Invasive Neisseria meningitidis Strain Expressing Capsular Polysaccharides W and Y in Brazil

Barroso, David E.; Castiñeiras, Terezinha Marta Pereira Pinto; Rebelo, Maria Cristina; Tulenko, Mary M.; Marsh, Jane W.; Krauland, Mary G.; Harrison, Lee H.

doi:10.1128/jcm.02787-12

Cited by 2 publications

(1 citation statement)

References 11 publications

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“…Three of the isolates serogrouped as MenW, with fine type P1.5-2, 10-1, F4-1, sequence type 23 (ST-23) (CC23), were confirmed to contain a mutation in the amino acid at position 310 of the capsule polymerase enzyme csy that led to a change of glycine (serogroup Y) or proline (serogroup W) to serine, enabling expression of a mixed galactose/glucose-sialic acid polysaccharide. Because these isolates thus belong to serogroup W/Y ( 31 – 33 ), they were excluded from further analyses.…”

Section: Resultsmentioning

confidence: 99%

Whole-Genome Sequencing of Emerging Invasive Neisseria meningitidis Serogroup W in Sweden

et al. 2018

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Invasive disease caused by Neisseria meningitidis serogroup W (MenW) has historically had a low incidence in Sweden, with an average incidence of 0.03 case/100,000 population from 1995 to 2014. In recent years, a significant increase in the incidence of MenW has been noted in Sweden, to an average incidence of 0.15 case/100,000 population in 2015 to 2016. In 2017 (1 January to 30 June), 33% of invasive meningococcal disease cases (7/21 cases) were caused by MenW. In the present study, all invasive MenW isolates from Sweden collected in 1995 to June 2017 (n = 86) were subjected to whole-genome sequencing to determine the population structure and to compare isolates from Sweden with historical and international cases. The increase of MenW in Sweden was determined to be due to isolates belonging to the South American sublineage of MenW clonal complex 11, namely, the novel U.K. 2013 lineage. This lineage was introduced in Sweden in 2013 and has since been the dominant lineage of MenW.

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Section: Resultsmentioning

confidence: 99%