Invasive micropapillary urothelial carcinoma of the bladder

López-Beltrán, Antonio; Montironi, Rodolfo; Blanca, Ana; Liu, Cheng

doi:10.1016/j.humpath.2009.11.018

Cited by 73 publications

(42 citation statements)

References 23 publications

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“…[1][2][3] Several studies demonstrated that micropapillary urothelial carcinoma is diagnosed at a more advanced stage, and is associated with adverse outcome relative to typical urothelial carcinoma. [4][5][6][7][8] However, a recent study found that, although patients with micropapillary urothelial carcinoma presented at higher stage than patients with typical urothelial carcinoma, the outcomes following radical cystectomy were no different when matched for stage and other clinicopathologic variables. 9 In addition to unique histologic features, studies have shown that micropapillary urothelial carcinoma exhibits amplification of the human epidermal growth factor receptor (ERBB2 or HER2) in over 40% of cases.…”

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confidence: 99%

Outcome of patients with micropapillary urothelial carcinoma following radical cystectomy: ERBB2 (HER2) amplification identifies patients with poor outcome

et al. 2014

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Micropapillary urothelial carcinoma exhibits amplification of the human epidermal growth factor receptor, ERBB2(HER2), and overexpression of the ERBB2 protein product. The clinical significance of this has yet to be established. The objective of this study was to examine ERBB2 amplification and protein expression in micropapillary urothelial carcinoma and stage-matched typical urothelial carcinoma treated by radical cystectomy to assess the frequency of amplification and protein expression, and to determine the association with cancer-specific survival. Pathologic material and data from patients undergoing cystectomy at Mayo Clinic between 1980 and 2008 were reviewed. ERBB2 amplification by fluorescence in situ hybridization (FISH) and protein expression by immunohistochemistry were assessed. Univariate and multivariate Cox proportional hazards regression models were used to evaluate for associations of ERBB2 amplification and protein expression with survival. ERBB2 amplification was identified in 9 (15%) of 61 micropapillary carcinomas compared with 9 (9%) of 100 urothelial carcinomas. In patients with micropapillary carcinoma, ERBB2 amplification was associated with a nearly threefold increased risk of cancer death. ERBB2 amplification (hazard ratio 4.3; P ¼ 0.0008) remained associated with an increased risk of death from bladder cancer among patients with micropapillary urothelial carcinoma on multivariate analysis. The association of cancer-specific survival and ERBB2 amplification was not seen in patients with urothelial carcinoma. ERBB2 immunohistochemistry correlated with ERBB2 amplification but there was no association of ERBB2 protein expression and survival. ERBB2 amplification is more frequent in micropapillary urothelial carcinoma than typical urothelial carcinoma, and patients with micropapillary carcinoma who have ERBB2 amplification have worse cancer-specific survival than those who do not. Identification of ERBB2 amplification in micropapillary carcinoma could provide important prognostic information and possibly provide a role for ERBB2 targeted therapy.

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confidence: 99%

Outcome of patients with micropapillary urothelial carcinoma following radical cystectomy: ERBB2 (HER2) amplification identifies patients with poor outcome

et al. 2014

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“…Histological diagnosis was established according to classic descriptions [1,2,3] and more recently published data [17]. As stated before, only those tumors showing >50% of micropapillary growth pattern were selected.…”

Section: Resultsmentioning

confidence: 99%

“…Since then, different studies have confirmed its aggressive behavior, and early cystectomy has been proposed for these patients [2,3,4]. The micropapillary growth pattern shown by this tumor is characterized by tumoral nests with inverse cell polarity and a characteristic retraction or cleft from the surrounding connective stroma [5].…”

Section: Introductionmentioning

confidence: 99%

Micropapillary Carcinoma of the Urinary Tract: A Cytologic Study of Urine and Fine-Needle Aspirate Samples

et al. 2014

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Objective: Micropapillary carcinoma (MPC) is an aggressive variant of urothelial carcinoma that needs early and specific recognition. In order to determine whether this tumor variant can be recognized with cytology, we evaluated a large cytohistological series. Study Design: It was a retrospective cytohistological correlation study including 20 patients with MPC. Only those cases in which the tumor exhibited >50% of micropapillary growth were selected. Twenty exfoliative urine specimens and four needle aspirates from lymph node metastases were reviewed. Results: On histology, 14 cases were infiltrative, while 6 were exclusively superficial. Cytology was characterized by numerous small, cohesive groups and single neoplastic cells. Pseudopapillae were present in 17 cases and in 9 they were a relevant finding. Morules were present in 15 cases. Isolated microacini were seen in 14 cases. Infiltrative tumors showed more neoplastic groups. Cellular atypia was prominent in 17 cases. In 15 cases, a cytologic diagnosis of urothelial carcinoma was made. One case was diagnosed as adenocarcinoma. The remaining 4 cases were considered suspicious of malignancy. Conclusions: The peculiar morphology of MPC of the urinary tract is partially reflected on cytology, allowing in some cases a specific recognition. This is important since the aggressive behavior of this neoplasm needs rapid management and treatment.

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“…Carcinoma in situ (CIS) and lymphovascular invasion were observed in 3/4 (75%) biopsies [29] with micropapillary features (Figure 1). Notably these three patients had smoked for more than 10 years.…”

Section: Page 3 Ofmentioning

confidence: 99%

Urinary Thrombomodulin Levels Were Significantly Higher Following Occupational Exposure to Chemicals, In The Presence of Dipstick Protein, But Not in the Presence of Dipstick Blood

Ruddock

Simoes²,

O’Rourke

et al. 2016

Biol Med (Aligarh)

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Invasive micropapillary urothelial carcinoma of the bladder

Cited by 73 publications

References 23 publications

Outcome of patients with micropapillary urothelial carcinoma following radical cystectomy: ERBB2 (HER2) amplification identifies patients with poor outcome

Outcome of patients with micropapillary urothelial carcinoma following radical cystectomy: ERBB2 (HER2) amplification identifies patients with poor outcome

Micropapillary Carcinoma of the Urinary Tract: A Cytologic Study of Urine and Fine-Needle Aspirate Samples

Urinary Thrombomodulin Levels Were Significantly Higher Following Occupational Exposure to Chemicals, In The Presence of Dipstick Protein, But Not in the Presence of Dipstick Blood

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