Invasive Cribriform Carcinoma Arising in Malignant Phyllodes Tumor of Breast: A Case Report

Abstract

Phyllodes tumor is an uncommon fibroepithelial neoplasm of the breast. And it is characterized by expanded stroma with increased cellularity and elongated epithelium-lined clefts. Mammary carcinomas within phyllodes tumors have been rarely reported. To date, however, no reports have described the invasive cribriform carcinoma arising in malignant phyllodes tumor. Here, we report a 62-year-old woman who presented with a large breast mass. Microscopically, the mass was a typical malignant phyllodes tumor showing well developed leaf-like architecture and stromal overgrowth with high cellularity and nuclear pleomorphism. In a portion of the tumor, however, the epithelial component showed a cribriform pattern of proliferation in the absence of myoepithelial cells, suggestive of the invasive cribriform carcinoma. To our knowledge, this is rare and it is difficult to make a differential diagnosis of it. Here, we report our case with a review of literatures.

High-grade ductal carcinoma in-situ detected by microcalcification within borderline phyllodes tumour: A report of a case and literature review

“…Including this case study, 47 published cases were analysed (Table 1) (2,(4)(5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(23)(24)(25)(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41). All of them were female patients aged between 19 and 80 years old (mean age = 47.6 years old and median age = 49 years old).…”

Invasive ductal carcinoma within borderline phyllodes tumor with lymph node metastases: A case report and review of the literature

“…As there is no standard adjuvant treatment strategy for this type of disease, a variety of systemic therapies were applied to the various cases. In total, 6 cases received chemotherapy with various regimens (16,(19)(20)(21)(22)(23), 5 cases received radiotherapy (13,16,18,20), and 4 cases received endocrine therapy, 3 of which received tamoxifen (1,16,21) and 1 received tamoxifen and goserelin (19). Patient outcomes were described in 19 cases.…”

Cribriform carcinoma arising in a benign phyllodes tumor

“…[ 1 ] The epithelial component within phyllodes tumor may show proliferative changes with rare occurrences of malignant transformation. [ 2 3 ] These carcinomas were reported to occur either within or adjacent to phyllodes tumors in the ipsilateral or contralateral breast. They can occur in conjunction with benign, borderline, or malignant phyllodes.…”

“…They can occur in conjunction with benign, borderline, or malignant phyllodes. [ 2 3 4 5 ] In many instances, the carcinomatous components were identified incidentally on histopathological evaluation.…”

“…Types of carcinoma component arising within a phyllodes tumor that has been reported include ductal carcinoma in situ (DCIS), mixed DCIS and invasive carcinoma, invasive carcinoma, lobular carcinoma in situ , invasive lobular carcinoma, and neuroendocrine carcinoma. [ 3 4 ] Two previous cases of invasive cribriform carcinoma were reported to arise within a malignant and borderline phyllodes tumor, respectively. [ 3 5 ] Our case showed invasive cribriform carcinoma arising within a benign phyllodes tumor, which would be the first case report to date.…”