Invasive fungal infections in recipients of allogeneic hematopoietic stem cell teens and young adults

Popova, M.; Ekushov, Kirill Alexandrovich; Айзсилниекс, О. В.; Волкова, А. Г.; Пинегина, О Н; Игнатьева, С М; Слесарчук, О. А.; Владовская, М Д; Bondarenko, Sergey N.; Зубаровская, Л. С.; Климко, Н. Н.; Афанасьев, Б. В.

doi:10.17650/2311-1267-2016-3-1-44-51

Cited by 4 publications

(2 citation statements)

References 17 publications

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“…Pulmonary infections before allo-HSCT were in 44.9% of patients, among which pneumonia (35.8%), invasive mycosis (16%) and TBC (2.8%) prevailed. These data are similar to the results previously published by our group [31]. History of potential pulmonary toxic chemotherapy was documented in 72% of patients.…”

Section: Clinical Studiessupporting

confidence: 91%

Clinical features and prognostic value of functional disorders and pulmonary comorbidity in adult patients prior to allogeneic hematopoietic stem cell transplantation

Кулагин¹,

Волкова²,

Nikolaev³

et al. 2019

CTT

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High efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in a wide range of malignant and non-malignant hematopoietic disorders system is limited to the risk of serious complications and non-relapse mortality (NRM). Pre-existing comorbidities before allo-HSCT are among key factors for NRM. The purpose of this study was to characterize the potential pre-transplant factors of pulmonary comorbidity and integral indicators of pulmonary function tests (PFT) and to evaluate their prognostic value for the allo-HSCT outcomes in adult patients.

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Section: Clinical Studiessupporting

confidence: 91%

Clinical features and prognostic value of functional disorders and pulmonary comorbidity in adult patients prior to allogeneic hematopoietic stem cell transplantation

Кулагин¹,

Волкова²,

Nikolaev³

et al. 2019

CTT

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“…Неуклонно прогрессируя, без адекватной антимикотической терапии инвазивный аспергиллез ЦНС характеризуется крайне неблагоприятным для жизни и здоровья пациентов прогнозом [2]. Ранняя диагностика, своевременное начало интенсивной, комбинированной этиотропной антимикотической терапии, контроль ее эффективности с использованием визуализирующих и лабораторных методов исследования позволяют добиться регресса грибкового поражения ЦНС у таких больных [1,6,7].…”

Section: выводыunclassified

Case of successful treatment of neuroaspergillosis in oncological patient

Изможерова

Кулева

Иванова

et al. 2019

Ross. ž. det. gematol. onkol.

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Invasive mycoses caused by fungi of the genus Aspergillus, today remain an urgent clinical problem in oncological patients. In 10–20 % of patients with primary by aspergilloma can be detected in the Central nervous system. The article describes a case of neuroaspergillosis in an immunocompromised patient with choroid carcinoma of the right parietal-occipital lobe of the brain. Correct interpretation of risk factors, clinical symptoms and imaging techniques, early diagnosis with verification the pathological process, the use of fungistatic and fungicidal drugs allowed to avoid the negative consequences of fungal neuroinfection.

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Invasive aspergillosis caused by <i>Aspergillus non-fumigatus</i> after allogeneic hematopoietic stem cell transplantation

Markelov

Rogacheva

Popova

et al. 2022

jour

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Objective. To study the features of invasive aspergillosis (IA) due to A. non-fumigatus versus A. fumigatus in adult (≥ 18 years) recipients of allogeneic hematopoietic stem cell transplantation (allo-HSCT) in 2016-2021. Materials and methods. The study included 33 patients with IA caused by A. non-fumigatus (n = 20) and A. fumigatus (n = 13). A comparative analysis of cases of IA, the results of therapy and outcomes in patients after allo-HSCT in the RM Gorbacheva Research Institute was performed. Diagnostic criteria EORTC / MSGERC 2020 were used. Results. Invasive aspergillosis caused by A. non-fumigatus made up the majority (60.6 %) of IA cases with an identified pathogen registered in patients after allo-HSCT in the period from 2016 to 2021. The main etiological agents in the A. non-fumigatus group were A. niger in 13 (65 %) patients, A. flavus – in 4 (20 %). The median day of diagnosis of A. non-fumigatus IAwas + 110 days (17–2093), for A. fumigatus it was + 46 days (2–866) (p = 0.171). Overall 12-week survival was 55 % and 59.2 % in the A. non-fumigatus and A. fumigatus groups, respectively (p = 0.617). The majority of patients in both the A. fumigatus (n = 10, 77 %) and A. non-fumigatus (n = 16, 80 %) groups received voriconazole as initial antifungal therapy. Second-linetherapy was required in 2 (10 %) patients with A. non-fumigatus IA: liposomal amphotericin B and echinocandins with or with-out posaconazole, and 2 (15 %) patients in the A. fumigatus group: liposomal amphotericin B and voriconazole in combination with echinocandins. A comparative analysis showed that in patients from the two groups, none of the assessed signs (gender, age, underlying disease, disease status at the time of transplantation, time from diagnosis to allo-HSCT, source of hematopoietic stem cells, conditioning regimen, donor type, antifungal prophylaxis, cytomegalovirus reactivation, severe acute and chronic graft-versus-host disease) did not differ significantly. Conclusions. A. niger is the main causative agent of IA caused by A. non-fumigatus. Patients characteristics, their treatment and outcomes did not differ significantly between the A. non-fumigatus and A. fumigatus groups.

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Invasive fungal infections in recipients of allogeneic hematopoietic stem cell teens and young adults

Cited by 4 publications

References 17 publications

Clinical features and prognostic value of functional disorders and pulmonary comorbidity in adult patients prior to allogeneic hematopoietic stem cell transplantation

Clinical features and prognostic value of functional disorders and pulmonary comorbidity in adult patients prior to allogeneic hematopoietic stem cell transplantation

Case of successful treatment of neuroaspergillosis in oncological patient

Invasive aspergillosis caused by <i>Aspergillus non-fumigatus</i> after allogeneic hematopoietic stem cell transplantation

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