2022
DOI: 10.1161/jaha.121.025205
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Invasive Versus Medical Management in Patients With Chronic Kidney Disease and Non–ST‐Segment–Elevation Myocardial Infarction

Abstract: Background The role of invasive management compared with medical management in patients with non–ST‐segment–elevation myocardial infarction (NSTEMI) and advanced chronic kidney disease (CKD) is uncertain, given the increased risk of procedural complications in patients with CKD. We aimed to compare clinical outcomes of invasive management with medical management in patients with NSTEMI‐CKD. Methods and Results We identified NSTEMI and CKD… Show more

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Cited by 6 publications
(12 citation statements)
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“…We conducted previously validated falsification end point and E-value analysis to evaluate the robustness of our findings. [12][13][14][15][16] In the falsification method, we selected an alternative outcome that may not be expected to be causally affected by the treatment being studied. Then, we assessed whether the study intervention (ER) was associated with alternative outcomes by using a similar method to assess other study outcomes.…”
Section: Unmeasured Bias Analysismentioning
confidence: 99%
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“…We conducted previously validated falsification end point and E-value analysis to evaluate the robustness of our findings. [12][13][14][15][16] In the falsification method, we selected an alternative outcome that may not be expected to be causally affected by the treatment being studied. Then, we assessed whether the study intervention (ER) was associated with alternative outcomes by using a similar method to assess other study outcomes.…”
Section: Unmeasured Bias Analysismentioning
confidence: 99%
“…Hospitals were divided into quartiles (first, second, third, and fourth quartile) to ensure an equal number of procedures. Hospitals in the fourth quartile were considered high-volume hospitals (median number of procedures, 52 [IQR, 43-73]), and those in the first to third quartiles were considered low-volume hospitals (median number of procedures, 16 [IQR,[9][10][11][12][13][14][15][16][17][18][19][20][21][22][23][24][25][26]).…”
mentioning
confidence: 99%
“…In this context, the study by Majmundar et al 15 in this issue of the Journal of the American Heart Association ( JAHA ) should be viewed. The authors conducted an observational analysis of the National Readmission Database (NRD) from years 2016 to 2018 comparing an invasive strategy versus none among patients with NSTEMI and stages 3 to 5 CKD or end‐stage renal disease.…”
mentioning
confidence: 99%
“…The authors conducted an observational analysis of the National Readmission Database (NRD) from years 2016 to 2018 comparing an invasive strategy versus none among patients with NSTEMI and stages 3 to 5 CKD or end‐stage renal disease. 15 Their analysis included 141 052 admissions, of which 60.9% admissions underwent an invasive strategy (coronary angiography with or without percutaneous coronary intervention or coronary artery bypass grafting). Patients who did not receive invasive management were older and more likely women.…”
mentioning
confidence: 99%
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