Invasive cervical cancer in pregnancy

Russa, Mariaclelia La; Jeyarajah, Arjun

doi:10.1016/j.bpobgyn.2015.10.002

Cited by 21 publications

(25 citation statements)

References 65 publications

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“…Regarding pre-invasive lesions of the cervix, 2-6.5% of cervical intraepithelial neoplasia (CIN)/squamous intraepithelial lesion (SIL) cases present during gestation; 10-50 cases of cancer have been reported per 100,000 gestations ( 18 ). In addition, 1.9% of microinvasive cancer cases are diagnosed during pregnancy ( 19 ). Pap smears as well as colposcopy should be performed as a routine examination for the diagnosis of pre-invasive lesions during pregnancy.…”

Section: Pre-invasive and Invasive Lesions Of The Cervix During Pregnmentioning

confidence: 99%

“…For stage IA1, cone biopsy is preferred with no additional treatment required (1.2% risk of lymph node metastases), with vaginal delivery being the preferred mode of delivery ( 23 ). For stage IA2, cone biopsy combined with pelvic lymph node dissection during pregnancy and excision of the cervix immediately following delivery is recommended ( 19 ). With regards to stage IA2 and IIA, a C-section followed by radical hysterectomy and lymph node dissection is recommended.…”

Section: Pre-invasive and Invasive Lesions Of The Cervix During Pregnmentioning

confidence: 99%

“…Prognosis of cervical cancer is not affected by gestation. Twenty percent of cases are diagnosed due to post-coital bleeding, and 63% do not present with an abnormal Pap smear ( 19 ). Mortality is low, and the survival rate is up to 95%.…”

Section: Pre-invasive and Invasive Lesions Of The Cervix During Pregnmentioning

confidence: 99%

“…Thus, the authors suggested delaying delivery to a gestational age of 37-39 weeks, especially considering the significant morbidity and mortality associated with preterm delivery ( 35 , 36 , 37 , 38 ). Conversely, a number of recent publications regarding cervical cancer in pregnancy suggested preterm delivery in order to initialize treatment earlier ( 19 , 35 , 39 ). In addition, in a study by Xia et al ( 33 ), delayed intervention was associated with decreased survival.…”

Section: Pre-invasive and Invasive Lesions Of The Cervix During Pregnmentioning

confidence: 99%

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Current management of gynecologic cancer in pregnancy

Iavazzo¹,

Minis²,

Gkegkes³

2018

J Turkish German Gynecol Assoc

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Cancer during pregnancy is a particularly challenging complication. The incidence has increased in recent years due to childbearing at advanced maternal ages due to career choices and/or the development of reproductive technology. Approximately two thirds of cancer cases during pregnancy comprise invasive cervical cancers and breast cancer. Cancer during gestation is characterized by a need for specialized treatment due to major changes in the hormonal profile (estrogen-progesterone), metabolism (enhancement of anabolism), hemodynamic changes (hyperdynamic circulation), immunologic changes (cell-mediated and humoral immunity), and increased angiogenesis (increased blood flow towards the uterus). Moreover, the management of such patients is based on the trimester of pregnancy, type and stage of cancer, and informed consent of the mother based on her wishes. The optimal treatment of cancer during pregnancy remains elusive because there are limited data from retrospective studies with small samples. As a result, it is crucial that data regarding survival of the women and long-term follow-up of the children from different cancer centers and registries are shared. This need is dictated by the fact that the incidence of cancer during pregnancy will continue to rise as child-bearing age continues to increase.

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Section: Pre-invasive and Invasive Lesions Of The Cervix During Pregnmentioning

confidence: 99%

Section: Pre-invasive and Invasive Lesions Of The Cervix During Pregnmentioning

confidence: 99%

Section: Pre-invasive and Invasive Lesions Of The Cervix During Pregnmentioning

confidence: 99%

Section: Pre-invasive and Invasive Lesions Of The Cervix During Pregnmentioning

confidence: 99%

See 2 more Smart Citations

Current management of gynecologic cancer in pregnancy

Iavazzo¹,

Minis²,

Gkegkes³

2018

J Turkish German Gynecol Assoc

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“…When it comes to the more advanced stages of the disease, the management of the oncological process takes into consideration the size of the tumour, the histopathological subtype, the lymph node status, the stage of pregnancy as well as the woman's wish according to the on-going pregnancy and to her obstetrical future 1 . However, a standard therapeutic protocol for such cases is still missing 1,11,13 .…”

Section: Management Of Neoplastic Lesions Of Uterine Cervix During Prmentioning

confidence: 99%

Management of cervical cancer during pregnancy– literature review

Bodog¹,

Bacalbaşa²,

Bălescu³

et al. 2018

Arch Balk Med Union

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Approche du cancer du col utérin pendant la grossesse-revue de la littérature Bien que l'incidence exacte des cas de cancer du col de l'utérus chez la femme enceinte ne soit pas connue, il s'agit sans aucun doute de la tumeur maligne gynécologique la plus courante diagnostiquée pendant la grossesse. L'association entre les deux entités ne semble pas influencer les résultats oncologiques. Cependant, la gestion de ces cas reste un véritable défi pour l'obstétricien et pour le gynéco-oncologue, se battre pour deux vies étant nécessaire. De plus, en raison de la rareté des cas, il n'existe pas de directives standard, la stratégie thérapeutique n'est influencée que par de petites séries de cas et des études observationnelles. Ceci est une revue de la littérature des options thérapeutiques actuelles disponibles pour la gestion de tels cas.

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Definite Treatment Delay With Neoadjuvant Chemotherapy and Longitudinal Monitoring by Circulating Tumor DNA for Advanced Cervical Cancer During Pregnancy: A Case Series and Literature Review

Zhang,

Yu,

Chen

et al. 2024

Cancer Reports

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BackgroundPrevious studies mainly concentrate on neoadjuvant chemotherapy (NACT) for delivery delay in FIGO Stage IB1–IIIB cervical cancer during pregnancy to prevent early preterm delivery while not affecting maternal outcome.CaseHere, we described two pregnant patients with FIGO Stage IIIC cervical cancer about their diagnosis, treatment, and outcome. Both patients underwent cesarean delivery, left enlarged lymph node dissection, and longitudinal monitoring by circulating tumor DNA. Our study suggested that pregnant patient was completely response to NACT, which was confirmed by ctDNA monitoring, followed by left pelvic enlarged lymph node dissection during cesarean section and adjuvant chemoradiotherapy postpartum. The infant grew normally, without any evidence of chemotherapy‐related side effects after delivery.ConclusionIn pregnant women with advanced cervical cancer, longitudinal ctDNA monitoring might be able to evaluate maternal response to NACT and confirm if delivery delay to optimize fetal outcome would compacting the maternal outcomes or not. Cervical cancer may not transmit across the placental barrier and so it is safe for delayed delivery until fetal maturity in utero during pregnancy.

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Invasive cervical cancer in pregnancy

Cited by 21 publications

References 65 publications

Current management of gynecologic cancer in pregnancy

Current management of gynecologic cancer in pregnancy

Management of cervical cancer during pregnancy– literature review

Definite Treatment Delay With Neoadjuvant Chemotherapy and Longitudinal Monitoring by Circulating Tumor DNA for Advanced Cervical Cancer During Pregnancy: A Case Series and Literature Review

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