Invasive Disease Due to Group B Streptococcus in Pregnant Women and Neonates from Diverse Population Groups

Zaleznik, Dori F.; Rench, Marcia A.; Hillier, Sharon L.; Krohn, Marijane A.; Platt, Richard; Lee, Mei Ling T.; Flores, Aurea E.; Ferrieri, Patricia; Baker, Carol J.

doi:10.1086/313665

Cited by 176 publications

(142 citation statements)

References 20 publications

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“…Around 68 of 110 women The strong evidence for the usefulness of the universal screening at 35 to 37 weeks of pregnancy to prevent GBS neonatal infection was mainly drawn from studies conducted in the United States. [2][3][4][5][6][7] However, GBS is present worldwide and the prevalence of GBS carriers varies in relation to the geographical area and/or a number of demographic factors. [8][9][10][11][12][13][14][15] In the present study, the prevalence of anogenital carriage of GBS was 12.15%.…”

Section: Discussionmentioning

confidence: 99%

Group B Streptococci Colonization in Pregnant Women: Is Screening Necessary?

Patil¹,

Singla²,

Nagmoti³

2013

Journal of South Asian Federation of Obstetrics and Gynaecology

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Objectives: Group B Streptococcus (GBS) has been recognized as the leading cause of serious neonatal infections through mother-fetal vertical transmission in the west, however, in India, its spectrum is largely under estimated. The present study was carried out to find the incidence of rectovaginal carriage of GBS in parturient women, association with risk factors in mother and to study the neonatal outcome. Materials and methods:A one year cross-sectional prospective study was carried out in 905 parturient women admitted at a tertiary care center meeting the selection criteria over a period of one year from June 2007 to May 2008. The inclusion criteria were all pregnant women admitted to the labor room after 35 ± 1 week of gestation. Rectal and vaginal swabs were taken and cultured on selective Todd-Hewitt broth medium followed by sub culture on blood agar and confirmation by Latex agglutination test from all the women meeting the inclusion criteria. The outcomes measured were the incidence, antenatal risk factors in mother and the neonatal outcome. Analysis was done using paired 't' test, chi-square test and a p-value of <0.05 was taken as statistically significant. Results:Incidence of group B Streptococcus (GBS) was 12.15% and detection rate was increased by 4.6% with the inclusion of rectal swabs for culture. GBS carriage was significantly increased with preterm birth (OR 8.3, 95% CI,1.1-15.5), premature rupture of membranes (OR 7.5, 95% CI, 1.1-13.4), prolonged duration of ruptured membranes more than 10 hours (OR 21, 95% CI,15.2-34.2) and intrapartum temperature more than 38°C(OR 3.1, 95% CI, 0.43-6.66). Birth weight less than 2.5 kg and neonatal intensive care admissions were significantly more (35.45%) in infants of GBS positive women. Conclusion:GBS colonization was more frequent in women with risk factors. GBS pick up rate was increased by the inclusion of both rectal and vaginal swabs.

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Section: Discussionmentioning

confidence: 99%

Group B Streptococci Colonization in Pregnant Women: Is Screening Necessary?

Patil¹,

Singla²,

Nagmoti³

2013

Journal of South Asian Federation of Obstetrics and Gynaecology

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“…Este serotipo es uno de los más frecuentes en la actualidad en infecciones invasivas en adultos con condiciones predisponentes y menos frecuente en infecciones invasivas maternas y neonatales 14,27,28 .…”

Section: N V E S T I G a C I ó Nunclassified

Serotipos y susceptibilidad antimicrobiana de Streptococcus agalactiae

et al. 2004

Rev. méd. Chile

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“…About 1% of these infants develop the sepsis syndrome and, depending on the gestational age, up to 42% of affected infants may die. Approximately one-half of infants that survive GBS meningitis suffer permanent neurological impairment (3).…”

Section: G Roup B Streptococcus (Gbs)mentioning

confidence: 99%

Novel Engagement of CD14 and Multiple Toll-Like Receptors by Group B Streptococci

Henneke

Takeuchi

Strijp³

et al. 2001

The Journal of Immunology

131

132

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Group B streptococcus (GBS) imposes a major health threat to newborn infants. Little is known about the molecular basis of GBS-induced sepsis. Both heat-inactivated whole GBS bacteria and a heat-labile soluble factor released by GBS during growth (GBS-F) induce nuclear translocation of NF-κB, the secretion of TNF-α, and the formation of NO in mouse macrophages. Macrophages from mice with a targeted disruption of MyD88 failed to secrete TNF-α in response to both heat-inactivated whole bacteria and GBS-F, suggesting that Toll-like receptors (TLRs) are involved in different aspects of GBS recognition. Immune cell activation by whole bacteria differed profoundly from that by secreted GBS-F. Whole GBS activated macrophages independently of TLR2 and TLR6, whereas a response to the secreted GBS-F was not observed in macrophages from TLR2-deficient animals. In addition to TLR2, TLR6 and CD14 expression were essential for GBS-F responses, whereas TLR1 and TLR4 or MD-2 did not appear to be involved. Heat lability distinguished GBS-F from peptidoglycan and lipoproteins. GBS mutants deficient in capsular polysaccharide or β-hemolysin had GBS-F activity comparable to that of wild-type streptococci. We suggest that CD14 and TLR2 and TLR6 function as coreceptors for secreted microbial products derived from GBS and that cell wall components of GBS are recognized by TLRs distinct from TLR1, 2, 4, or 6.

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Invasive Disease Due to Group B Streptococcus in Pregnant Women and Neonates from Diverse Population Groups

Cited by 176 publications

References 20 publications

Group B Streptococci Colonization in Pregnant Women: Is Screening Necessary?

Group B Streptococci Colonization in Pregnant Women: Is Screening Necessary?

Serotipos y susceptibilidad antimicrobiana de Streptococcus agalactiae

Novel Engagement of CD14 and Multiple Toll-Like Receptors by Group B Streptococci

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