Invasive rodent eradication on islands: assessment and mitigation of human exposure to rodenticides

Castaño, Paula A.; Hanson, Chad C.; Campbell, Karl J.; Carrión, Victor G.; Fisher, Penny; Ruell, Emily W.; Will, David; Siers, Shane R.

doi:10.1007/s10530-022-02940-1

Cited by 3 publications

(1 citation statement)

References 48 publications

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“…Brodifacoum has a drawback which makes it less attractive for island eradication efforts: it has a longer persistence in the environment than first-generation anticoagulants, such as diphacinone [4]. This difference in environmental half-life makes diphacinone more attractive for eradication efforts when large quantities will be applied in a short span of time, especially in ecologically sensitive areas or where there may be pathways to human exposure [5].…”

Section: Introductionmentioning

confidence: 99%

Determination of residue levels of rodenticide in rodent livers offered novel diphacinone baits by liquid chromatography-tandem mass spectrometry

et al. 2023

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A specific and sensitive liquid chromatography-tandem mass spectrometry method was developed and validated for the determination of the anticoagulant rodenticide diphacinone (DPN) in mouse and rat liver. Tissue samples were extracted with a mixture of water and acetonitrile containing ammonium hydroxide. The extracted sample was cleaned up with a combination of liquid-liquid partitioning and dispersive solid phase extraction. Chromatographic separation was achieved using a Waters X-Bridge BEH C-18 LC column (50 mm, 2.1 mm ID, 2.5 μm particle size) with detection on a triple quadrupole mass spectrometer in multiple reaction monitoring (MRM) mode. The monitored transition for DPN was m/z 339.0 → 167.0 for quantitation and 339.0 → 172.0 and 339.0 → 116.0 for confirmation. The linear range was 0.5 to 375 ng/mL. The average precision of DPN, represented by the relative standard deviation of the observed concentrations, was 7.2% (range = 0.97% - 20.4%) and the average accuracy, represented by the relative error, was 5.8% (range = 1.06% - 14.7%). The recovery of DPN fortified at 3 different levels averaged 106% in rat liver and 101% in mouse liver. The established method was successfully used to determine DPN residue levels in Polynesian rats (Rattus exulans) and mice (Mus musculus) fed two different formulated baits containing DPN. The observed residue levels were consistent with values observed in other rodent studies. However, the amount of bait consumed was lower for the novel baits evaluated in this study.

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Section: Introductionmentioning

confidence: 99%

Determination of residue levels of rodenticide in rodent livers offered novel diphacinone baits by liquid chromatography-tandem mass spectrometry

et al. 2023

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A Sustainable Rat Management Model in Rice Field by Natural Propagation of a Local Predator, the Barn Owl, Tyto javanica

Mohd Noor,

Na’im,

Burhanuddin

2024

Advances in Tropical Crop Protection

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Assessing the Conservation Status of Invasive Acomys cilicicus: Conservation Taxonomic Unit or Distinct Species?

Matur

Çetintaş

Çolak

et al. 2023

Preprint

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Acomys cilicicus is a rodent species endemic to Turkey, with a highly restricted distribution. However, there have been doubts regarding its taxonomic validity as a distinct species. Previous studies investigating the phylogeny of A. cilicicus have been unable to provide conclusive data to address this validity issue, primarily due to their reliance on two specimens from a single locality. In this study, we expanded the sample size to include 16 specimens from 5 different localities and conducted sequencing of a mitochondrial DNA gene region (cyt-b). Initial analysis of genetic distances revealed a close relationship between cilicicus, minous, and nesiotes. To further explore the phylogenetic relationships, we incorporated additional mtDNA sequences from GenBank into our analysis, resulting in the construction of a phylogenetic tree. Our findings demonstrate that cilicicus forms a distinct clade, supporting its status as a separate species. Moreover, the cilicicus clade was identified as the sister clade of A. minous. By estimating the divergence time, we determined that cilicicus diverged from its closest relative, minous, approximately 170 thousand years ago. Additionally, based on our sequence data, we propose a hypothesis suggesting that cilicicus might have been introduced to Anatolia from Crete during the Lower Palaeolithic era. We further discussed the inferred migration pathways of the Mediterranean region based on clade formation and migration analysis.

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Invasive rodent eradication on islands: assessment and mitigation of human exposure to rodenticides

Cited by 3 publications

References 48 publications

Determination of residue levels of rodenticide in rodent livers offered novel diphacinone baits by liquid chromatography-tandem mass spectrometry

Determination of residue levels of rodenticide in rodent livers offered novel diphacinone baits by liquid chromatography-tandem mass spectrometry

A Sustainable Rat Management Model in Rice Field by Natural Propagation of a Local Predator, the Barn Owl, Tyto javanica

Assessing the Conservation Status of Invasive Acomys cilicicus: Conservation Taxonomic Unit or Distinct Species?

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