Invasive ductal carcinoma of the breast with clear cell and pseudo-lactating changes

Ovanez, Christopher; Crawford, Joel M.; Asarian, Armand; Xiao, Philip

doi:10.1093/jscr/rju063

Cited by 6 publications

(3 citation statements)

References 9 publications

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“…GRCCC may form solid and papillary structures [ 7 ]. Clear cell breast carcinoma can be easily missed or misdiagnosed in a breast core biopsy specimen because it tends to show a papillary pattern with clear cell and pseudolactating changes, especially in young female patients [ 8 ]. Normal breast tissue may include clear cells as a consequence of physiological changes during pregnancy, and a clear cytoplasm may be found in myoepithelial cells and/or apocrine metaplasia.…”

Section: Discussionmentioning

confidence: 99%

Clear Cell Carcinoma of the Breast: A Rare Breast Cancer Subtype - Case Report and Literature Review

Ratti

Pagani

2015

Case Rep Oncol

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Background: Glycogen-rich clear cell breast carcinoma is a rare histological breast cancer subtype. Its prognosis may vary depending on specific clinical and pathological characteristics such as low grade, strong positivity of estrogen receptor (ER) expression and early diagnosis. Case Presentation: We present the case of a 53-year-old woman with a bleeding 10-cm-diameter mass in the left breast. The histological examination showed a poorly differentiated tumor with malignant cells characterized by abundant clear cytoplasm. The diagnosis of clear cell carcinoma was based on the histological characteristics of the tumor, and a nonmammary origin was initially ruled out. The tumor was triple negative [i.e. ER, progesterone receptor (PR) and HER2 negative]. Four months after the initial locoregional treatment, the patient developed lung and distant lymph node metastases. Conclusions: Glycogen-rich clear cell carcinoma of the breast is a rare tumor. Early diagnosis, absence of lymph node metastases and ER/PR positivity are associated with a better prognosis, as in other common breast cancer subtypes.

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Section: Discussionmentioning

confidence: 99%

Clear Cell Carcinoma of the Breast: A Rare Breast Cancer Subtype - Case Report and Literature Review

Ratti

Pagani

2015

Case Rep Oncol

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“…Thus, breast ducts and lobules may undergo clear changes during the pregnancy, where the clearing of the cytoplasm typically affects myoepithelial cells and the clearing of the cytoplasm that may be seen in benign changes such as apocrine metaplasia. 4…”

Section: Definitionmentioning

confidence: 99%

Glycogen-rich Clear Cell Carcinoma of the Breast: A Comprehensive Review

Vranić

Skenderi²,

Beslagic

et al. 2020

Applied Immunohistochemistry &Amp; Molecular Morphology

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Glycogen-rich clear cell carcinoma (GRCC) is a very rare form of primary breast cancer (< 0.1% of all breast cancers). It is characterized by the presence of neoplastic cells with a glycogen-abundant clear cytoplasm (the Periodic Acid Schiffpositive, diastase-sensitive). The expression of steroid receptors (estrogen and progesterone receptors) has been variably reported (35% to 100% of the cases), whereas most studies reported low human epidermal growth factor receptor 2 positivity in GRCC. High androgen receptor positivity without androgen receptor splice variant-7 was reported in one recent study. Although sparse, the preliminary theranostic data on GRCC indicate the potential of targeted treatments in selected cases (antiandrogen, PIK3CA, and immune checkpoint inhibitors). Because of its rarity, the prognosis for GRCC patients remains controversial. Herein, we comprehensively appraise the epidemiological, morphologic, molecular, and clinical characteristics of this rare mammary malignancy.

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“…Сложность верификации СРМЖ заключается в том, что данный вид рака часто «маскируется» под метастазы других злокачественных новообразований, например светлоклеточной почечно-клеточной карциномы, для чего дополнительно необходимо проведение гистохимических (PAS-реакции) и ИГХ-реакций. Кроме того, СРМЖ может сочетаться с другими опухолями [5] либо принимать папиллярный вид или картину ложной лактации у молодых пациенток [8]. Вследствие редкости СРМЖ, от 1 до 3 % от общего числа первичных злокачественных опухолей молочной железы [1], трудно достоверно судить о прогнозе данного типа рака.…”

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