Invasive Vulval Paget’s disease treated with primary radiotherapy: A rare case report and literature review

Sarkar, Avir; Saha, S.; Sikka, Pooja; Kumari, Neha; Dey, Pranab; Rai, Bhavana

doi:10.1016/j.gore.2020.100674

Cited by 4 publications

(5 citation statements)

References 17 publications

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“…Nonetheless, many reports had short follow-ups, which were insufficient to determine the true effect of RT. 6-8 Our patient experienced a durable response to RT, with no evidence of disease at >6 years of follow-up. Furthermore, no serious late toxicities occurred.…”

Section: Discussionmentioning

confidence: 75%

“…Moreover, many reports lack longterm observations after treatment and therefore lack information about the true effects of definitive RT. [6][7][8] Herein, we present the case of an elderly patient with penoscrotal EMPD treated with definitive RT who attained longterm complete response without serious toxicity.…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, many reports lack long-term observations after treatment and therefore lack information about the true effects of definitive RT. 6-8…”

Section: Introductionmentioning

confidence: 99%

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Definitive Radiotherapy for Penoscrotal Extramammary Paget’s Disease: A Case Report with Long-Term Follow-Up

Suzuki

Machida

Asato

et al. 2021

Clin Med Insights Case Rep

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Penoscrotal extramammary Paget’s disease (EMPD) is a rare intraepithelial adenocarcinoma in older male patients, and no effective nonsurgical treatment strategies are currently available. The aim of this study was to report the usefulness of external radiotherapy (RT) for penoscrotal EMPD in an inoperable elderly patient. This report presents the treatment of an 89-year-old man with widespread penoscrotal EMPD. A multidisciplinary treatment team decided on radical RT. The patient received a radiation dose of 61.8 Gy in 30 fractions through electron and photon beams. His treatment tolerance was good, and no severe toxicity had been observed up the last follow-up. At 6.5 years after the RT, the patient showed no evidence of recurrence. Definitive RT resulted in excellent disease control and minimal toxicity; thus, it could be a promising nonsurgical therapeutic option for penoscrotal EMPD, even in extremely elderly individuals.

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Section: Discussionmentioning

confidence: 75%

Section: Introductionmentioning

confidence: 99%

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Definitive Radiotherapy for Penoscrotal Extramammary Paget’s Disease: A Case Report with Long-Term Follow-Up

Suzuki

Machida

Asato

et al. 2021

Clin Med Insights Case Rep

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“…[ 2 ] The authors reviewed the published Indian literature on EMPD and found that while many images showed the presence of pigmentary alterations (hypo-, de-, and hyperpigmentation), the same was not reflected in the case description in those reports. [ 2 3 4 5 6 7 8 9 10 11 12 13 14 ] Hence, we believe that pigmentary changes in EMPD may be under-reported in brown-skinned individuals, reflecting a lack of awareness about the same.…”

Section: Discussionmentioning

confidence: 97%

A Clinicopathological and Immunohistochemical Profile of Primary Extra Mammary Paget's Disease in Skin of Colour: A Case Series

Dhar,

Gupta,

Chakraborty

et al. 2023

Indian Journal of Dermatology

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Extramammary Paget's disease is an intraepithelial neoplasm, usually found in areas rich in apocrine gland concentration. The clinical features, histopathology, immunohistochemistry and management details of five patients (F = 3, M = 2) have been described here. While a well-defined persistent plaque with crusting and erosion was the most common presentation, hyperpigmentation, hypopigmentation and depigmentation were also observed in two patients. Characteristic Paget's cells with cytokeratin 7 and EMA positivity were seen on histopathology examination. Authors conclude that pigmentary alterations may be under-reported in extra mammary Paget's disease in the skin of colour.

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“…In this case, the patient was diagnosed with primary EMPD, with a large range of skin lesions, without lymph nodes and other internal organs metastasis, using local skin lesion enlargement excision, according to the size of the trauma to design the axillary near the back of the free skin ap, intraoperative re nement of the rapid frozen section examination showed negative margins, no lymph node metastasis, not only the incision is hidden, trauma is small, and it can be maximally maintain the appearance of the breasts and the function of the breasts are not affected, and signi cantly The quality of life of the patients was improved. However, the role of RT remains controversial, as only 15 patients have been treated with RT as the primary treatment modality to date [25,26]. Photodynamic therapy is the destruction of tumor cells by exogenous reactive oxygen species produced by light photosensitizers, the overall complete response rate was only 36%, making treatment in EMPD more limited [27].…”

Section: Discussionmentioning

confidence: 99%

Extramammary Paget’s disease of the unilateral axilla: a case report and literature review

Liu,

et al. 2023

Preprint

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Background: Extramammary paget disease (EMPD) is a rare neoplastic dermatosis that mainly affects areas with high parietal gland concentration, such as the vulva and groin, and is very rare in the axilla. Only a few cases have been reported internationally. It is the rarity of the disease that often leads to delayed diagnosis and delays in the condition. Accordingly, early diagnosis and treatment are very critical for prognosis. This report provides good clinical ideas for the diagnosis and treatment of EMPD. Case presentation: In this study, we described a case of unilateral axillary paget disease. A 52-year-old female patient presented with recurrent erythema, erosion and pruritus in the right armpit for more than 10 years. The patient was finally diagnosed with EMPD by pathological biopsy and immunohistochemical examination, and was cured after surgical treatment. She is currently under follow-up observation. Conclusions: EMPD of the axillary region is a rare fifinding even in a large medical center. This report provides good clinical ideas for the diagnosis and treatment of EMPD.

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Invasive Vulval Paget’s disease treated with primary radiotherapy: A rare case report and literature review

Cited by 4 publications

References 17 publications

Definitive Radiotherapy for Penoscrotal Extramammary Paget’s Disease: A Case Report with Long-Term Follow-Up

Definitive Radiotherapy for Penoscrotal Extramammary Paget’s Disease: A Case Report with Long-Term Follow-Up

A Clinicopathological and Immunohistochemical Profile of Primary Extra Mammary Paget's Disease in Skin of Colour: A Case Series

Extramammary Paget’s disease of the unilateral axilla: a case report and literature review

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