Invasive <i>Campylobacter jejuni/coli </i>Infections：9 Case Reports at a Single Center between 2000 and 2015, and a Review of Literature Describing Japanese Patients

Emergence of Carbapenem Non-susceptible <i>Campylobacter coli</i> after Long-term Treatment against Recurrent Bacteremia in a Patient with X-linked Agammaglobulinemia

“…remain susceptible to a range of antibiotics ( 6 ), but strains resistant to third-generation cephalosporins, macrolides, and fluoroquinolones have been increasingly reported ( 14 - 16 ). Carbapenem is recommended as an empiric agent for Campylobacter bacteremia ( 7 , 10 , 17 , 18 ); however, the causative organism in the present case demonstrated an increasing MIC level for meropenem after the prolonged antibiotic therapy. In Japan, the recommended dose of tebipenem is 4 to 6 mg/kg twice daily for children, while the optimum dose for adults is not described on the drug package insert.…”

“…The clinical manifestations of C. coli bacteremia have only rarely been reported. Previous studies have shown that patients with immunocompromising factors, like our patient, tend to suffer from recurrent C. coli bacteremia without gastrointestinal symptoms ( 7 , 31 ). Cutaneous involvement is less recognized and may often be overlooked as a presentation of Campylobacter bacteremia ( 32 ).…”

“…Among Campylobacter spp., Campylobacter coli is the second-most frequent pathogen of community-onset Campylobacter infection, followed by Campylobacter jejuni ( 1 ). Based on previous reports, usually less than 1% of C. coli infections are complicated with bacteremia ( 2 - 7 ). However, the incidence of systemic infection with C. coli might be underestimated due to its slow growth and the infrequency of blood culture examinations for outpatients with enterocolitis ( 8 , 9 ).…”

There's not always one enemy: Co‐infection of campylobacter jejuni and non‐typhoidal salmonella in a patient with systemic lupus erythematosus

“…Choosing the optimal antimicrobial therapy for treating Campylobacter jejuni bacteremia can be difficult owing to the lack of high‐quality evidence based on studies comparing the efficacy of various treatments. A variety of antimicrobial treatments are used, including ampicillin, ceftriaxone, ciprofloxacin, levofloxacin, meropenem, erythromycin, azithromycin, and fosfomycin, and a standardized treatment period has not been established because some cases of transient bacteremia resolve without treatment.. 4 , 7 Reports of past treatments have shown a considerable variation in the duration of treatment (4–19 days) and choice of antimicrobial agents. Many, previous patients were not treated with macrolides.…”

“…Many, previous patients were not treated with macrolides. 7 , 8 Among those that were, one received erythromycin for 12 days. 8 …”