Invasive Pneumococcal Disease among Adults: Associations among Serotypes, Disease Characteristics, and Outcome

Jansen, Angelique G S C; Rodenburg, Gerwin D.; Ende, Arie van der; Alphen, Loek van; Veenhoven, Reinier H.; Spanjaard, Lodewijk; Sanders, Elisabeth A. M.; Hak, Eelko

doi:10.1086/600045

Cited by 141 publications

(124 citation statements)

References 13 publications

Supporting

Mentioning

101

Contrasting

Unclassified

Order By: Relevance

“…This serotype-specifi c difference in disease potential has also been shown for mucosal infections, although the differences between serotypes were less apparent compared with differences in invasive potential (33). In addition, serotypes are independently associated with IPD severity (34,35). Harboe et al showed that highly encapsulated and frequently carried serotypes such as 11A, 10A, and 19A have high mortality rates among healthy persons >5 years of age that are comparable to PCV7 serotypes such as 19F or 6B.…”

Section: Discussionmentioning

confidence: 75%

Carriage ofStreptococcus pneumoniae3 Years after Start of Vaccination Program, the Netherlands

Spijkerman¹,

Gils²,

Veenhoven³

et al. 2011

Emerg. Infect. Dis.

Self Cite

View full text Add to dashboard Cite

To evaluate the effectiveness of the 7-valent pneumococcal conjugate vaccine (PCV7) program, we conducted a cross-sectional observational study on nasopharyngeal carriage of Streptococcus pneumoniae 3 years after implementation of the program in the Netherlands. We compared pneumococcal serotypes in 329 prebooster 11-month-old children, 330 fully vaccinated 24-month-old children, and 324 parents with age-matched pre-PCV7 (unvaccinated) controls (ages 12 and 24 months, n = 319 and n = 321, respectively) and 296 of their parents. PCV7 serotype prevalences before and after PCV7 implementation, respectively, were 38% and 8% among 11-month-old children, 36% and 4% among 24-monthold children, and 8% and 1% among parents. Non-PCV7 serotype prevalences were 29% and 39% among 11-monthold children, 30% and 45% among 24-month-old children, and 8% and 15% among parents, respectively; serotypes 11A and 19A were most frequently isolated. PCV7 serotypes were largely replaced by non-PCV7 serotypes. Disappearance of PCV7 serotypes in parents suggests strong transmission reduction through vaccination.

show abstract

Section: Discussionmentioning

confidence: 75%

Carriage ofStreptococcus pneumoniae3 Years after Start of Vaccination Program, the Netherlands

Spijkerman¹,

Gils²,

Veenhoven³

et al. 2011

Emerg. Infect. Dis.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The reported estimated mortality associated with invasive pneumococcal disease varies from 7 to 43%, depending on pneumococcal serotype, medical history of the patient, and many other factors (2,12,14). Community-acquired pneumonia (CAP) is one of the most common causes of death worldwide and the leading cause of death by infection in the United States (9,13,19).…”

mentioning

confidence: 99%

Longitudinal Analysis of Pneumococcal Antibodies during Community-Acquired Pneumonia Reveals a Much Higher Involvement of Streptococcus pneumoniae than Estimated by Conventional Methods Alone

Mens

Meijvis

Endeman

et al. 2011

Clin. Vaccine Immunol.

View full text Add to dashboard Cite

“…The capsular polysaccharide of S. pneumoniae is known to be an important factor in the pathogenicity of the organism (7), and associations of the capsular serotypes with the severity of invasive pneumococcal diseases (IPDs) have been described (2,14). IPDs are known to be much more frequent among young children and elderly persons than among older children and middle-aged adults (25).…”

mentioning

confidence: 99%

Association of Serotypes of Streptococcus pneumoniae with Age in Invasive Pneumococcal Disease

Imöhl¹,

Reinert²,

Ocklenburg

et al. 2010

J Clin Microbiol

View full text Add to dashboard Cite

A total of 7,764 isolates from patients with invasive pneumococcal disease (IPD) were collected from 1992 to June 2006. Data on serotypes were available for 5,022 isolates (64.7% of all invasive isolates). Some 54.0% of the isolates originated from adults >16 years of age, and 46.0% were from children <16 years of age. The leading serotypes were 14, 23F, 1, 6B, 7F, 3, and 4. The serotypes significantly more common in children were 14, 6B, 19F, and 18C, while among adults, serotypes 3 and 4 were predominant. Serotype 7F was statistically more prevalent among children <4 months old than among the other age groups. Among children aged >4 months and <1 year, serotype 19F occurred statistically more frequently; and among children aged >1 year to <5 years, serotypes 14, 6B, and 18C were overrepresented. The serotypes predominantly affecting patients younger than the remaining collective of patients were 14, 6B, 19F, and 18C, while patients with IPD caused by serotypes 3, 4, and 9V were older than the collective, on average.Streptococcus pneumoniae is among the most important pathogens in bacterial pneumonia, sepsis, and meningitis worldwide (1). The capsular polysaccharide of S. pneumoniae is known to be an important factor in the pathogenicity of the organism (7), and associations of the capsular serotypes with the severity of invasive pneumococcal diseases (IPDs) have been described (2,14). IPDs are known to be much more frequent among young children and elderly persons than among older children and middle-aged adults (25). The results of several studies of the frequencies of pneumococcal serotypes and pneumococcal vaccine coverage have been published, but only few data on the serotype distribution among children and adults or different age groups are available. Studies from the United States (10,19,25), Canada (18), England and Wales (21), and Denmark (9), as well as the available meta-analyses (4, 15), refer to a diversity of age intervals. Although some studies contain statistics on the serotypes covered by the seven-valent pneumococcal conjugate vaccine (PCV7) and those not covered by the vaccine, no information on the association of individual serotypes with age are given. Another meta-analysis reported on the relative risk (odds ratio) of IPD caused by the various serotypes among all age groups subdivided into 10-year bands (26). Furthermore, in a 19-year nationwide surveillance study from Denmark, statistical analyses of the serotype distribution with age have been performed, but that study included only children aged 0 to 6 years (16). Some statistical data about individual serotypes and their association with age can also be found in the report of a study from the United States on the increased prevalence of pediatric pneumococcal serotypes in elderly adults. However, the study contained data only for adults aged Ն35 years (5).The aim of the study described here was to evaluate the association of serotypes of S. pneumoniae with age in IPD among isolates from all age groups sent to the German National Refere...

show abstract

Invasive Pneumococcal Disease among Adults: Associations among Serotypes, Disease Characteristics, and Outcome

Abstract: The serotype appeared to be independently associated with IPD severity in adults, which indicates that careful monitoring of IPD after implementation of conjugate vaccines is necessary.

Cited by 141 publications

References 13 publications

Carriage ofStreptococcus pneumoniae3 Years after Start of Vaccination Program, the Netherlands

Carriage ofStreptococcus pneumoniae3 Years after Start of Vaccination Program, the Netherlands

Longitudinal Analysis of Pneumococcal Antibodies during Community-Acquired Pneumonia Reveals a Much Higher Involvement of Streptococcus pneumoniae than Estimated by Conventional Methods Alone

Association of Serotypes of Streptococcus pneumoniae with Age in Invasive Pneumococcal Disease

Contact Info

Product

Resources

About