various molecular assays (59%). Regarding antifungal agents, all reporting sites used at least one triazole, with voriconazole (77%) being the most common mold-active azole. Furthermore, 71% of the centers applied at least one formulation of amphotericin B, and 65% to one echinocandin. However, only 18% of the centers used 5-flucytosine. Conclusion: Resource availability for diagnosing and treating IFI in Hungary varies across hospitals based on location. Surveys help identify gaps and limitations in this area. To address these challenges, interregional cooperation within Hungary could be a facilitating strategy.

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Section: Introductionmentioning

confidence: 99%

Unveiling the Hungarian landscape of laboratory and clinical management capacities for invasive fungal infections: navigating the frontlines against fungal menaces

Kovács,

Majoros,

Stemler

et al. 2023

Therapeutic Advances in Infection

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Factors’ analysis associated with adverse outcome of the treatment of patients with invasive candidiasis

Popovic,

Begovic-Kupresanin

2023

Srp Arh Celok Lek

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Introduction/Objective. Invasive candidiasis (IC) is the most common invasive fungal infection in humans. It manifests as candidemia, and can affect internal organs and lead to sepsis and septic shock. A good knowledge of the factors that lead to the morbidity and mortality of these patients is necessary. We aimed to investigate the factors associated with the unfavorable outcome of patients with IC treated in our institution. Methods. The research was conducted at the Military Medical Academy in Belgrade, Serbia. The retrospective cohort study included 145 patients of both sexes, aged over 18 years, with a proven diagnosis of invasive candidiasis. Demographics, comorbidities, use of therapeutic procedures, antibiotics, antifungal treatment and outcome were compared between deceased and surviving patients with invasive candidiasis. The results were analyzed using Student's t-test, Mann-Whitney U test, multivariate statistical analysis. Results. The results showed that the predictors of death were DM (adjusted OR 6.886; CI 2.608-18.178; p = 0.000) and chemotherapy (adjusted OR 6.826; 95% CI: 2.037-22.866; p = 0.002), which increase the risk for death seven times compared to the basal risk and mechanical ventilation, which increases the risk of death about three times (adjusted OR: 3.056; 95% CI: 1.132-8.253; p = 0.012). Conclusion. Optimal treatment is necessary in terms of early detection and identification of the causative agent of IC. In susceptible patients, such as immunocompromised patients, appropriate treatment should be initiated as soon as possible.

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Invasive Candidiasis in Patients with Solid Tumors: A Single-Center Retrospective Study

Cited by 2 publications

References 31 publications

Unveiling the Hungarian landscape of laboratory and clinical management capacities for invasive fungal infections: navigating the frontlines against fungal menaces

Unveiling the Hungarian landscape of laboratory and clinical management capacities for invasive fungal infections: navigating the frontlines against fungal menaces

Factors’ analysis associated with adverse outcome of the treatment of patients with invasive candidiasis

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