1997
DOI: 10.1148/radiology.204.3.9280272
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Invasive thymoma: treatment with postoperative radiation therapy.

Abstract: With total doses of 45-50 Gy, local control is achievable after radical resection. Whether patients with completely resected stage II thymomas should receive radiation after surgery remains uncertain, as does the role of chemotherapy in the treatment of thymoma.

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Cited by 62 publications
(31 citation statements)
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“…There are various postoperative dose and fraction schemes reported in the literature [123], but generally 45-55 Gy are recommended [8,11,13,88,[124][125][126][127], even if there is no clear dose-response relationship because of the relatively small number of patients enrolled in the different studies and lack of prospective randomised trials. In patients with bulky disease, doses higher than 60 Gy have been proposed [127,128] since lower doses have been found to adversely affect prognosis [129].…”
Section: Radiotherapymentioning
confidence: 99%
“…There are various postoperative dose and fraction schemes reported in the literature [123], but generally 45-55 Gy are recommended [8,11,13,88,[124][125][126][127], even if there is no clear dose-response relationship because of the relatively small number of patients enrolled in the different studies and lack of prospective randomised trials. In patients with bulky disease, doses higher than 60 Gy have been proposed [127,128] since lower doses have been found to adversely affect prognosis [129].…”
Section: Radiotherapymentioning
confidence: 99%
“…The data showed that the surgical resection followed by postoperative irradiation could get good local control, but distant metastatic rate was still high. Postoperative irradiation was recommended for invasive thymoma (17,22,23,24,25). However, the role of irradiation in the treatment of thymic carcinoma was unclear because of limited experience.…”
Section: Overall Survival Ratementioning
confidence: 99%
“…In a retrospective series analyzed by Latz et al, 38 irradiation was given to 43 patients between 1981 and 1995 after total (n ϭ 23) or subtotal (n ϭ 20) resection. Tumors were thymic carcinoma (n ϭ 10) or invasive thymoma (n ϭ 33), 39 compared irradiation of the entire hemithorax plus mediastinum (Group 1) with mediastinal irradiation only (Group 2) in patients with Stage II or Stage III tumors.…”
Section: Radiation Therapymentioning
confidence: 99%