Invasive Neuromonitoring Modalities in the Pediatric Population

Lang, Shih-Shan; Rahman, Raphia; Kumar, Nankee; Tucker, Alexander M.; Flanders, Tracy M.; Kirschen, Matthew; Huh, Jimmy W.

doi:10.1007/s12028-023-01684-7

Cited by 6 publications

(1 citation statement)

References 153 publications

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“…Although invasive multimodality neuromonitoring is most commonly used in patients after traumatic brain injury (TBI), it has been successfully employed in acute nontraumatic neurologic conditions causing cerebral edema in adults and children (1–3). Importantly, elevated ICP and low Pbt o 2 have been shown to occur exclusive of one another and are independently associated with poor outcomes (1, 4–6). To our knowledge, there have been no prior reports of invasive multimodality neuromonitoring used to guide management of elevated ICP and brain tissue hypoxia in MOGAD.…”

Section: Introductionmentioning

confidence: 99%

Invasive Multimodality Neuromonitoring to Manage Cerebral Edema in Pediatric Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease

Fainberg,

Silver,

Arena

et al. 2023

Critical Care Explorations

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Background: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an inflammatory disorder of the CNS with a variety of clinical manifestations, including cerebral edema. Case Summary: A 7-year-old boy presented with headaches, nausea, and somnolence. He was found to have cerebral edema that progressed to brainstem herniation. Invasive multimodality neuromonitoring was initiated to guide management of intracranial hypertension and cerebral hypoxia while he received empiric therapies for neuroinflammation. Workup revealed serum myelin oligodendrocyte glycoprotein antibodies. He survived with a favorable neurologic outcome. Conclusion: We describe a child who presented with cerebral edema and was ultimately diagnosed with MOGAD. Much of his management was guided using data from invasive multimodality neuromonitoring. Invasive multimodality neuromonitoring may have utility in managing life-threatening cerebral edema due to neuroinflammation.

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Section: Introductionmentioning

confidence: 99%