Invasive Pneumococcal Disease Characterization in Adults and Subgroups aged &lt; 60 years and ≥ 60 years in Bogota, Colombia

Leal, Aura Lucía; Moreno, Germán Camacho; Montañez-Ayala, Anita; Varón-Vega, Fabio Andrés; Alvarez-Rodríguez, José Camilo; Valderrama-Beltrán, Sandra; Ariza, Beatriz; Pancha, Oscar; Santana, Ana Yadira; Flórez, Nella Sánchez; Reyes, Patricia; Ruiz, Jaimé; Beltran, C; Prieto, E.; Rojas, Monica; Urrego-Reyes, Juan; Parellada, C.

doi:10.1016/j.ijregi.2022.04.007

Cited by 4 publications

(3 citation statements)

References 43 publications

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“…In children between 5-14 years of age, a decrease in PDs due to PCV10 serotypes was observed from 60% in 2012 to 8% in 2018 45 . In contrast, in children over 14 years of age and adults, no significant decrease in PCV10 serotypes has been demonstrated 35,45,46 (Figure 4).…”

Section: Pcv10 Effects On the Serotypes Included In Its Formulationmentioning

confidence: 90%

“…In 2021 the serotypes 3, 6A and 19A were 40% in adults over 60 years of age. A study in adults showed that the predominant serotypes were 19A and 3 24,44,46 . A study carried out in Bogotá, with the aim of determining which pneumococcal serotypes isolated in IPDs were associated with major cardiovascular events (MACE) in the adult population, found that serotype 19A was the most frequent (13%) and that 21% of patients with this serotype developed MACE.…”

Section: Pcv10 Effects On the Emergence Of Serotypes 3 6a 19amentioning

confidence: 99%

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Pneumococcal Diseases in Colombia: Epidemiological Analysis Before and During the Universal Children Immunization against Streptococcus pneumoniae in the Light of a Vaccine Change in 2022

Torres-Martínez,

Camacho-Moreno,

Patiño-Niño

et al. 2024

Infect

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Streptococcus pneumoniae causes meningitis, pneumonia and bacteremia, mainly in children under 5 years of age and in the elderly. Pneumococcal conjugate vaccines (PCVs) have been administered globally since the year 2000, contributing to substantially reduce the incidence of pneumococcal diseases (PDs). In 2012, Colombia implemented universal vaccination with PCV10 in children under 2 years of age, achieving a decrease and stabilization of the incidence of PDs. However, since 2014, replacement of vaccine serotypes by non-vaccine serotypes, such as 3 and 19A, predominantly, has been observed. Likewise, in 2019, there was an increase in the incidence of meningitis, coinciding with the increase of multi-resistant 19A clones. In July 2022, the vaccine formulation was changed to PCV13, which also has the potential to control serotypes 3, 6A, and 19A. This paper reviews the epidemiology of pneumococcus in Colombia, before and during the universal PCV10 vaccination.

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Section: Pcv10 Effects On the Serotypes Included In Its Formulationmentioning

confidence: 90%

Section: Pcv10 Effects On the Emergence Of Serotypes 3 6a 19amentioning

confidence: 99%

Pneumococcal Diseases in Colombia: Epidemiological Analysis Before and During the Universal Children Immunization against Streptococcus pneumoniae in the Light of a Vaccine Change in 2022

Torres-Martínez,

Camacho-Moreno,

Patiño-Niño

et al. 2024

Infect

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“…The phenomenon of natural transformation was first discovered in Streptococcus pneumoniae ( 10 ), and in 1944, Avery et al ( 11 ) first proved that DNA is the carrier of genetic information via the natural transformation of S. pneumoniae . S. pneumoniae is a commonly encountered Gram-positive bacterial pathogen, and infections can result in lobar pneumonia, tracheitis, otitis media, meningitis, and septicemia ( 12 – 14 ). Approximately 1.6 million people succumb to these infections each year ( 15 ).…”

Section: Introductionmentioning

confidence: 99%

comCDE (Competence) Operon Is Regulated by CcpA in Streptococcus pneumoniae D39

Zhang

Zhang²,

Xiao

et al. 2023

Microbiol Spectr

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Invasive pneumococcal disease in Latin America and the Caribbean: Serotype distribution, disease burden, and impact of vaccination. A systematic review and meta-analysis

Bardach,

Ruvinsky,

Palermo

et al. 2024

PLoS ONE

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Background Invasive pneumococcal diseases (IPD) are associated with high morbidity, mortality, and health costs worldwide, particularly in Latin America and the Caribbean (LAC). Surveillance about the distribution of serotypes causing IPD and the impact of pneumococcal vaccination is an important epidemiological tool to monitor disease activity trends, inform public health decision-making, and implement relevant prevention and control measures. Objectives To estimate the serotype distribution for IPD and the related disease burden in LAC before, during, and after implementing the pneumococcal vaccine immunization program in LAC. Methods Systematic literature review following Cochrane methods of studies from LAC. We evaluated the impact of the pneumococcal vaccine on hospitalization and death during or after hospitalizations due to pneumococcal disease and serotype-specific disease over time. We also analyzed the incidence of serotyped IPD in pneumococcal conjugate vaccine PCV10 and PCV13. The protocol was registered in PROSPERO (ID: CRD42023392097). Results 155 epidemiological studies were screened and provided epidemiological data on IPD. Meta-analysis of invasive diseases in children <5 years old found that 57%-65% of causative serotypes were included in PCV10 and 66%-84% in PCV13. After PCV introduction, vaccine serotypes declined in IPD, and the emergence of non-vaccine serotypes varied by country. Conclusions Pneumococcal conjugate vaccines significantly reduced IPD and shifted serotype distribution in Latin America and the Caribbean. PCV10/PCV13 covered 57–84% of serotypes in children under 5, with marked decline in PCV serotypes post-vaccination. Continuous surveillance remains crucial for monitoring evolving serotypes and informing public health action.

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Invasive Pneumococcal Disease Characterization in Adults and Subgroups aged < 60 years and ≥ 60 years in Bogota, Colombia

Cited by 4 publications

References 43 publications

Pneumococcal Diseases in Colombia: Epidemiological Analysis Before and During the Universal Children Immunization against Streptococcus pneumoniae in the Light of a Vaccine Change in 2022

Pneumococcal Diseases in Colombia: Epidemiological Analysis Before and During the Universal Children Immunization against Streptococcus pneumoniae in the Light of a Vaccine Change in 2022

comCDE (Competence) Operon Is Regulated by CcpA in Streptococcus pneumoniae D39

Invasive pneumococcal disease in Latin America and the Caribbean: Serotype distribution, disease burden, and impact of vaccination. A systematic review and meta-analysis

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