Invasive trichosporonosis in an AIDS patient: case report and review of the literature

Roman, Arthur Dessi; Salvaña, Edsel Maurice; Guzman-Peñamora, Mary Ann J De; Roxas, Evalyn A.; Leyritana, Katerina; Saniel, M. C.

doi:10.1177/0956462413487716

Cited by 11 publications

(4 citation statements)

References 24 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…White piedra presents as asymptomatic, soft, white or cream colored nodules that are loosely adherent to hair shafts. While this is primarily a self-limited infection, T. asahii has been known to cause a systemic infection called trichosporonosis in immunosuppressed patients [ 9 ]. This is a multisystem disease that includes fevers, renal failure, pulmonary infi ltrates, and skin lesions that range from papules to necrotic nodules.…”

Section: Nondermatophytes Piedramentioning

confidence: 99%

Infections in the Kidney Transplant Recipient

Russell

McCall

2015

Dermatological Manifestations of Kidney Disease

View full text Add to dashboard Cite

Section: Nondermatophytes Piedramentioning

confidence: 99%

Infections in the Kidney Transplant Recipient

Russell

McCall

2015

Dermatological Manifestations of Kidney Disease

View full text Add to dashboard Cite

“…Most cases of invasive infection are seen in patients with neutropenia and malignancy, especially in adults and children with hematological malignancies and intravascular indwelling catheters. Premature neonates with a low birth weight, patients with Acquired Immune Deficiency Syndrome (AIDS) and critically ill patients exposed to broad-spectrum antibiotics are also at increased risk [20][21][22][23][24][25][26][27]. Data regarding ITIs in children are based on case reports and small case series.…”

Section: Introductionmentioning

confidence: 99%

Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders

Kourti

Roilides

2022

Pathogens

View full text Add to dashboard Cite

(1) Background: Trichosporon species have emerged as important opportunistic fungal pathogens, with Trichosporon asahii being the leading and most frequent cause of invasive disease. (2) Methods: We performed a global review focused on invasive trichosporonosis in neonates and pediatric patients with malignancies or hematologic disorders. We reviewed case reports and case series of trichosporonosis due to T. asahii published since 1994, the year of the revised taxonomic classification. (3) Results: Twenty-four cases of invasive trichosporonosis were identified in neonates with the presence of central venous catheter and use of broad-spectrum antibiotics recognized as the main predisposing factors. Thirty-two cases were identified in children with malignancies or hematologic disorders, predominantly with severe neutropenia. Trichosporon asahii was isolated from blood in 24/32 (75%) pediatric cases. Cutaneous involvement was frequently observed in invasive trichosporonosis. Micafungin was the most commonly used prophylactic agent (9/22; 41%). Ten patients receiving prophylactic echinocandins were identified with breakthrough infections. A favorable outcome was reported in 12/16 (75%) pediatric patients receiving targeted monotherapy with voriconazole or combined with liposomal amphotericin B. Overall mortality in neonates and children with malignancy was 67% and 60%, respectively. (4) Conclusions: Voriconazole is advocated for the treatment of invasive trichosporonosis given the intrinsic resistance to echinocandins and poor susceptibility to polyenes.

show abstract

“…Most cases of invasive infection are seen in patients with neutropenia and malignancy and especially in adults and children with hematological malignancies and intravascular indwelling catheters. Premature neonates with low birth weight, patients with AIDS and critically ill patients exposed to broad-spectrum antibiotics are also at increased risk of it [20][21][22][23][24][25][26][27]. Most reports of ITIs in children are based on case reports and small case series.…”

Section: Introductionmentioning

confidence: 99%

Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders

Kourti¹,

Roilides²

2022

Preprint

View full text Add to dashboard Cite

(1) Background: Trichosporon species have emerged as important opportunistic fungal pathogens, with Trichosporon asahii being the leading and most frequent cause of invasive disease. (2) Methods: We performed a global review focused on invasive trichosporonosis in neonates and pediatric patients with malignancies or hematologic disorders. We reviewed case reports and case series of trichosporonosis due to T. asahii published since 1994, year of the revised taxonomic classification. (3) Results: Twenty-four cases of invasive trichosporonosis were identified in neonates with presence of central venous catheter and use of broad-spectrum antibiotics recognized as main predisposing factors. Thirty-two cases were identified in children with malignancies or hematologic disorders, predominantly with severe neutropenia. Trichosporon asahii was isolated from blood in 24/32 (75%) pediatric cases. Cutaneous involvement was frequently observed in invasive trichosporonosis. Micafungin was the most commonly used prophylactic agent (9/22; 41%). Ten patients receiving prophylactic echinocandins were identified with breakthrough infections. Favorable outcome was reported in 12/16 (75%) pediatric patients receiving targeted monotherapy with voriconazole or combined with liposomal amphotericin B. Overall mortality in neonates and children with malignancy was 67% and 60%, respectively. (4) Conclusions: Voriconazole is advocated for the treatment of invasive trichosporonosis given the intrinsic resistance to echinocandins and poor susceptibility to polyenes.

show abstract

Invasive trichosporonosis in an AIDS patient: case report and review of the literature

Cited by 11 publications

References 24 publications

Infections in the Kidney Transplant Recipient

Infections in the Kidney Transplant Recipient

Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders

Invasive Trichosporonosis in Neonates and Pediatric Patients with Malignancies or Hematologic Disorders

Contact Info

Product

Resources

About