Invasive Multiple Supraglottic Squamous Cell Papillary Carcinoma in an Adult

Abstract

Invasive papillary squamous cell carcinoma of the supraglottic larynx is described in an adult male. The clinicopathological appearance was that of a multiple growth which displayed various gradients of neoplastic changes: in situ, microinvasion, frank invasion of cartilage and cervical node metastases. No previous history of radiotherapy was elicited. The growth was excised by supraglottic laryngectomy and neck dissection. Typical metastatic papillary formations were observed in lymph nodes.

Review Article: Relationship of Human Papillomavirus With Papillary Squamous Cell Carcinoma of the Upper Aerodigestive Tract: A Review

“…The diagnosis of PSCC was established on the basis of histological features. In 8 cases (5 cases in Cardesa et al, 5 1 case in Ereño et al, 13 1 case in Shanon et al, 14 and 1 case in Judd et al 16 ), papillary carcinoma with microinvasion or infiltration of the submucosal tissue was observed. In the majority of patients, cytopathic effect was not observed in the biopsy specimens.…”

“…8 The analysis of age shows that the majority of patients were on average more than 50 years of age. 3,7,8 The most common site involved was the larynx (3 cases in Cardesa et al, 5 17 cases in Suarez et al, 8 1 case in Ereño et al, 13 and 1 case in Shanon et al 14 ), followed by the alveolar ridge (20 cases in Ishiyama et al 3 ). The other sites affected were buccal mucosa (13 cases in Ishiyama et al 3 and 2 cases in Takeda et al 15 ), sinonasal tract (11 cases in Suarez et al 8 and 1 case in Judd et al 16 ), nasopharynx, 5 and oropharynx.…”

“…Major predisposing factors included being a smoker (27 cases in Ishiyama et al, 3 1 case in Cardesa et al, 5 10 cases in Thompson et al, 7 and 1 case in Shanon et al 14 ) and alcohol abuse (8 cases in Ishiyama et al, 3 3 cases in Cardesa et al, 5 5 cases in Thompson et al, 7 and 1 case in Shanon et al 14 ), although there is no strong relation of alcohol and tobacco consumption in the common squamous cell carcinoma cases. 18 In 1 case, 5 there was previous squamous cell carcinoma in the glottis.…”

Human Papillomavirus Associated with Papillary Squamous Cell Carcinoma of the Oropharynx in a Renal Transplant Recipient

“…The tumor is an entity, with few cases published in the literature, which is mainly located in the supraglotic region [4,5]. Like the rest of HNSCC, a relationship between PSCC with HPV infection has been published recently [6].…”

Papillary squamous cell carcinoma of the larynx

“…One of the rst mentions of a papillary tumour in this region was made in the sixties by Parkhill, 3 who described a papillary tumour in the palatine tonsil. More recently, Shano et al 4 reported an invasive and metastasizing PSCC of the supraglottic larynx.…”