Invasive fungal infections in renal transplant recipients

Nampoory, M.R.N.; Khan, Zia U.; Johny, K.V.; Constandi, J. N.; Gupta, Ram Kumar; Al-Muzairi, I.; Samhan, M; Mozavi, M.; Chugh, T.D.

doi:10.1016/s0163-4453(96)92986-2

Cited by 111 publications

(87 citation statements)

References 11 publications

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“…In two cases, like in our patient, the disease was manifested early -on POD 14 [S] and 17 [6], with massive involvement of the transplanted kidney and no evidence of another portal of entry (pulmonary or rhinocerebral). Diagnosis was made by graft biopsy on POD 25 [6] and POD 30 [8]. Graft nephrectomy was performed, and antifungal treatment was initiated immediately after diagnosis.…”

Section: Discussionmentioning

confidence: 99%

“…In the third patient, diagnoses was established only after graft nephrectomy at 2.5 months posttransplant, which followed a complicated course of CMV nephritis and acute rejection [14]. One patient died [8] and two survived [6,141. Interestingly, as in our patient, in all three cases, fungal infection followed treatment for rejection, and in two cases [S, 141 it was associated with CMV infection representing a net state of immunosuppression.…”

Section: Discussionmentioning

confidence: 99%

“…In some third-world countries, organs are not uncommonly purchased and harvested under sub-optimal conditions; this practice may explain such findings and may also serve as an argument against living unrelated kidney transplantation. Nampoory et al found that 78% of 18 fungal infections, including the case of graft zygomicosis, occurred after living unrelated kidney transplantation [8].…”

Section: Discussionmentioning

confidence: 99%

“…His immediate postoperative course was uneventful except for an episode of mild acute rejection, which was diagnosed on biopsy and treated with steroid bolus. The patient returned to Israel on POD 8 and was admitted to another hospital for continuity of care. On admission, he was jaundiced.…”

Section: Case Reportmentioning

confidence: 99%

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Mucormycosis of the renal allograft: case report and review of the literature

Chkhotua¹,

Yussim²,

Tovar³

et al. 2001

Transplant International

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Fungal infection is an uncommon complication after renal transplantation. We describe a rare form of mucormycosis in the renal graft. Our method was to review chart data and to perform medline searches. The patient was a 42-yearold man who underwent living-unrelated kidney transplantation in Egypt and returned to Israel on POD 8. Within the ensuing 4 weeks he experienced acute rejection which responded to treatment with steroids. Few days after discharge he was readmitted because of fever and graft dysfunction. An infected large perigraft collection was drained, but the patient became anuric and septic. Kidney biopsy showed infarcted necrotic tissue infiltrated by fungi which grew Mucur species. Despite initial improvement following graft nephrectomy and antifungal treatment the patient died of sepsis. Literature review revealed only three additional cases of graft infection due to Mucorales. We conclude that Renal graft infection due to Mucorales is an extremely rare and potentially lethal complication. Living unrelated donation in third world countries might be a possible risk factor. Fungal colonization may occur during transplantation. A high index of suspicion, leading to early diagnosis and initiation of antifungal treatment, in addition to graft nephrectomy, are keys to a more favorable outcome.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Case Reportmentioning

confidence: 99%

See 2 more Smart Citations

Mucormycosis of the renal allograft: case report and review of the literature

Chkhotua¹,

Yussim²,

Tovar³

et al. 2001

Transplant International

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“…Cutaneous aspergillosis among solid-organ transplant recipients usually occurs as primary infection directly in the surgical wound among liver or renal transplantation patients (33,35,43,50) or as nodules near a site of a break in the integument that is different from the primary surgical transplantation wound, most frequently among cardiac transplant recipients (24,28,36,59). Primary cutaneous aspergillosis in solid-organ transplant recipients generally occurs in the setting of a normal neutrophil count.…”

Section: Solid-organ Transplant Recipientsmentioning

confidence: 99%

Cutaneous aspergillosis

Estrada

Piérard-Franchimont²,

Soyeur-Broux³

et al.

SpringerReference

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Half‐sandwich ruthenium(II) and iridium(III) complexes of imidazole based phosphinite ligands: antioxidant and antibacterial activities as well as electrochemical properties

Işik,

Rafikova,

Meriç

et al. 2024

ChemistrySelect

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Ruthenium(II) and iridium(III) complexes of phosphinites including imidazole moiety were synthesized and characterized by microanalysis, IR, MS, and NMR spectroscopies. Antibacterial activity against Gram‐positive and Gram‐negative bacterial strains was assessed in all complexes. The highest radical scavenging (72.2 %) was obtained for [3‐(3‐chloro‐2‐({[dichloro(η6‐benzene)ruthenium]diphenylphosphanyl}oxy)propyl)‐1‐butyl‐1H‐imidazol‐3‐ium chloride], 4 at 200 μg/mL concentration, while [3‐(3‐chloro‐2‐({[dichloro(η5‐pentamethylcyclopentadienyl)‐iridium]diphenylphosphanyl}oxy)pro‐pyl)‐1‐butyl‐1H‐imidazol‐3‐ium chloride], 6 demonstrated the highest antibacterial activity as 13 mm inhibition zone against E. hirea. Furthermore, optical and electrochemical featured of metal complexes containing imidazole phosphinite were investigated utilizing UV–vis absorption and cyclic voltammetry techniques. Consequently, all complexes can be proposed as metal‐based charge convertible phosphinite complexes which may be employed as new generation and synergistic Dye‐Sensitized Solar Cell (DSSC) materials.

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Invasive fungal infections in renal transplant recipients

Cited by 111 publications

References 11 publications

Mucormycosis of the renal allograft: case report and review of the literature

Mucormycosis of the renal allograft: case report and review of the literature

Cutaneous aspergillosis

Half‐sandwich ruthenium(II) and iridium(III) complexes of imidazole based phosphinite ligands: antioxidant and antibacterial activities as well as electrochemical properties

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