Invasive pulmonary aspergillosis complicating allergic bronchopulmonary aspergillosis

Ganassini, A.; Cazzadori, Angelo

doi:10.1016/0954-6111(95)90198-1

Cited by 34 publications

(19 citation statements)

References 13 publications

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“…Furthermore, patients with mild ABPA may have abnormal serological markers without suggestive CT features [23]. ABPA may be associated with an increased risk of invasive aspergillosis, especially when treated with corticosteroids [24]. In the present study, cases with NTM compared to controls had an increased rate of clinical and serological evidence of ABPA; however, this was not statistically significant.…”

Section: Discussioncontrasting

confidence: 64%

Nontuberculous mycobacterial disease and Aspergillus-related lung disease in bronchiectasis

Kunst

Wickremasinghe²,

Wells³

et al. 2006

Eur Respir J

125

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The aim of the present study was to determine whether patients with bronchiectasis and nontuberculous mycobacteria (NTM) have a higher prevalence of Aspergillus-related lung disease.A series of 30 consecutive patients with bronchiectasis and NTM (cases) were compared with 61 patients with bronchiectasis and no evidence of NTM (controls). Aspergillus serology and computerised tomography of the thorax were used to identify Aspergillus-related lung diseases, including aspergilloma, allergic bronchopulmonary aspergillosis and chronic necrotising pulmonary aspergillosis.The rate of positive Aspergillus serology was higher in cases with NTM disease compared with controls (10 out of 30 versus six out of 61). The radiological features of Aspergillus-related lung disease were also more common among patients with NTM disease than controls (six out of 30 versus none out of 61). This association between NTM disease and Aspergillus-related lung disease remained significant after adjustment for confounding effects of age and lung function (adjusted odds ratio 5.1, 95% confidence interval 1.5-17.0).Patients with bronchiectasis and nontuberculous mycobacterial disease have a higher prevalence of coexisting Aspergillus-related lung disease than patients with bronchiectasis and without nontuberculous mycobacteria. Identification of Aspergillus-related lung disease is important as prognosis amongst undetected cases is invariably poor.

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Section: Discussioncontrasting

confidence: 64%

Nontuberculous mycobacterial disease and Aspergillus-related lung disease in bronchiectasis

Kunst

Wickremasinghe²,

Wells³

et al. 2006

Eur Respir J

125

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“…In some reports, the invasion by Aspergillus species is restricted to the tissues surrounding the bronchiectatic segments with granulomatous reaction [252][253][254]. Some of these cases are more likely to represent the semi-invasive form of CNA rather than IPA due to their chronic courses.…”

Section: Pulmonary Aspergillus Overlap Syndromesmentioning

confidence: 99%

Pulmonary aspergillosis: a clinical review

Kousha¹,

Tadi²,

Soubani³

2011

Eur Respir Rev

599

596

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Aspergillus is a mould which may lead to a variety of infectious, allergic diseases depending on the host's immune status or pulmonary structure. Invasive pulmonary aspergillosis occurs primarily in patients with severe immunodeficiency. The significance of this infection has dramatically increased with growing numbers of patients with impaired immune state associated with the management of malignancy, organ transplantation, autoimmune and inflammatory conditions; critically ill patients and those with chronic obstructive pulmonary disease appear to be at an increased risk. The introduction of new noninvasive tests, combined with more effective and better-tolerated antifungal agents, has resulted in lower mortality rates associated with this infection. Chronic necrotising aspergillosis is a locally invasive disease described in patients with chronic lung disease or mild immunodeficiency. Aspergilloma is usually found in patients with previously formed cavities in the lung, whereas allergic bronchopulmonary aspergillosis, a hypersensitivity reaction to Aspergillus antigens, is generally seen in patients with atopy, asthma or cystic fibrosis. This review provides an update on the evolving epidemiology and risk factors of the major manifestations of Aspergillus lung disease and the clinical manifestations that should prompt the clinician to consider these conditions. Current approaches for the diagnosis and management of these syndromes are discussed.

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“…The term invasive aspergillosis is often used in the context of aggressive disease in immunocompromised patients; however, this form of Aspergillus infection may be more indolent and occurs in patients with mycetoma or ABPA, and in patients with chronic debilitation [1,7,49]. By definition, the hyphae invade the adjacent lung parenchyma, first bronchial wall and subsequently the accompanying arterioles.…”

Section: Invasive Aspergillosismentioning

confidence: 99%

Aspergillus in the lung: diverse and coincident forms

Buckingham

Hansell

2003

Eur Radiol

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Pulmonary disease caused by the fungus Aspergillus has traditionally been regarded as belonging to one of the following, apparently distinct, entities: saprophytic aspergilloma; allergic bronchopulmonary aspergillosis (ABPA); and invasive aspergillosis (IPA); which may be further categorised as angioinvasive, acute or chronic airway invasive) [1]. It is not always obvious that there is overlap between these entities, and that in any given patient more than one Aspergillus-related pathological process can co-exist [2]. The aim of this article is to review the clinical and imaging features of the main categories of Aspergillus-related pulmonary disease and, in particular, to highlight the overlap between them.

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Invasive pulmonary aspergillosis complicating allergic bronchopulmonary aspergillosis

Cited by 34 publications

References 13 publications

Nontuberculous mycobacterial disease and Aspergillus-related lung disease in bronchiectasis

Nontuberculous mycobacterial disease and Aspergillus-related lung disease in bronchiectasis

Pulmonary aspergillosis: a clinical review

Aspergillus in the lung: diverse and coincident forms

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