Invasive Fungal Sinusitis by Lasiodiplodia theobromae in an Patient with Aplastic Anemia: An Extremely Rare Case Report and Literature Review

Gu, Hyun Jung; Kim, Young Jin; Lee, Hee Joo; Dong, Seok Ho; Kim, Sung Wan; Huh, Hee Jae; Ki, Chang‐Seok

doi:10.1007/s11046-016-0062-z

Cited by 5 publications

(1 citation statement)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Lasiodiplodia theobromae (order Botryosphaeriales ) is the only species of this genus involved in human opportunistic infections (41–46). Valenzuela-Lopez et al (6) found a higher species diversity in the North American study than we report here, since five of the French isolates were identified as L. theobromae .…”

Section: Discussionmentioning

confidence: 99%

Diversity of coelomycetous fungi in human infections: a 10-year experience of two European reference centres

García-Hermoso

Valenzuela-López

Rivero-Menéndez

et al. 2018

Preprint

View full text Add to dashboard Cite

25The coelomycetous fungi are difficult to properly identify from their phenotypic 26 characterization and their role as etiologic agents of human infections is not clear. We 27 studied the species distribution of these fungi among clinical isolates that had been 28 collected and stored over a ten-year period in two European reference laboratories 29 (France and Spain). We identified phenotypically and molecularly 97 isolates by 30 sequencing the D1-D2 fragment of the 28S nrRNA (LSU) gene. Species of the orders 31 Pleosporales and Glomerellales were present in both collections, and Botryosphaeriales 32 and Diaporthales only in the French one. The most prevalent species were Medicopsis 33 romeroi, Neocucurbitaria keratinophila, Neocucurbitaria unguis-hominis and 34 Paraconiothyrium cyclothyrioides, which had been recovered primarily from superficial 35 tissues. The Didymellaceae was the most common family represented, with 27 isolates 36 distributed into five genera. 37 38 40 41 Human infections by coelomycetous fungi are rare and poorly characterized due 42 to the difficulty in identifying these fungi using only phenotypic tools. The 43 coelomycetous fungi are characterized by the production of conidia into fruiting bodies 44 (= conidiomata), and were originally included in the orders Sphaeropsidales and 45 Melanconiales of the class Coelomycetes, taxa which today lack scientific validity due 46 to the demonstrated polyphyletic character of this sort of fungus (1-3). They cause 47 superficial or subcutaneous infections, mostly following a traumatic inoculation of 48 contaminated plant material or soil particles during agricultural work in tropical and 49 subtropical areas (4-6). The most common coelomycetous fungi involved in these 50 infections are the etiologic agents of black-grain eumycetoma, such as Biatriospora 51 mackinnonii; Falciformispora spp., Medicopsis romeroi, and 52 Pseudochaetosphaeronema larense. Other common coelomycetous fungi include 53 Lasiodiplodia theobromae and Neoscytalidium dimidiatum (synanamorph of 54 Hendersonula toruloidea) (7-11), which typically cause onychomycosis, subcutaneous 55 phaeohyphomycosis (12-15), and eumycetoma (16). In addition, many species of 56 Phoma and Pyrenochaeta have been reported as occasional agents of localized and 57 systemic infections in humans (9, 17-20). The taxonomy of several coelomycetous 58 genera mentioned before have been revised recently but they still constitute a group of 59 highly polyphyletic taxa that are usually difficult to identify phenotypically (2, 21-24). 60 In a recent study conducted in the USA, Valenzuela-Lopez et al. (6) identified 61 230 fungal strains by sequencing the D1-D2 domains of the 28S rRNA gene (LSU), 62 from which 152 (66.1%) strains belonged to the order Pleosporales, the rest being 63 distributed in several orders of the phylum Ascomycota. Most of these strains were 64 recovered from superficial tissue. Neoscytalidium dimidiatum, Paraconiothyrium 65 cyclothyrioides and members of the family Didymellaceae were the most...

show abstract

Section: Discussionmentioning

confidence: 99%

Diversity of coelomycetous fungi in human infections: a 10-year experience of two European reference centres

García-Hermoso

Valenzuela-López

Rivero-Menéndez

et al. 2018

Preprint

View full text Add to dashboard Cite

show abstract

Curvularia, Exophiala, Scedosporium, Sporothrix, and Other Melanized Fungi

Guarro,

Madrid,

de Hoog

2023

ClinMicroNow

View full text Add to dashboard Cite

This chapter covers most of the agents of phaeohyphomycosis, chromoblastomycosis, and sporotrichosis, as well as a number of agents of superficial and cutaneous disease. Pleoanamorphism is particularly striking in members of the black yeasts and in the genera Scedosporium and Triadelphia . Members of the genus Curvularia usually produce elongated conidia that are inconspicuously distoseptate and often possess an intermediate, asymmetrically swollen cell that gives the conidia a typically curved appearance. Exophiala is the main genus of clinically relevant black yeasts. Sporothrix brasiliensis is highly virulent and has caused large epidemics in Brazil; transmission occurs particularly through stray cats. Dematiaceous fungi are able to cause superficial infections, such as those of the skin and nails. Some melanized phialidic fungi were segregated from Phialophora on molecular and morphological grounds; these fungi now constitute small islands of clinical significance in the order Calosphaeriales, which otherwise contains plant‐associated moulds.

show abstract

Antifungal Susceptibility, Morphological and Molecular Characterization of Lasiodiplodia theobromae Isolated from a Patient with Keratitis

et al. 2018

View full text Add to dashboard Cite

Lasiodiplodia theobromae is a rare ocular pathogen. We report a patient with fungal keratitis caused by L. theobromae. The patient was a 75-year-old male, a farmer with diabetes type II, and no previous history of ocular trauma. Histopathology analysis revealed the presence fungi invading Descemet's membrane of the cornea. The fungus was characterized by septate, highly bulged fungal filaments involving full corneal thickness in the corresponding histopathology specimens. A dematiaceous mold was isolated and initally identified as L. theobromae by microscopic and macroscopic morphology, and further confirmed by PCR-based determination of internal transcribed spacer (ITS) regions of ribosomal DNA. Antifungal susceptibility tests showed sensitivity to amphotericin B (AMB) and voriconazole ( VRC), and resistance to other azoles, including itraconazole (ITC) and fluconazole (FLC). Corneal transplant was performed. Despite in vitro itraconazole resistance, the patient was successfully treated with oral itraconazole, topical voriconazole and natamycin, combined with ocular injections of amphotericin B and voriconazole.

show abstract

Invasive Fungal Sinusitis by Lasiodiplodia theobromae in an Patient with Aplastic Anemia: An Extremely Rare Case Report and Literature Review

Cited by 5 publications

References 33 publications

Diversity of coelomycetous fungi in human infections: a 10-year experience of two European reference centres

Diversity of coelomycetous fungi in human infections: a 10-year experience of two European reference centres

Curvularia, Exophiala, Scedosporium, Sporothrix, and Other Melanized Fungi

Antifungal Susceptibility, Morphological and Molecular Characterization of Lasiodiplodia theobromae Isolated from a Patient with Keratitis

Contact Info

Product

Resources

About