Invasive disease by Streptococcus pyogenes: Patients hospitalized for 6 years

Arias-Constantí, Vanessa; Maza, Victoria Trenchs Sainz de la; Sanz-Marcos, Nuria Elvira; Guitart, Carmina; Gené-Giralt, Amadeu; Luaces-Cubells, Carles

doi:10.1016/j.eimce.2018.04.007

Cited by 3 publications

(2 citation statements)

References 17 publications

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“…However, this prevalence is comparable to the rates observed for purulent meningitis in infections caused by other pathogense.g. Streptococcus pyogenes -5,4 to 7, 7%, Streptococcus pneumoniae and Haemophilus influenzae both around 4% [19][20][21][22][23]. On the other hand, the prevalence of purulent meningitis in infections caused by Neisseria meningitidis is substantially higher, between 40 and 65%, depending on individual serotypes and regional differences [24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 99%

A rare case of purulent meningitis caused by Capnocytophaga canimorsus in the Czech Republic – case report and review of the literature

et al. 2020

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Background: Invasive infections caused by Capnocytophaga canimorsus are rare. Immunocompromised patients, who report being bitten by or having a close contact with an animal, represent a high-risk group for this infection. There are only few dozens of infections by this bacteria manifesting as purulent meningitis reported worldwide. The reported case is a first reported case of purulent meningitis caused by by Capnocytophaga canimorsus in Czech Republic with only a limited risk factor history. Case presentation: The patient, a 74 years old man, was referred to the infectious diseases department of a teaching hospital with clear signs of developing purulent meningitis. His anamnestic data did not show any unusual findings. He was treated for compensated diabetes mellitus type II. The blood cultures were negative and the etiological agent did not grow from the cerebrospinal fluid (CSF) on common media. Eventually, it was identified by detecting pan-bacterial DNA and DNA sequencing. Subsequently, the pathogen was confirmed by anaerobic cultivation from CSF. Only after then the patient recalled being bitten by his German shepherd puppy during play. The patient was successfully treated intravenously by ceftriaxone. Conclusions: Purulent meningitis caused by Capnocytophaga spp. is a rare disease, but it needs to be considered in patients at risk with pre-existing conditions, who report close contact with or being bitten by an animal. It is important to test for this microbe in cases with negative microbiological results for the more common agents.

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Section: Discussionmentioning

confidence: 99%

A rare case of purulent meningitis caused by Capnocytophaga canimorsus in the Czech Republic – case report and review of the literature

et al. 2020

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“…Gram-positive bacteria such as Streptococcus pyogenes , also known as the group A streptococci (GAS) and Staphylococcus aureus are among the most common human pathogens that cause a wide variety of diseases ranging from skin and soft tissue injuries to life-threatening illness [ 1 , 2 , 3 , 4 , 5 ]. An increase in the incidence of invasive infection caused by these two Gram-positive cocci has been reported in the past years [ 6 , 7 , 8 , 9 ]. The nasopharyngeal mucosa and associated lymphoid tissues are the most common sites of entry for GAS, which, however, may colonize and persist transiently in humans, often throughout childhood, without overt symptoms of disease [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

The Relevance of IL-1-Signaling in the Protection against Gram-Positive Bacteria

et al. 2021

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Previous studies performed using a model of group B streptococcus (GBS)-induced peritoneal inflammation indicate that the interleukin-1 receptor (IL-1R) family plays an important role in the innate host defense against this encapsulated Gram-positive bacteria. Since the role of IL-1-dependent signaling in peritoneal infections induced by other Gram-positive bacteria is unknown, in the present study we sought to investigate the contribution of IL-1R signaling in host defenses against Streptococcus pyogenes (group A streptococcus or GAS) or Staphylococcus aureus, two frequent and global human Gram-positive extracellular pathogens. We analyzed here the outcome of GAS or S. aureus infection in IL-1R-deficient mice. After inoculated intraperitoneal (i.p.) inoculation with group A Streptococcus or S. aureus, all the wild-type (WT) control mice survived the challenge, while, respectively, 63% or 50% of IL-1-defective mice died. Lethality was due to the ability of both bacterial species to replicate and disseminate to the target organs of IL-1R-deficient mice. Moreover, the experimental results indicate that IL-1 signaling promotes the production of leukocyte attractant chemokines CXCL-1 and CXCL-2 and recruitment of neutrophils to bacterial infection sites. Accordingly, the reduced neutrophil recruitment in IL-1R-deficient mice was linked with decreased production of neutrophil chemokines. Collectively, our findings indicate that IL-1 signaling, as previously showed in host defense against GBS, plays a fundamental role also in controlling the progression and outcome of GAS or S. aureus disease.

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Adjunctive antibiotic therapy with clindamycin or linezolid in patients with group A streptococcus (GAS) meningitis

Rezahosseini

Roed

Holler

et al. 2023

Infectious Diseases

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Invasive disease by Streptococcus pyogenes: Patients hospitalized for 6 years

Cited by 3 publications

References 17 publications

A rare case of purulent meningitis caused by Capnocytophaga canimorsus in the Czech Republic – case report and review of the literature

A rare case of purulent meningitis caused by Capnocytophaga canimorsus in the Czech Republic – case report and review of the literature

The Relevance of IL-1-Signaling in the Protection against Gram-Positive Bacteria

Adjunctive antibiotic therapy with clindamycin or linezolid in patients with group A streptococcus (GAS) meningitis

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