Invasive mucinous adenocarcinoma misdiagnosed as pneumonia: A case report

Abstract

Common imaging findings of invasive mucinous adenocarcinoma (IMA) include consolidation of the lung parenchyma, nodules, and ground-glass changes. However, the IMA imaging findings in the present case included diffuse, patchy and blurry density shadows through both lungs. To the best of the authors' knowledge, this image pattern has rarely been reported. The patient provided his consent and authorized the publication of photographs featuring his likeness. The present study reported a patient was diagnosed with IMA via pathologic and genetic analyses. Following antibiotic treatment, the lesions in both sides became larger. Further examinations were completed and IMA was confirmed by biopsy pathohistological examination. Pathological specimens were negative for almost all driver genes mutations, except KRAS. The patients and family refused further treatment, including chemotherapy, radiotherapy and interventional chemotherapy and the patient was discharged from The First Affiliated Hospital of Chengdu Medical College. The present case report emphasized that IMA should be suspected when imaging studies show diffuse lesions throughout both lungs. When a patient does not respond to treatment, clinicians should consider alternative diagnoses.

Efficacy of phentolamine combined with milrinone on severe pneumonia in children, and its effect on serum levels of MMP-9, TIMP-1 and sICAM-1

“…The World Health Organization (WHO) estimates that the vast majority (over 95 %) of the estimated 156 million pneumonia incidents in young children each year occurs in developing countries. [6] Globally, South Asia and sub-Saharan Africa had the highest rates of pneumonia; 15 countries in these two regions alone accounted for more than two-thirds of pneumonia deaths in 2011 [7].…”

“…Nonetheless, community-acquired pneumonia remains a major cause of high morbidity and mortality in children [6][7][8]. Specifically, there are an estimated 327,000 cases and 12,000 -28,000 deaths each year due to pneumonia in children [6]. Hospital-based research helps understand the causes of pneumonia in developing countries.…”

“…It improves myocardial contractility, accelerates vasodilation, reduces vascular resistance, and effectively alleviates clinical symptoms and signs in patients with pneumonia. However, the duration of this effect is short [4][5][6]. Children with severe pneumonia often experience compromised heart function.…”

Natural compounds targeting cellular redox homeostasis in malignancies

“…Natural compounds can inhibit tumor growth by promoting apoptosis of tumor cells, with a potential for tumor angiogenesis and reducing tumor cell resistance, extending patient survival, improving clinical symptoms, and raising patients' quality of life. For instance, triterpenoid compounds (TCs) possess good antioxidant and antitumor activities (13). The TCs obtained from Morchella mycelium significantly suppressed the proliferation of PC-3, HT-29, HepG2, HeLa, and HepG2 cell lines (14).…”