Invasive <i>Trichophyton rubrum</i> mimicking blastomycosis in a patient with solid organ transplant

Talebi‐Liasi, Faezeh; Shinohara, Michi M.

doi:10.1111/cup.12987

Cited by 9 publications

(4 citation statements)

References 13 publications

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“…This risk is well known for Fusarium spp. ( Varon et al, 2014 ) and has also been reported in cases of invasive infections by T. rubrum originating from onychomycosis ( Talebi-Liasi and Shinohara, 2017 ).…”

Section: Discussionmentioning

confidence: 80%

Propolis Extract for Onychomycosis Topical Treatment: From Bench to Clinic

et al. 2018

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Onychomycosis is a chronic fungal infection of nails, commonly caused by dermatophyte fungi, primarily species of Trichophyton. Because of the limited drug arsenal available to treat general fungal infections and the frequent failure of onychomycosis treatment, the search for new therapeutic sources is essential, and topical treatment with natural products for onychomycosis has been encouraged. Propolis, an adhesive resinous compound produced by honeybees (Apis mellifera), has shown multiple biological properties including significant antifungal and anti-biofilm activities in vitro. In spite of promising in vitro results, in vivo results have not been reported so far. This study assessed an ethanol propolis extract (PE) as a topical therapeutic option for onychomycosis, including its characterization in vitro and its applicability as a treatment for onychomycosis (from bench to clinic). The in vitro evaluation included analysis of the cytotoxicity and the antifungal activity against the planktonic cells and biofilm formed by Trichophyton spp. We also evaluated the capacity of PE to penetrate human nails. Patients with onychomycosis received topical PE treatments, with a 6-month follow-up period. The results of the in vitro assays showed that PE was non-toxic to the cell lines tested, and efficient against both the planktonic cells and the biofilm formed by Trichophyton spp. The results also showed that PE is able to penetrate the human nail. The results for PE applied topically to treat onychomycosis were promising, with complete mycological and clinical cure of onychomycosis in 56.25% of the patients. PE is an inexpensive commercially available option, easy to obtain and monitor. Our results indicated that PE is a promising natural compound for onychomycosis treatment, due to its ability to penetrate the nail without cytotoxicity, and its good antifungal performance against species such as Trichophyton spp. that are resistant to conventional antifungals, both in vitro and in patients.

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Section: Discussionmentioning

confidence: 80%

Propolis Extract for Onychomycosis Topical Treatment: From Bench to Clinic

et al. 2018

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“…Three prior case reports have illustrated T rubrum infection mimicking Blastomyces, with sporelike shapes and pseudobudding on histological findings. [3][4][5] This ambiguity in fungal morphology reaffirms the importance of verifying organism classification through polymerase chain reaction or fungal culture to ensure appropriate therapy and systemic evaluation.…”

Section: Discussionmentioning

confidence: 97%

Erythematous Plaque Studded With Papules and Pustules in an Immunocompetent Patient

Shahin,

Idriss,

Lehman

2024

JAMA Dermatol

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“…Less than 100 cases of invasive T. rubrum have been reported in the literature since its description by Majocchi et al in 1883. 2 The disease has 4 distinct clinical manifestations: Majocchi granuloma, deep dermatophytosis, disseminated dermatophytosis, and (pseudo)mycetoma (Table I). In the context of immunosuppression and active tinea without systemic antifungal treatment, it is likely that our patient insidiously progressed from superficial to superimposed deep dermatophytosis while being treated for HS.…”

Section: Discussionmentioning

confidence: 99%

“…Histologically, pleomorphic features including chlamydoconidium, arthroconidium, pseudobudding, branching hyphae, and broad-based budding have been reported in this population, suggesting a broad variety of possible fungal infections. 2,5,6 Tissue section plane, hyphal orientation, and tissue viability also influence the histological appearance of these structures. 7 Therefore, polymerase chain reaction or culture are often required to determine the causative organism.…”

Section: Discussionmentioning

confidence: 99%