Invasive NontypeableHaemophilus influenzaeInfection Among Adults With HIV in Metropolitan Atlanta, Georgia, 2008-2018

Abstract

influenzae (NTHi) infection among adults is typically associated with bacteremic pneumonia. Nontypeable H influenzae is genetically diverse and clusters of infection are uncommon. OBJECTIVE To evaluate an increase in invasive NTHi infection from 2017-2018 among HIV-infected men who have sex with men in metropolitan Atlanta, Georgia. DESIGN, SETTING, AND PARTICIPANTS A population-based surveillance study with a cohort substudy and descriptive epidemiological analysis identified adults aged 18 years or older with invasive NTHi infection (isolation of NTHi from a normally sterile site) between January 1, 2008, and December 31, 2018 (final date of follow-up). EXPOSURES Time period, HIV status, and genetic relatedness (ie, cluster status) of available NTHi isolates.

Invasive Haemophilus influenzae Infections after 3 Decades of Hib Protein Conjugate Vaccine Use

“…(i) Invasive H. influenzae disease and HIV. From 2017 to 2018, invasive NTHi infections in HIV-infected men who had sex with men increased in metropolitan Atlanta, Georgia (72). The incidence of invasive NTHi infection in HIV-positive individuals (41.7/ 100,000) in 2017 to 2018 was significantly greater than that in HIV-positive individuals from 2008 to 2016 (9.9/100,000; P , 0.001) and in those without HIV from 2008 to 2018 (1.1/100,000; P , 0.001).…”

A Rare Case of HIV-Induced Neutropenia Resulting in Haemophilus influenzae Septic Oligoarthritis: A Case-Based Literature Review

“…For H. influenzae to infect a joint, the patient either did not receive a vaccination or, more likely, they are immunocompromised. Interestingly, there was a documented increase in cases of invasive H. influenzae infections in HIV patients in Atlanta, Georgia between 2008 and 2018, where 553 cases of invasive H. influenzae were found, but not specifically of septic arthritis [ 6 ]. We report a case where H. influenzae infects multiple joints in an individual diagnosed with HIV.…”

Molecular Epidemiology of Contemporary Invasive Haemophilus influenzae Isolates in Texas Children

“…Additionally, there is some evidence that select sequence types (STs) may be associated with specific infectious diagnoses. 6…”