Invasive extramammary Paget's disease of the bladder diagnosed 18years after noninvasive extramammary Paget's disease of the vulva

Onaiwu, Cherry O.; Ramírez, Pedro T.; Kamat, Ashish M.; Pagliaro, Lance C.; Euscher, Elizabeth D.; Schmeler, Kathleen M.

doi:10.1016/j.gynor.2014.03.004

Cited by 7 publications

(14 citation statements)

References 7 publications

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“…The majority of patients had multiple recurrences, with 18.0% of patients having four or more recurrences, including one patient who was treated for 10 recurrences (Onaiwu et al, 2014). The most common treatment for recurrent disease was surgery with 38 of the 52 patients (73.1%) undergoing one or more procedures, 21 (40.4%) patients underwent two or more surgical procedures, and 10 (19.2%) underwent three or more surgical procedures.…”

Section: Resultsmentioning

confidence: 99%

“…It is a disease more often diagnosed in Caucasian, postmenopausal women (Kay and Southwood, 1964, Tebes et al, 2002, Black et al, 2007). Patients with Paget's disease of the vulva are at risk for a second synchronous or metachronous neoplasm: colorectal adenocarcinoma, cervical adenocarcinoma, carcinoma of the transitional epithelium from the renal pelvis to urethra, breast and vulvar carcinoma (Preti et al, 2000, Onaiwu et al, 2014). Routine screening with colonoscopy, Pap test, mamogram and cystoscopy is therefore recommended (Tebes et al, 2002, Feuer et al, 1990).…”

Section: Introductionmentioning

confidence: 99%

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Paget's disease of the vulva: A review of 89 cases

Onaiwu

Salcedo²,

Pessini³

et al. 2017

Gynecologic Oncology Reports

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The purpose of this study was to retrospectively review the clinical characteristics and outcomes of a series of women with Paget's disease of the vulva. A retrospective review was performed of 89 women with Paget's disease of the vulva evaluated at a single institution between 1966 and 2010. Medical records were reviewed for demographic information, clinical data, pathologic findings, treatment modalities and outcomes. We found that the primary treatment was surgery for 74 (83.1%) patients, with positive margins noted in 70.1% of cases. Five patients (5.6%) underwent topical treatment with imiquimod and/or 5-fluorouracil, one patient (1.1%) underwent laser ablation and treatment was unknown in 9 patients (10.1%). The majority of patients had multiple recurrences, with 18% having four or more recurrences. There were no significant differences in recurrence rates between patients who underwent surgery and those who did not. Furthermore, there was no association between positive margins following primary surgery and recurrence. Forty-one patients (46.1%) were diagnosed with 53 synchronous or metachronous cancers. Seven patients (7.9%) were found to have invasive vulvar cancer with 1 mm or more depth of invasion, but none of the patients died of Paget's disease or associated vulvar/vaginal cancer. Our findings suggest that the majority of patients with Paget's disease of the vulva develop multiple recurrences regardless of treatment modality or margin status. Alternatives to surgery are needed to better care for women with this disease.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Paget's disease of the vulva: A review of 89 cases

Onaiwu

Salcedo²,

Pessini³

et al. 2017

Gynecologic Oncology Reports

Self Cite

View full text Add to dashboard Cite

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“…Other factors associated with EMPD of the vulva include caucasian race, genetic predisposition, previous radiation exposure, increased body mass index and history of hormone replacement therapy 9…”

Section: Descriptionmentioning

confidence: 99%

“…Therefore, routine screening in some cases and prolonged surveillance has been recommended, although there are no clear guidelines. Recommended screening tests to rule out co-existing malignancies include, colonoscopy, cervical cytology, mammogram, cystoscopy, and/or urinary cytology to rule out coexisting or underlying malignancies 7–10…”

Section: Descriptionmentioning

confidence: 99%

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Extensive extramammary Paget’s disease of the vulva involving the bladder postradical split skin graft reconstruction

Mujukian¹,

Innamaa

Lippiatt

et al. 2019

BMJ Case Rep

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Extensive Invasive Extramammary Paget Disease Evaluated by F-18 FDG PET/CT

Qin

2015

Medicine

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Extramammary Paget disease (EMPD) is a rare cutaneous, intraepithelial adenocarcinoma. Because of its rarity, little is known about the value of fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) in evaluating this disease. Our case report aims to increase current knowledge of FDG PET/CT in EMPD as a noninvasive imaging tool for assessing the extension of the disease and detecting distant metastases.We reported a 64-year-old Chinese man who presented with a slowly progressive, ill-margined erythematous lesion with a crusted, eroded, and scaly surface involving multiple sites of penis, scrotum, left pelvic wall, hip, groin, and thigh for >4 years, which became extensive in the past 1 year. He was referred for an FDG PET/CT examination to further evaluate the lesions. A following skin biopsy was performed to obtain a definitive histological diagnosis.FDG PET/CT imaging revealed mild FDG uptake at the extensive cutaneous lesion with subcutaneous invasion, involvement of lymph nodes, and multiple intense FDG-avid of skeletal metastases. According to the appearance of FDG PET/CT, a provisional diagnosis of advanced cutaneous malignancy was made. Histopathology findings indicated characteristic of EMPD. The patient was treated with radiation therapy and died from complications 2 months after the last dose of radiotherapy.Our case highlighted that a whole-body FDG PET/CT should be incorporated into the diagnostic algorithm of EMPD to give a comprehensive assessment of this disease.

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Invasive extramammary Paget's disease of the bladder diagnosed 18years after noninvasive extramammary Paget's disease of the vulva

Cited by 7 publications

References 7 publications

Paget's disease of the vulva: A review of 89 cases

Paget's disease of the vulva: A review of 89 cases

Extensive extramammary Paget’s disease of the vulva involving the bladder postradical split skin graft reconstruction

Extensive Invasive Extramammary Paget Disease Evaluated by F-18 FDG PET/CT

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